?url_ver=Z39.88-2004&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Adc&rft.title=INVESTIGASI+SENYAWA+BIOAKTIF+YANG+DIHASILKAN+OLEH+%0D%0AAKTINOMISETES+ENDOFIT+MANGROVE+SEBAGAI+ANTIBAKTERI+%0D%0ATERHADAP+BAKTERI+PATOGEN+RESISTEN%0D%0A&rft.creator=Fatur%2C+Rohim&rft.subject=500+ilmu+pengetahuan+alam+dan+matematika&rft.subject=540+Kimia+dan+ilmu+yang+berhubungan&rft.description=Aktinomisetes+endofit+mangrove+(AEM)+diketahui+memiliki+potensi+dalam+%0D%0Amemproduksi+senyawa+bioaktif+antibakteri.+Penelitian+ini+bertujuan+untuk%0D%0Amengidentifikasi+senyawa+bioaktif+yang+dihasilkan+oleh+AEM.+Aktinomisetes+%0D%0Adiperoleh+dari+tumbuhan+Mangrove+di+Hutan+Mangrove+Petengoran%2C+Pesawaran%2C+%0D%0ALampung.+Sampling+tumbuhan+mangrove+dilakukan+dengan+metode+acak+dan+%0D%0Apengayaan+aktinomisetes+dilakukan+dengan+metode+sterilisasi+permukaan+dan+%0D%0Acawan+sebar+pada+media+agar+koloid+kitin+1%25+dalam+air+laut.+Isolasi+aktinomisetes+%0D%0Adilakukan+menggunakan+metode+cawan+gores.+Isolat+aktinomisetes+di+identifikasi+%0D%0Asecara+makroskopik+dan+mikroskopik.+Kultivasi+aktinomisetes+dilakukan+pada+%0D%0Amedia+padat+kulit+udang+selama+14+hari.+Biomass+aktinomisetes+diekstrak+%0D%0Amenggunakan+etil+asetat+dan+dikarakterisasi+menggunakan+kromatografi+lapis+tipis+%0D%0A(KLT).+Skrining+aktivitas+antibakteri+dari+ekstrak+aktinomisetes+yang+dilakukan+%0D%0Amenggunakan+metode+microdilution+plate+terhadap+isolat+klinis+Staphylococcus+%0D%0Aaureus+dan+Pseudomonas+aureginosa.+Pemurnian+senyawa+dilakukan+dengan+%0D%0Akromatografi+kolom+dan+karakterisasi+dilakukan+menggunakan+instrumen+Liquid+%0D%0AChromatography-Mass+Spectrometry+(LC-MS%2FMS).+Berhasil+diisolasi+19+isolat+%0D%0Amikroba+endofit+mangrove.+Identifikasi+secara+makroskopis+dan+mikroskopis+%0D%0Amenunjukkan+hanya+6+isolat+yang+merupakan+aktinomisetes.+Isolat+22-PLP4-A1+%0D%0Amenunjukkan+aktivitas+antibakteri+yang+signifikan+terhadap+S.+aureus+dan+keenam+%0D%0Aisolat+tersebut+tidak+menunjukkan+aktivitas+antibakteri+terhadap+P.+aureginosa.%0D%0ATerpenoid+merupakan+komponen+dominan+dalam+ekstrak+berdasarkan+hasil+KLT+%0D%0Adengan+pereaksi+vanilin-asam+sulfat.+Kristal+FE-1d+sebanyak+10+mg+berhasil+%0D%0Adidapatkan+setelah+proses+pemurnian+dan+karakterisasi+menunjukkan+2+senyawa+%0D%0Autama+yang+terdapat+pada+kristal+tersebut+muncul+pada+waktu+retensi+12%2C40+dan+%0D%0A13%2C67+menit+merupakan+senyawa+turunan+benzilamin.+Berdasarkan+informasi+%0D%0Atersebut%2C+maka+penilitian+ini+telah+memberikan+informasi+mengenai+senyawa+yang+%0D%0Adihasilkan+oleh+AEM+dan+informasi+ini+dapat+digunakan+untuk+keperluan+lebih+%0D%0Alanjut+terkait+hubungan+struktur+senyawa+dengan+aktivitas+biologisnya.%0D%0A%0D%0AKata+Kunci+%3A+aktinomisetes+endofit+mangrove%2C+antibakteri%2C+Staphylococcus+aureus%2C+%0D%0APseudomonas+aureginosa%2C+benzilamin%0D%0A%0D%0A%0D%0AMangrove+endophytic+actinomycetes+(MEA)+are+known+to+have+the+potential+to+%0D%0Aproduce+bioactive+compounds+that+have+antibacterial+activity.+This+study+aims+to+%0D%0Aidentify+bioactive+compound+produced+by+MEA.+Actinomycetes+were+obtained+%0D%0Afrom+mangrove+plants+in+the+Petengoran+Mangrove+Forest%2C+Pesawaran%2C+Lampung.+%0D%0ASampling+was+carried+out+by+random+method+and+actinomycetes+enrichment+was+%0D%0Acarried+out+by+surface+sterilization+and+spread+plate+methods+on+1%25+chitin+colloidal+%0D%0Aagar+in+seawater.+Actinomycetes+isolation+was+carried+out+using+the+streak+plate+%0D%0Amethod.+Actinomycetes+isolates+were+identified+macroscopically+and+%0D%0Amicroscopically.+Actinomycetes+cultivation+was+carried+out+using+shrimp+shell+%0D%0Amedium+for+14+days.+The+cultivation+results+were+extracted+using+ethyl+acetate+and+%0D%0Acharacterized+using+thin-layer+chromatography+(TLC).+Antibacterial+screening+of%0D%0Aextracts+were+using+microdilution+plate+against+clinical+isolates+of+Staphylococcus+%0D%0Aaureus+and+Pseudomonas+aureginosa.+Compound+purification+by+column+%0D%0Achromatography+and+characterization+used+Liquid+Chromatography-Mass+%0D%0ASpectrometry+(LC-MS%2FMS)+instrument.+Total+of+19+isolates+of+mangrove+%0D%0Aendophytic+microbes+were+successfully+isolated.+Macroscopic+and+microscopic+%0D%0Aidentification+showed+that+6+isolates+were+actinomycetes.+Isolate+22-PLP4-A1+%0D%0Ashowed+significant+antibacterial+activity+against+S.+aureus+and+the+six+isolates+%0D%0Ashowed+no+antibacterial+activity+against+P.+aureginosa.+Terpenoids+are+the+dominant%0D%0Acomponent+in+the+extract+based+on+the+results+of+TLC+with+vanillin-sulfuric+acid+%0D%0Areagent.+After+the+purification+and+characterization+process%2C+10+mg+of+FE-1d+crystals+%0D%0Awas+obtained%2C+showing+that+the+2+main+compounds+present+in+the+crystals+appeared+%0D%0Aat+retention+time+of+12.40+and+13.67+minutes%2C+which+were+benzylamine+derivatives.%0D%0ABased+on+this+information%2C+this+research+has+provided+information+about+the+%0D%0Acompounds+produced+by+AEM+and+this+information+can+be+used+for+further+purposes+%0D%0Arelated+to+the+relationship+between+compound+structure+and+its+biological+activity.%0D%0A%0D%0AKeywords%3A+mangrove+endophytic+actinomycetes%2C+antibacterial%2C+Staphylococcus+%0D%0Aaureus%2C+Pseudomonas+aureginosa%2C+benzylamine%0D%0A%0D%0A&rft.publisher=FAKULTAS+MATEMATIKA+DAN+ILMU+PENGETAHUAN+ALAM&rft.date=2023-05-25&rft.type=Skripsi&rft.type=NonPeerReviewed&rft.format=text&rft.identifier=http%3A%2F%2Fdigilib.unila.ac.id%2F72410%2F1%2FABSTRAK.pdf&rft.format=text&rft.identifier=http%3A%2F%2Fdigilib.unila.ac.id%2F72410%2F3%2FSKRIPSI%2520DENGAN%2520BAB%2520PEMBAHASAN.pdf&rft.format=text&rft.identifier=http%3A%2F%2Fdigilib.unila.ac.id%2F72410%2F2%2FSKRIPSI%2520TANPA%2520BAB%2520PEMBAHASAN.pdf&rft.identifier=++Fatur%2C+Rohim++(2023)+INVESTIGASI+SENYAWA+BIOAKTIF+YANG+DIHASILKAN+OLEH+AKTINOMISETES+ENDOFIT+MANGROVE+SEBAGAI+ANTIBAKTERI+TERHADAP+BAKTERI+PATOGEN+RESISTEN.++FAKULTAS+MATEMATIKA+DAN+ILMU+PENGETAHUAN+ALAM%2C+UNIVERSITAS+LAMPUNG.+++++&rft.relation=http%3A%2F%2Fdigilib.unila.ac.id%2F72410%2F