?url_ver=Z39.88-2004&rft_id=1917011050&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Adc&rft.title=BIOAKTIVITAS+EKSTRAK+ETIL+ASETAT+DARI+ACTINOMYCETE%0D%0ALUMPUR+MANGROVE+SEBAGAI+SENYAWA+ANTIBAKTERI%0D%0ATERHADAP+Pseudomonas+aeruginosa&rft.creator=REZA+%2C+FADHILA+&rft.subject=500+ilmu+pengetahuan+alam+dan+matematika&rft.subject=540+Kimia+dan+ilmu+yang+berhubungan&rft.description=%0D%0AKrisis+resistensi+bakteri+patogen+terhadap+antibiotik+menjadi+permasalahan%0D%0Autama+yang+dapat+menyebabkan+kematian.+Salah+satu+solusi+yang+bisa+dilakukan%0D%0Auntuk+mengatasi+resistensi+ini+ialah+menghadirkan+alternatif+senyawa+yang%0D%0Aberpotensi+sebagai+antibiotik+baru+melalui+isolasi+dari+sumber+alam+yang+lebih%0D%0Apotensial.+Penelitian+ini+bertujuan+untuk+mengetahui+bioaktivitas+antibakteri%0D%0Aekstrak+etil+asetat+Actinomycete+yang+berasal+dari+lumpur+mangrove.+Actinomycete%0D%0Adiisolasi+menggunakan+media+koloid+kitin+agar+1%25.+Isolat+dikultur+pada+media%0D%0Apadat+kulit+udang+dalam+kondisi+statis+selama+14+hari.+Bioaktivitas+antibakteri+diuji%0D%0Adengan+metode+mikrodilusi.+Isolat+unggul+diamati+morfologinya+menggunakan%0D%0Amikroskop+Al-Zeiss+dan+SEM.+Isolat+unggul+dikultur+pada+tiga+media+(kulit+udang%2C%0D%0Aberas%2C+dan+ISP2)+dan+kembali+diuji+bioaktivitas+antibakterinya+menggunakan%0D%0Ametode+difusi+agar.+Ekstrak+dan+fraksi+aktif+dikarakterisasi+menggunakan+FTIR.%0D%0ASebanyak+14+isolat+berhasil+diisolasi.+Berdasarkan+hasil+pengamatan+morfologi%2C%0D%0Aisolat+22-PMP3-A5+berasal+dari+genus+Actinoplane.+Hasil+uji+KLT+pada+kultur+tiga%0D%0Amedia+mengindikasikan+adanya+komponen+alkaloid+pada+Rf+0%2C7+dan+bottom+spot%0D%0Adalam+kultur+kulit+udang%2C+Rf+0%2C40+dan+0%2C90+dalam+kultur+beras%2C+kemudian+Rf+pada%0D%0Abottom+spot+dalam+kultur+ISP2.+Daya+inhibisi+terbesar+diperoleh+dari+kultur+media%0D%0Akulit+udang+dengan+kategori+inhibisi+kuat+sebesar+12+mm.+Fraksi+aktif+tersebut%0D%0Adiidentifikasi+sebagai+senyawa+alkaloid+yang+bersifat+non+UV+aktif+dan+berikatan%0D%0Adengan+asam+amino+pada+Rf+0%2C7.+Dengan+demikian%2C+hasil+penelitian+menunjukkan%0D%0Abahwa+Actinomycete+lumpur+mangrove+Pesawaran+isolat+22-PMP3-A5+berpotensi%0D%0Asebagai+sumber+bioaktivitas+antibakteri+dengan+daya+hambat+sebesar+70%2C99+%25%0D%0Aterhadap+bakteri+P.+aeruginosa+pada+dosis+450+%CE%BCg%2FmL.+Adanya+informasi+ini%0D%0Adiharapkan+dapat+digunakan+untuk+pengembangan+lebih+lanjut+dalam+memperoleh%0D%0Asenyawa+antibakteri.%0D%0AKata+Kunci%3A+Actinomycete%2C+bioaktivitas+antibakteri%2C+Actinoplane%2C+variasi+media%2C%0D%0AFTIR%0D%0A%0D%0AThe+crisis+of+resistance+of+pathogenic+bacteria+to+antibiotics+is+a+major+problem+that%0D%0Acan+cause+death.+One+solution+that+can+be+done+to+overcome+this+resistance+is+to%0D%0Apresent+alternative+compounds+that+have+the+potential+as+new+antibiotics+through%0D%0Aisolation+from+more+potential+natural+sources.+This+study+aims+to+determine+the%0D%0Aantibacterial+bioactivity+of+Actinomycete+ethyl+acetate+extract+from+mangrove+mud.%0D%0AActinomycete+was+isolated+using+colloidal+chitin+agar+1%25.+The+isolates+were%0D%0Acultured+on+solid+shrimp+shell+media+under+static+conditions+for+14+days.%0D%0AAntibacterial+bioactivity+was+tested+by+microdilution+method.+Superior+isolates%0D%0Aobserved+their+morphology+using+Al-Zeiss+and+SEM+microscopes.+The+superior%0D%0Aisolates+were+cultured+on+three+media+(shrimp+shells%2C+rice%2C+and+ISP2)+and+tested%0D%0Aagain+for+their+antibacterial+bioactivity+using+the+agar+diffusion+method.+Active%0D%0Aextracts+and+fractions+were+characterized+using+FTIR.+14+isolates+were+successfully%0D%0Aisolated.+Based+on+the+results+of+morphological+observations%2C+isolate+22-PMP3-A5%0D%0Acame+from+the+Actinoplane+genus.+TLC+test+results+on+the+culture+of+the+three+media%0D%0Ashowed+the+presence+of+alkaloid+components+at+Rf+0.7+and+bottom+spot+in+shrimp%0D%0Ashell+culture%2C+Rf+0.40+and+0.90+in+rice+culture%2C+then+Rf+in+the+bottom+spot+in+ISP2%0D%0Aculture.+The+greatest+inhibition+power+was+obtained+from+shrimp+shell+culture+media%0D%0Awith+a+strong+inhibition+category+of+12+mm.+The+active+fraction+was+identified+as+an%0D%0Aalkaloid+compound+which+is+non-UV+active+and+binds+to+amino+acids+at+Rf+0.7.%0D%0AThus%2C+the+results+showed+that+Actinomycete+mangrove+mud+Pesawaran+isolate+22-%0D%0APMP3-A5+has+the+potential+as+a+source+of+antibacterial+bioactivity+with+an+inhibition%0D%0Aof+70.99%25+against+P.+aeruginosa+bacteria+at+a+dose+of+450+%CE%BCg%2FmL.+It+is+hoped+that%0D%0Athis+information+can+be+used+for+further+development+in+obtaining+antibacterial%0D%0Acompounds.%0D%0AKeywords%3A+Actinomycete%2C+antibacterial+bioactivity%2C+Actinoplane%2C+various+media%2C%0D%0AFTIR&rft.publisher=FAKULTAS+MATEMATIKA+DAN+ILMU+PENGETAHUAN+ALAM&rft.date=2023-05-24&rft.type=Skripsi&rft.type=NonPeerReviewed&rft.format=text&rft.identifier=http%3A%2F%2Fdigilib.unila.ac.id%2F72363%2F1%2FABSTRAK.pdf&rft.format=text&rft.identifier=http%3A%2F%2Fdigilib.unila.ac.id%2F72363%2F3%2FSKRIPSI%2520FULL.pdf&rft.format=text&rft.identifier=http%3A%2F%2Fdigilib.unila.ac.id%2F72363%2F2%2FSKRIPSI%2520TANPA%2520BAB%2520PEMBAHASAN.pdf&rft.identifier=++REZA+%2C+FADHILA+++(2023)+BIOAKTIVITAS+EKSTRAK+ETIL+ASETAT+DARI+ACTINOMYCETE+LUMPUR+MANGROVE+SEBAGAI+SENYAWA+ANTIBAKTERI+TERHADAP+Pseudomonas+aeruginosa.++FAKULTAS+MATEMATIKA+DAN+ILMU+PENGETAHUAN+ALAM%2C+UNIVERSITAS+LAMPUNG.+++++&rft.relation=http%3A%2F%2Fdigilib.unila.ac.id%2F72363%2F