?url_ver=Z39.88-2004&rft_id=1917011027&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Adc&rft.title=UJI+AKTIVITAS+ANTIDIABETES+TURUNAN+SENYAWA+TANIN+DARI%0D%0AEKSTRAK+KULIT+BATANG+KELOR+(Moringa+oleifera)+SECARA+%0D%0AIN+SILICO+TERHADAP+PROTEIN+3KC0+DAN+IN+VIVO%0D%0ATERHADAP+MENCIT+(Mus+musculus)&rft.creator=FITRI+%2C+FEBRIANI&rft.subject=500+ilmu+pengetahuan+alam+dan+matematika&rft.subject=540+Kimia+dan+ilmu+yang+berhubungan&rft.description=Kandungan+senyawa+tanin+diketahui+dapat+menurunkan+kadar+glukosa+darah.%0D%0APenelitian+ini+dilakukan+untuk+mengetahui+jenis+turunan+senyawa+tanin+yang%0D%0Aberpotensi+sebagai+kandidat+obat+antidiabetes+serta+mengetahui+pengaruh%0D%0Apemberian+ekstrak+kulit+batang+kelor+terhadap+penurunan+kadar+glukosa+darah.%0D%0AProsedur+yang+dilakukan+yaitu+menganalisis+senyawa+tanin+ekstrak+kulit+batang%0D%0Akelor%2C+memprediksi+sifat+farmakokinetik%2C+toksisitas%2C+serta+molecular+docking%0D%0Aturunan+senyawa+tanin+terhadap+protein+3KC0%2C+dan+menentukan+dosis+ekstrak+kulit%0D%0Abatang+kelor+terbaik+dalam+menurunkan+kadar+glukosa+darah.+Berdasarkan+hasil%0D%0Askrining+fitokimia%2C+UV-Vis%2C+dan+FTIR%2C+ekstrak+kulit+batang+kelor+positif%0D%0Amengandung+tanin+jenis+katekin.+Hasil+uji+in+silico+menunjukkan+senyawa+katekin%0D%0Amemiliki+sifat+farmakokinetik+dan+toksisitas+terbaik+dan+paling+aman+digunakan.%0D%0AHasil+molecular+docking+menyatakan+senyawa+katekin+memiliki+nilai+RMSD+0%2C11%0D%0A%C3%85+dengan+energi+ikatan+-9%2C14+kkal%2Fmol.+Hasil+uji+in+vivo+menunjukkan+dosis+200%0D%0Amg%2Fkg+BB+adalah+dosis+yang+paling+efektif+menurunkan+glukosa+darah+mencit%0D%0Adengan+%25GL+sebesar+69%2C39%25.+Berdasarkan+hasil+penelitian+dapat+disimpulkan%0D%0Asenyawa+tanin+yang+terkandung+dalam+ekstrak+kulit+batang+kelor+dapat+dijadikan%0D%0Asebagai+kandidat+obat+diabetes+melitus.%0D%0A+%0D%0AKata+kunci%3A+antidiabetes%2C+kulit+batang+kelor%2C+tanin%2C+molecular+docking%2C+mencit.%0D%0A%0D%0A%0D%0A%0D%0A%0D%0A%0D%0A%0D%0Aabstract%0D%0A%0D%0AThe+content+of+tannin+compounds+is+known+to+lower+blood+glucose+levels.+This%0D%0Aresearch+was+conducted+to+determine+the+types+of+tannin+derivatives+that+have+the%0D%0Apotential+as+antidiabetic+drug+candidates+and+to+determine+the+effect+of+moringa%0D%0Astem+bark+extract+on+reducing+blood+glucose+levels.+The+procedure+carried+out+was%0D%0Ato+analyze+the+tannin+compounds+of+moringa+bark+extract%2C+predict+pharmacokinetic%0D%0Aproperties%2C+toxicity%2C+and+molecular+docking+of+tannin+derivatives+against+3KC0%0D%0Aprotein%2C+and+determine+the+best+dose+of+moringa+bark+extract+in+lowering+blood%0D%0Aglucose+levels.+Based+on+the+results+of+phytochemical%2C+UV-Vis%2C+and+FTIR%2C+the%0D%0Amoringa+stem+bark+extract+positively+contained+catechin+type+condensed+tannins.%0D%0AThe+in+silico+test+results+showed+that+catechin+compounds+had+the+best%0D%0Apharmacokinetic+and+toxicity+properties+and+were+the+safest+to+use.+Molecular%0D%0Adocking+results+show+that+the+catechin+compound+has+an+RMSD+value+of+0.11+%C3%85%0D%0Awith+a+bond+energy+of+-9.14+kcal%2Fmol.+The+in+vivo+test+results+showed+that+a+dose%0D%0Aof+200+mg%2Fkg+BW+was+the+most+effective+dose+in+lowering+the+blood+glucose+of%0D%0Amice+with+a+%25GL+of+69.39%25.+Based+on+the+results+of+the+study%2C+it+can+be%0D%0Aconcluded+that+the+tannin+compounds+contained+in+moringa+stem+bark+extract+can%0D%0Abe+used+as+candidates+for+diabetes+mellitus+drugs.%0D%0A+%0D%0AKeywords%3A+antidiabetic%2C+moringa+stem+bark%2C+tannins%2C+molecular+docking%2C+mice.+&rft.publisher=FAKULTAS+MATEMATIKA+DAN+ILMU+PENGETAHUAN+ALAM+&rft.date=2023-05-25&rft.type=Skripsi&rft.type=NonPeerReviewed&rft.format=text&rft.identifier=http%3A%2F%2Fdigilib.unila.ac.id%2F72117%2F1%2FABSTRAK.pdf&rft.format=text&rft.identifier=http%3A%2F%2Fdigilib.unila.ac.id%2F72117%2F3%2FSKRIPSI%2520FULL.pdf&rft.format=text&rft.identifier=http%3A%2F%2Fdigilib.unila.ac.id%2F72117%2F2%2FSKRIPSI%2520TANPA%2520BAB%2520PEMBAHASAN.pdf&rft.identifier=++FITRI+%2C+FEBRIANI++(2023)+UJI+AKTIVITAS+ANTIDIABETES+TURUNAN+SENYAWA+TANIN+DARI+EKSTRAK+KULIT+BATANG+KELOR+(Moringa+oleifera)+SECARA+IN+SILICO+TERHADAP+PROTEIN+3KC0+DAN+IN+VIVO+TERHADAP+MENCIT+(Mus+musculus).++FAKULTAS+MATEMATIKA+DAN+ILMU+PENGETAHUAN+ALAM+%2C+UNIVERSITAS+LAMPUNG.+++++&rft.relation=http%3A%2F%2Fdigilib.unila.ac.id%2F72117%2F