?url_ver=Z39.88-2004&rft_id=1957011013&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Adc&rft.title=UJI+IN+SILICO+SENYAWA+TURUNAN+TANIN+DENGAN+PROTEIN+1GFY+DAN+UJI+IN+VIVO+EKSTRAK+KULIT+BATANG+SUNGKAI+(Peronema+canescens+Jack)+PADA+MENCIT+(Mus+musculus+L.)+SEBAGAI+ANTIDIABETES++&rft.creator=+UNGGUL%2C++SULISTIO+SATRIO+UTOMO+&rft.subject=500+ilmu+pengetahuan+alam+dan+matematika&rft.subject=540+Kimia+dan+ilmu+yang+berhubungan&rft.description=Diabetes++Melitus++termasuk++penyakit%2Fgangguan++metabolisme++kronis++yang++ditandai+dengan+tingginya+kadar+glukosa+dalam+darah+oleh+kurangnya+respon+sel-sel+tubuh+terhadap++insulin.++++Ekstrak++metanol++kulit++batang++sungkai++terdeteksi++mengandung+senyawa+fenolik%2C+flavonoid%2C+dan+tanin.++Penelitian+ini+dilakukan+untuk+mengetahui+kandungan++senyawa++tanin++pada++ekstrak++kulit++batang++sungkai++yang++akan++diujikan+aktivitas++antidiabetesnya++secara++in++vivo++dan++in++silico.++++Prosedur++penelitian++yang+dilakukan++yaitu++mengekstraksi%2C++mengkarakterisasi%2C++dan++menguji++kandungan+senyawa++tanin++pada++EKBS%2C++menguji++keadaan++farmakokinetik++dan++molekular+docking+senyawa+turunan+tanin%2C+serta+menguji+ekstrak+pada+mencit+diabetes+untuk+mengetahui+penurunan+kadar+glukosa+darahnya.++Ekstrak+yang+diperoleh+sebesar+58+gram+dan+teruji+positif+mengandung+senyawa+tanin.++Hasil+karakterisasi+ekstrak+kulit+batang+sungkai+dengan+spektrofotometri+Uv-Vis+dan+IR+diperkirakan+mengandung+senyawa+turunan+tanin+yaitu+katekin.++Hasil+uji+farmakokinetik+dan+in+silico+dengan+protein+1GFY+menunjukkan+senyawa+katekin+merupakan+senyawa+terbaik+dengan+terbentuknya++energi++ikatan++dan++nilai++RMSD++yang++rendah%2C++terbentuknya++4++ikatan+hidrogen++dan++6++residu++asam++amino.++++Hasil++uji++antidiabetes++secara++in++vivo++EKBS+menyatakan++dosis++ke-3++(400++mg%2FkgBB)++adalah++dosis++yang++paling++efektif++dengan+nilai++%25++GL++sebesar++69%2C94%25.++++Berdasarkan++hal++tersebut++senyawa++tanin++yang+terkandung+dalam+ekstrak+kulit+batang+sungkai+diprediksi+dapat+dijadikan+sebagai+agen+obat+antidiabetes.+%0D%0AKata+Kunci%3A+Diabetes+Melitus%2C+Kulit+Batang+Sungkai%2C+Tanin%2C+mencit%2C+docking%2C+%0D%0A%0D%0ADiabetes++Mellitus++is++a++chronic++metabolic++disease%2Fdisorder++characterized++by++high+levels+of+glucose+in+the+blood+caused+by+a+lack+of+response+of+the+body's+cells+to+insulin.++Sungkai++stem++bark++methanol++extract++was++detected++to++contain++phenolic+compounds%2C+flavonoids%2C+and+tannins.+This+research+was+conducted+to+determine+the+content+of+tannin+compounds+in+sungkai+stem+bark+extract+which+would+be+tested+for+its+antidiabetic+activity+in+vivo+and+in+silico.+The+research+procedures+carried+out+were++extracting%2C++characterizing%2C++and++testing++the++content++of++tannin++compounds++in+extract%2C++testing++the++pharmacokinetics++and++molecular++docking++of++tannin-derived+compounds%2C+and+testing+the+extract+in+diabetic+mice+to+determine+a+decrease+in+their+blood++glucose++levels.++The++extract++obtained++was++58++grams++and++tested++positive++for+tannin+compounds.+The+results+of+the+characterization+of+Sungkai+stem+bark+extract+by++Uv-Vis++and++IR++spectrophotometry++are++estimated++to++contain++tannin++derivative+compounds%2C++namely++catechins.++The++results++of++pharmacokinetic++and++in++silico++tests+with++1GFY++protein++showed++that++catechins++were++the++best++compounds++with++the+formation++of++bond++energy++and++low++RMSD++values%2C++the++formation++of++4++hydrogen+bonds+and+6+amino+acid+residues.+The+results+of+the+anti-diabetic+test++in+vivo+extract+stated+that+the+3rd+dose+(400+mg%2Fkg+BW)+was+the+most+effective+dose+with+a+%25+GL+value+of+69.94%25.+Based+on+this%2C+the+tannin+compounds+contained+in+sungkai+stem+bark+extract+are+predicted+to+be+used+as+antidiabetic+drug+agents.%0D%0AKeywords%3A+diabetes+mellitus%2C+bark+sungkai%2C+tannins%2C+mice%2C+docking+++&rft.publisher=FAKULTAS+MATEMATIKA+DAN+ILMU+PENGETAHUAN+ALAM+&rft.date=2023-05-24&rft.type=Skripsi&rft.type=NonPeerReviewed&rft.format=text&rft.identifier=http%3A%2F%2Fdigilib.unila.ac.id%2F72122%2F1%2FABSTRAK.pdf&rft.format=text&rft.identifier=http%3A%2F%2Fdigilib.unila.ac.id%2F72122%2F2%2FSKRIPSI%2520FULL.pdf&rft.format=text&rft.identifier=http%3A%2F%2Fdigilib.unila.ac.id%2F72122%2F3%2FSKRIPSI%2520TANPA%2520BAB%2520PEMBAHASAN.pdf&rft.identifier=+++UNGGUL%2C+SULISTIO+SATRIO+UTOMO+++(2023)+UJI+IN+SILICO+SENYAWA+TURUNAN+TANIN+DENGAN+PROTEIN+1GFY+DAN+UJI+IN+VIVO+EKSTRAK+KULIT+BATANG+SUNGKAI+(Peronema+canescens+Jack)+PADA+MENCIT+(Mus+musculus+L.)+SEBAGAI+ANTIDIABETES.++FAKULTAS+MATEMATIKA+DAN+ILMU+PENGETAHUAN+ALAM+%2C+UNIVERSITAS+LAMPUNG.+++++&rft.relation=http%3A%2F%2Fdigilib.unila.ac.id%2F72122%2F