?url_ver=Z39.88-2004&rft_id=1517021100&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Adc&rft.title=UJI+EFEK+ANTI+HIPERGLIKEMIA+EKSTRAK+DAUN+SIRSAK+(Annona+muricata+L.)+TERHADAP+HISTOLOGI+HATI+MENCIT+(Mus+musculus+L.)+YANG+DIINDUKSI+GLUKOSA&rft.creator=Muammar+%2C+Ihsan+Hawari+&rft.subject=001+Ilmu+pengetahuan&rft.subject=570+Biologi&rft.description=Blood+glucose+levels+are+a+very+important+factor+for+the+smooth+work+of+the+body.+When+the+blood+glucose+level+in+the+body+is+too+high%2C+it+will+affect+the+liver+organs.+This+study+aims+to+find+out+whether+the+antihyperglycemic+content+of+soursop+leaves+(Annona+muricata+L.)+can+have+an+effect+on+reducing+hepatocyte+cell+necrosis+in+the+liver+organs+of+mice+(Mus+musculus)+due+to+high+blood+glucose+levels+from+the+influence+of+50%25+glucose+induction.+This+study+used+the+Complete+Randomized+Design+(CRD)+method.+20+male+mice+were+divided+into+5+treatment+groups+and+4+repetitions%2C+namely+the+treatment+(P1%2C+P2%2C+and+P3)+given+doses+of+soursop+leaf+extract+of+250%2C+500%2C+and+750mg%2Fkgbw%2C+as+well+as+the+control+group+(K-+and+K%2B)+which+were+given+CMC+0.5%25+and+glibenclamide+respectively.+The+data+obtained+from+this+study+were+taken+from+slices+of+mice+liver+preparations+observed+around+the+central+vein+under+a+microscope+with+a+magnification+of+40x%2C+then+analyzed+statistically+with+one-way+ANOVA+(Analysis+of+variance)+to+determine+the+difference+between+the+treatment+and+control+groups.+Data+collection+was+taken+after+14+days+since+the+mice+were+given+glucose+and+soursop+leaf+extract.+The+data+taken+showed+significant+differences+between+the+K%2B+(glibenclamide)+group+and+the+K-+group+(CMC+0.5%25)+and+the+P1+treatment+(250mg%2Fkgbw)+showed+not+very+significant+results+with+the+K%2B+(glibenclamide)+group%2C+but+had+significant+results+with+the+P2+(500mg%2Fkgbw)+and+P3+(750mg%2Fkgbw)+treatment+groups.+The+conclusion+of+this+study+is+that+the+concentration+of+soursop+leaf+extract+can+prevent+hepatocyte+cell+necrosis+in+the+liver+mice%2C+with+the+best+dose%2C+namely+in+the+P3+treatment+(750mg+%2F+kgbw).%0D%0AKeywords%3A+Hyperglycemia%2C+soursop+leaf+extract%2C+necrosis%2C+glucose%2C+mice%2C+Annona+muricata+L%2C+Mus+musculus+L.%0D%0A%0D%0AKadar+glukosa+darah+merupakan+faktor+yang+sangat+penting+untuk+kelancaran+kerja+tubuh.+Ketika+kadar+glukosa+darah+pada+tubuh+terlalu+tinggi+maka+akan+berpengaruh+terhadap+organ+hati.+Pada+penelitian+kali+ini+bertujuan+untuk+mengetahui+apakah+kandungan+antihiperglikemia+daun+sirsak+(Annona+muricata+L.)+dapat+berpengaruh+dalam+menurunkan+nekrosis+sel+hepatosit+pada+organ+hati+mencit+(Mus+musculus)+akibat+kadar+glukosa+darah+tinggi+dari+pengaruh+induksi+glukosa+50%25.+Penelitian+ini+menggunakan+metode+Rancangan+Acak+Lengkap+(RAL).+20+ekor+mencit+jantan+dibagi+atas+5+kelompok+perlakuan+dan+4+pengulangan%2C+yaitu+perlakuan+(P1%2C+P2%2C+dan+P3)+diberikan+dosis+ekstrak+daun+sirsak+sebanyak+250%2C+500%2C+dan+750mg%2FkgBB%2C+serta+kelompok+kontrol+(K-+dan+K%2B)+yang+masing-masing+diberikan+CMC+0%2C5%25+dan+glibenklamid+secara+oral.+Data+yang+didapatkan+dari+penelitian+ini+diambil+dari+irisan+preparat+hati+mencit+yang+diamati+disekitar+vena+sentralis+dibawah+mikroskop+dengan+perbesaran+40x%2C+lalu+dianalisis+secara+statistik+dengan+one+way+ANOVA+(Analisis+of+variance)+untuk+mengetahui+adanya+perbedaan+antara+kelompok+perlakuan+dan+kontrol.+Pengambilan+data+diambil+setelah+14+hari+semenjak+mencit+diberikan+glukosa+dan+ekstrak+daun+sirsak.+Data+yang+diambil+menunjukkan+perbedaan+yang+signifikan+antara+kelompok+K%2B+(glibenklamid)+dengan+kelompok+K-+(CMC+0%2C5%25)+serta+pada+perlakuan+P1+(250mg%2FkgBB)+menunjukkan+hasil+yang+tidak+terlalu+signifikan+dengan+kelompok+K%2B(glibenklamid)%2C+namun+memiliki+hasil+yang+signifikan+dengan+kelompok+perlakuan+P2+(500mg%2FkgBB)+dan+P3+(750mg%2FkgBB).+Simpulan+dari+penelitian+ini+yaitu+konsentrasi+ekstrak+daun+sirsak+dapat+mencegah+terjadinya+nekrosis+sel+hepatosit+pada+hati+mencit%2C+dengan+dosis+yang+paling+baik+yaitu+pada+perlakuan+P3+(750mg%2FkgBB).%0D%0AKata+kunci%3A+Hiperglikemia%2C+ekstrak+daun+sirsak%2C+nekrosis%2C+glukosa%2C+mencit%2C+Annona+muricata+L%2C+Mus+musculus+L.&rft.publisher=FAKULTAS+MATEMATIKA+DAN+ILMU+PENGETAHUAN+ALAM&rft.date=2022-08-04&rft.type=Skripsi&rft.type=NonPeerReviewed&rft.format=text&rft.identifier=http%3A%2F%2Fdigilib.unila.ac.id%2F71610%2F1%2FABSTRAK.pdf&rft.format=text&rft.identifier=http%3A%2F%2Fdigilib.unila.ac.id%2F71610%2F2%2FSKRIPSI%2520FULL.pdf&rft.format=text&rft.identifier=http%3A%2F%2Fdigilib.unila.ac.id%2F71610%2F3%2FSKRIPSI%2520TANPA%2520BAB%2520PEMBAHASAN.pdf&rft.identifier=++Muammar+%2C+Ihsan+Hawari+++(2022)+UJI+EFEK+ANTI+HIPERGLIKEMIA+EKSTRAK+DAUN+SIRSAK+(Annona+muricata+L.)+TERHADAP+HISTOLOGI+HATI+MENCIT+(Mus+musculus+L.)+YANG+DIINDUKSI+GLUKOSA.++FAKULTAS+MATEMATIKA+DAN+ILMU+PENGETAHUAN+ALAM%2C+UNIVERSITAS+LAMPUNG.+++++&rft.relation=http%3A%2F%2Fdigilib.unila.ac.id%2F71610%2F