?url_ver=Z39.88-2004&rft_id=1917011030&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Adc&rft.title=MOLECULAR+DOCKING+SENYAWA+TURUNAN+FLAVONOID+DENGAN%0D%0APROTEIN+3KC0+DAN+UJI+AKTIVITAS+ANTIDIABETES+EKSTRAK%0D%0ADAUN+KELOR+PADA+MENCIT+JANTAN+(Mus+musculus)&rft.creator=Maysya+%2C+Dhiya+Rizky+Allisandra+&rft.subject=500+ilmu+pengetahuan+alam+dan+matematika&rft.subject=540+Kimia+dan+ilmu+yang+berhubungan&rft.description=%0D%0ADaun+kelor+dapat+dimanfaatkan+sebagai+antidiabetes+karena+adanya+kandungan%0D%0Asenyawa+flavonoid.+Penelitian+ini+bertujuan+untuk+mengetahui+jenis+senyawa%0D%0Aturunan+flavonoid+daun+kelor+sebagai+antidiabetes+berdasarkan+molecular+docking%0D%0Adan+mengetahui+aktivitas+antidiabetes+ekstrak+daun+kelor+pada+mencit+jantan.+Pada%0D%0Apenelitian+ini+dilakukan+ekstraksi+daun+kelor%2C+karakterisasi+senyawa+flavonoid%0D%0Adengan+spektrofotometer+UV-Vis%2C+spektrofotometer+FTIR+dan+LC-MS%2C+molecular%0D%0Adocking+senyawa+turunan+flavonoid+daun+kelor+dengan+protein+3KC0%2C+serta+uji%0D%0Aaktivitas+antidiabetes+ekstrak+daun+kelor+terhadap+mencit+jantan.+Hasil%0D%0Akarakterisasi+menunjukkan+ekstrak+daun+kelor+mengandung+senyawa+turunan%0D%0Aflavonoid+yaitu+myricetin%2C+hesperidin+dan+kuersetin.+Berdasarkan+molecular%0D%0Adocking%2C+senyawa+yang+berpotensi+sebagai+antidiabetes+adalah+senyawa+hesperidin%0D%0Adengan+energi+ikatan+sebesar+-10%2C03+kkal%2Fmol+dan+residu+asam+amino+pada+sisi%0D%0Aaktif+protein+3KC0+yaitu+LEU30%2C+THR27%2C+LYS112+dan+GLY28.+Senyawa+terbaik%0D%0Aberdasarkan+farmakokinetik+adalah+senyawa+kuersetin%2C+sedangkan+senyawa%0D%0Aterbaik+berdasarkan+hasil+toksisitas+adalah+senyawa+hesperidin.+Uji+aktivitas%0D%0Aantidiabetes+menunjukkan+dosis+optimal+ekstrak+daun+kelor+dalam+menurunkan%0D%0Akadar+glukosa+darah+mencit+jantan+yaitu+200+mg%2Fkg+BB+dan+persentase+penurunan%0D%0Aglukosa+(%25GL)+sebesar+69%2C56%25+dengan+nilai+signifikan+uji+ANOVA+p(%E2%89%A40%2C05).%0D%0AOleh+karena+itu%2C+daun+kelor+dapat+digunakan+sebagai+antidiabetes.%0D%0AKata+kunci%3A+antidiabetes%2C+daun+kelor%2C+flavonoid%2C+molecular+docking%2C+mencit.%0D%0A%0D%0AMoringa+leaves+can+be+used+as+an+antidiabetic+because+of+the+content+of+flavonoid%0D%0Acompounds.+This+study+aims+to+determine+the+types+of+flavonoid+derivative%0D%0Acompounds+of+Moringa+leaves+as+antidiabetics+based+on+molecular+docking+and%0D%0Adetermine+the+antidiabetic+activity+of+Moringa+leaves+extract+in+male+mice.+In+this%0D%0Astudy%2C+Moringa+leaves+extraction%2C+characterization+of+flavonoid+compounds+with%0D%0AUV-Vis+spectrophotometer%2C+FTIR+spectrophotometer+and+LC-MS%2C+molecular%0D%0Adocking+of+Moringa+leaves+flavonoid+derivative+compounds+with+3KC0+protein%2C%0D%0Aand+antidiabetic+activity+test+of+Moringa+leaves+extract+against+male+mice.+The%0D%0Acharacterization+results+show+that+Moringa+leaves+extract+contains+flavonoid%0D%0Aderivative+compounds%2C+namely+myricetin%2C+hesperidin+and+quercetin.+Based+on%0D%0Amolecular+docking%2C+compounds+that+have+potential+as+antidiabetics+are+hesperidin%0D%0Acompounds+with+binding+energy+of+-10.03+kcal+%2F+mol+and+amino+acid+residues+on%0D%0Athe+active+side+of+3KC0+proteins%2C+namely+LEU30%2C+THR27%2C+LYS112+and+GLY28.%0D%0AThe+best+compound+based+on+pharmacokinetics+is+quercetin+compound%2C+while+the%0D%0Abest+compound+based+on+toxicity+results+is+hesperidine+compound.+Antidiabetic%0D%0Aactivity+test+showed+the+optimal+dose+of+Moringa+leaves+extract+in+reducing+blood%0D%0Aglucose+levels+of+male+mice+was+200+mg%2Fkg+body+weight+and+the+percentage+of%0D%0Aglucose+reduction+(%25GL)+of+69.56%25+with+a+significant+value+of+ANOVA+test%0D%0A(p%E2%89%A40.05).+Therefore%2C+Moringa+leaves+can+be+used+as+an+antidiabetic.%0D%0AKeywords%3A+antidiabetic%2C+moringa+leaves%2C+flavonoids%2C+molecular+docking%2C+mice.&rft.publisher=FAKULTAS+MATEMATIKA+DAN+ILMU+PENGETAHUAN+ALAM&rft.date=2023-05-23&rft.type=Skripsi&rft.type=NonPeerReviewed&rft.format=text&rft.identifier=http%3A%2F%2Fdigilib.unila.ac.id%2F72374%2F1%2FABSTRAK.pdf&rft.format=text&rft.identifier=http%3A%2F%2Fdigilib.unila.ac.id%2F72374%2F2%2FSKRIPSI%2520FULL.pdf&rft.format=text&rft.identifier=http%3A%2F%2Fdigilib.unila.ac.id%2F72374%2F3%2FSKRIPSI%2520TANPA%2520BAB%2520PEMBAHASAN.pdf&rft.identifier=++Maysya+%2C+Dhiya+Rizky+Allisandra+++(2023)+MOLECULAR+DOCKING+SENYAWA+TURUNAN+FLAVONOID+DENGAN+PROTEIN+3KC0+DAN+UJI+AKTIVITAS+ANTIDIABETES+EKSTRAK+DAUN+KELOR+PADA+MENCIT+JANTAN+(Mus+musculus).++FAKULTAS+MATEMATIKA+DAN+ILMU+PENGETAHUAN+ALAM%2C+UNIVERSITAS+LAMPUNG.+++++&rft.relation=http%3A%2F%2Fdigilib.unila.ac.id%2F72374%2F