?url_ver=Z39.88-2004&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Adc&rft.title=SINTESIS+DAN+KARAKTERISASI+SENYAWA+KOMPLEKS+Co(II)%E2%80%93+GLISIN%2C+Mn(II)%E2%80%93GLISIN+SERTA+UJI+ANTIDIABETES+TERHADAP+MENCIT+(Mus+musculus+L.)+DAN+UJI+IN+SILICO+PADA+PROTEIN+5DI1+&rft.creator=+LUTHFIA+PRITANIA+%2C+PUTRI+&rft.subject=500+ilmu+pengetahuan+alam+dan+matematika&rft.subject=540+Kimia+dan+ilmu+yang+berhubungan&rft.description=Diabetes++adalah++penyakit++yang++mempengaruhi++banyak++orang++di++seluruh++dunia.+Pengobatan++penyakit++diabetes++dapat++diobati++dengan++obat++berbahan++dasar++logam.+Penelitian++ini++dilakukan++untuk++memperoleh++kompleks++Co(II)-Glisin++dan++Mn(II)-+Glisin++dan++menguji++pengaruhnya++terhadap++gula++darah.++Sintesis++dilakukan++dengan+mereaksikan++CoCl2.6H2O++dan++MnCl2.4H2O++dengan++ligan++glisin++dan++hasil++yang+diperoleh++diujikan++pada++tikus++diabetes.++Reaksi++dengan++hasil++optimal++terjadi++pada+pH++4++dengan++waktu++4++jam++untuk++Co(II)-Glisin++dan++pH++5++dengan++waktu++4++jam+untuk++Mn(II)-Glisin++Hasil++sintesis++kompleks++Co++yaitu++padatan++berwarna++merah+jambu+dengan+rendemen+98%25%2C+sedangkan+untuk+kompleks+Mn+didapatkan+padatan+bening++dengan++rendemen++89%25.++++Hasil++sintesis++dikarakterisasi++dengan++menggunakan++spektrofotometer++UV-Vis++dan++spektrofotometer++IR.++++Hasil+spektrofotometer++UV-Vis++untuk++kompleks++Co++menunjukkan++adanya++serapan++pada+221++nm++dan++524++nm%2C++sedangkan++untuk++kompleks++Mn++terdapat++serapan++pada++202+nm++dan++567++nm.++++Hasil++karakterisasi++spektrofotometer++IR++Co(II)-Glisin+menunjukkan++bahwa++gugus++Co-N++terdapat++pada++daerah++693%2C3++cm-1%2C++sedangkan+Mn(II)-Glisin++memiliki++gugus++Mn-N++pada++daerah++685%2C8++cm-1.++++Hasil++uji++coba+antidiabetes+pada+27+ekor+tikus+menunjukkan+persentase+penurunan++glukosa+darah+terbaik++adalah++73%2C7%25++untuk++kompleks++Co++dengan++dosis++50++%C2%B5g%2FkgBB++dan++71%2C4%25+untuk++kompleks++Mn++dengan++dosis++150++%C2%B5g%2FkgBB.++berat.++++Senyawa++kompleks+Mn(II)-Glisin++juga++diuji++secara++in++silico++terhadap++protein++5DI1++dan++didapatkan+senyawa++kompleks++Mn(II)-Glisin++memiliki++nilai++energi++ikat++sebesar++-4%2C36+kkal.mol-1.++++Senyawa++kompleks++Co(II)-Glisin++dan++Mn(II)-Glisin++diuji++sebagai+kandidat++obat++dan++keduanya++memenuhi++syarat++secara++Lipinski%E2%80%99s++Rule++of++Five%2C+Swiss+ADME%2C+dan+ProTox.++%0D%0AKata+kunci+%3A+Senyawa+kompleks%2C+kobalt%2C+mangan%2C+glisin%2C+antidiabetes%2C+docking.%0D%0A%0D%0A%0D%0A+Diabetes++is++a++disease++that++affects++many++people++around++the++world.++Treatment++of+diabetes++can++be++treated++with++metal-based++drugs.++++This++research++was++conducted++to+obtain++Co(II)-Glycine++and++Mn(II)-Glycine++complexes++and++to++test++their++effect++on+blood+sugar.++Synthesis+was+carried+out+by+reacting+CoCl2.6H2O+and+MnCl2.4H2O+with++glycine++ligands++and++the++results++obtained++were++tested++on++diabetic++rats.++++The+reaction++with++optimal++results++occurred++at++pH++4++with++a+time++of++4++hours++for++Co(II)-+Glycine++and++pH++5++with++a++time++of++4++hours++for++Mn(II)-Glycine.++++The++result++of++the+synthesis++of++the++Co++complex++was++a++pink++solid++with++a++yield++of++98%25%2C++while++for+the+Mn++complex++a++clear++solid++was++obtained++with++a++yield++of++89%25.++++The++results++of++the+synthesis++were++characterized++using++UV-Vis++spectrophotometer++and++IR+spectrophotometer.++++UV-Vis++spectrophotometer++results++for++the++Co++complex+showed+absorption+at+221+nm+and+524+nm%2C+while+for+the+Mn+complex+there+were+absorptions++at++202++nm++and++567++nm.++++The++results++of++the++Co(II)-Glycine++IR+spectrophotometer+characterization+showed+that+the+Co-N+group+was+in+the+693.3+cm-1++area%2C++while++Mn(II)-Glycine++had++a++Mn-N++group++in++the++685.8++cm-1++area.++++The+results+of+the+antidiabetic+trial+on+27+rats+showed+that+the+best+percentage+of+blood+glucose++reduction++was++73.7%25++for++the++Co++complex++at++a++dose++of++50++%C2%B5g%2FkgBW++and+71.4%25++for++the++Mn++complex++at++a++dose++of++150++%C2%B5g%2FkgBW.++++The++Mn(II)-Glycine+complex+compound+was+also+tested+in+silico+against+5DI1+protein+and+it+was+found+that+the++Mn(II)-Glycine++complex++compound++had++a++binding++energy++value++of++-4.36+kcal.mol-1.+++Complex++compounds++Co(II)-Glycine++and++Mn(II)-Glycine++were+tested+as+drug+candidates+and+both+complied+with+Lipinski's+Rule+of+Five%2C+Swiss+ADME%2C+and+ProTox.+++Keywords%3A+Complex+compounds%2C+cobalt%2C+manganese%2C+glycine%2C+anti-diabetes%2C+docking.++&rft.publisher=FAKULTAS+MATEMATIKA+DAN+ILMU+PENGETAHUAN+ALAM+&rft.date=2023-05-31&rft.type=Skripsi&rft.type=NonPeerReviewed&rft.format=text&rft.identifier=http%3A%2F%2Fdigilib.unila.ac.id%2F72417%2F1%2F1.%2520ABSTRAK.pdf&rft.format=text&rft.identifier=http%3A%2F%2Fdigilib.unila.ac.id%2F72417%2F2%2F2.%2520SKRIPSI%2520FULL.pdf&rft.format=text&rft.identifier=http%3A%2F%2Fdigilib.unila.ac.id%2F72417%2F3%2F3.%2520SKRIPSI%2520TANPA%2520BAB%2520PEMBAHASAN.pdf&rft.identifier=+++LUTHFIA+PRITANIA+%2C+PUTRI+++(2023)+SINTESIS+DAN+KARAKTERISASI+SENYAWA+KOMPLEKS+Co(II)%E2%80%93+GLISIN%2C+Mn(II)%E2%80%93GLISIN+SERTA+UJI+ANTIDIABETES+TERHADAP+MENCIT+(Mus+musculus+L.)+DAN+UJI+IN+SILICO+PADA+PROTEIN+5DI1.++FAKULTAS+MATEMATIKA+DAN+ILMU+PENGETAHUAN+ALAM+%2C+UNIVERSITAS+LAMPUNG.+++++&rft.relation=http%3A%2F%2Fdigilib.unila.ac.id%2F72417%2F