?url_ver=Z39.88-2004&rft_id=1917011046&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Adc&rft.title=UJI+AKTIVITAS+ANTIDIABETES+SECARA+IN+SILICO+DAN+IN+VIVO%0D%0AEKSTRAK+METANOL+DAUN+SUNGKAI+(Peronema+canescens+Jack)%0D%0APADA+MENCIT+JANTAN+(Mus+musculus+L.)&rft.creator=QONITA+PUTRI+%2C+HAFIDHOH&rft.subject=500+ilmu+pengetahuan+alam+dan+matematika&rft.subject=540+Kimia+dan+ilmu+yang+berhubungan&rft.description=Diabetes+mellitus+merupakan+salah+satu+penyakit+yang+banyak+terjadi+di+Indonesia%2C%0D%0Ayang+ditandai+dengan+hiperglikemia.+Berbagai+upaya+mengatasi+penyakit+ini+terus%0D%0Adilakukan%2C+salah+satu+cara+untuk+mengatasi+diabetes+melitus+dengan+tanaman+obat%0D%0Aatau+herbal.+Tanaman+yang+dipercaya+masyarakat+dapat+mengobati+penyakit%0D%0Adiabetes+adalah+tanaman+sungkai.+Daun+sungkai+mengandung+senyawa+flavonoid%0D%0Ayang+dapat+menurunkan+kadar+glukosa+darah+dengan+kemampuannya+sebagai+zat%0D%0Aantioksidan.+Pada+penelitian+ini+uji+aktivitas+antidiabetes+dilakukan+secara+in%0D%0Asilico+dan+in+vivo.+Metode+yang+dilakukan+yaitu+dengan+menganalisis+keberadaan%0D%0Asenyawa+flavonoid+dengan+skrining+fitokimia%2C+KLT%2C+KLTP%2C+dan+dikarakterisasi%0D%0Adengan+UV-Vis+dan+FTIR%2C+kemudian+dilakukan+docking+senyawa+turunan%0D%0Aflavonoid+dengan+protein+1GFY+serta+diuji+farmakokinetiknya.+Pengujian+secara%0D%0Ain+vivo+dilakukan+menggunakan+mencit+jantan+sebanyak+18+ekor.+Hasil%0D%0Akarakterisasi+dengan+UV-Vis+dan+FTIR+menunjukkan+adanya+senyawa+flavonoid%0D%0Ajenis+kaempferol.+Hasil+uji+secara+in+silico+menunjukkan+bahwa+senyawa%0D%0Akaempferol+merupakan+senyawa+dengan+hasil+docking+terbaik+dengan+energi%0D%0Aikatan+sebesar+-9%2C67+serta+memenuhi+syarat+sebagai+kandidat+obat+antidiabetes%0D%0Asecara+Lipinski+Rule+of+Five%2C+SwissADME%2C+dan+Protox.+Hasil+uji+secara+in+vivo%0D%0Amenunjukkan+persentase+penurunan+kadar+glukosa+darah+mencit+terbaik+yaitu%0D%0A70%2C36%25+untuk+dosis+400+mg%2Fkg+BB.+Pengolahan+data+menggunakan+One-way%0D%0AANOVA+dan+dilanjutkan+BNT+pada+taraf+nyata+5%25+menghasilkan+nilai+yang%0D%0Asignifikan+yaitu+p+%E2%89%A4+0%2C05.+Berdasarkan+hasil+yang+telah+didapat+diketahui+bahwa%0D%0Aekstrak+metanol+daun+sungkai+mengandung+senyawa+flavonoid+yang+dapat%0D%0Adigunakan+sebagai+senyawa+antidiabetes.%0D%0A%0D%0AKata+kunci%3A+antidiabetes%2C+daun+sungkai%2C+flavonoid%2C+molecular+docking%2C+mencit.%0D%0A%0D%0A%0D%0A%0D%0A%0D%0A%0D%0Aabstract%0D%0A%0D%0ADiabetes+mellitus+is+one+of+various+disease+that+often+occurs+in+Indonesia%2C+is%0D%0Acharacterized+by+hyperglycemia.+Various+efforts+to+overcome+this+disease+continue%0D%0Ato+be+made%2C+one+of+the+ways+to+overcome+diabetes+mellitus+is+with+medicinal%0D%0Aplants+or+herbs.+Plants+that+people+believe+can+treat+diabetes+is+sungkai+plants.%0D%0ASungkai+leaves+contain+flavonoid+compounds+that+can+reduce+blood+glucose+levels%0D%0Awith+their+ability+as+antioxidants.+In+this+study%2C+the+activity+of+atidiabetes+was%0D%0Atested+in+silco+and+in+vivo+sera.+The+method+used+was+to+analyze+the+presence+of%0D%0Aflavonoid+compounds+by+screening+phytochemicals%2C+TLC%2C+TLC+preparative%2C+and%0D%0Acharacterization+with+UV-Vis+and+FTIR%2C+then+docking+the+flavonoid+derivative%0D%0Acompounds+with+1GFY+protein+and+testing+their+pharmacokietics.+In+vivo+testing%0D%0Awas+carried+out+with+18+male+mice.+The+results+of+characterization+with+UV-Vis%0D%0Aand+FTIR+showed+the+presence+of+kaempferol-type+flavonoid+compounds.+The%0D%0Aresults+of+the+in+silico+test+showed+that+kaempferol+was+the+compound+with+the%0D%0Abest+docking+results+with+a+bond+energy+of+-9.67+and+met+the+requirements+as+a%0D%0Acandidate+for+anti-diabetic+drugs+according+to+the+Lipinski+Rule+of+Five%2C%0D%0ASwissADME%2C+and+Protox.+The+in+vivo+test+results+showed+that+the+best+proportion%0D%0Aof+mice+blood+glucose+reduction+was+70.36%25+for+a+dose+of+400+mg%2Fkg+BW.+Data%0D%0Aprocessing+using+One-way+ANOVA+and+continued+BNT+at+5%25+significance+level%0D%0Aresulted+in+a+significant+value%2C+namely+p+%E2%89%A4+0.05.+Based+on+the+results+obtained%2C+it+is%0D%0Aknown+that+the+methanol+extract+of+Sungkai+leaves+contains+flavonoid+compounds%0D%0Awhich+can+be+used+as+antidiabetic+compounds.%0D%0A%0D%0AKeywords%3A+antidiabetic%2C+sungkai+leaves%2C+flavonoids%2C+molecular+docking%2C+mice.&rft.publisher=FAKULTAS+MATEMATIKA+DAN+ILMU+PENGETAHUAN+ALAM+&rft.date=2023-05-30&rft.type=Skripsi&rft.type=NonPeerReviewed&rft.format=text&rft.identifier=http%3A%2F%2Fdigilib.unila.ac.id%2F72427%2F1%2FABSTRAK.pdf&rft.format=text&rft.identifier=http%3A%2F%2Fdigilib.unila.ac.id%2F72427%2F2%2FSKRIPSI%2520FULL.pdf&rft.format=text&rft.identifier=http%3A%2F%2Fdigilib.unila.ac.id%2F72427%2F3%2FSKRIPSI%2520TANPA%2520BAB%2520PEMBAHASAN.pdf&rft.identifier=++QONITA+PUTRI+%2C+HAFIDHOH++(2023)+UJI+AKTIVITAS+ANTIDIABETES+SECARA+IN+SILICO+DAN+IN+VIVO+EKSTRAK+METANOL+DAUN+SUNGKAI+(Peronema+canescens+Jack)+PADA+MENCIT+JANTAN+(Mus+musculus+L.).++FAKULTAS+MATEMATIKA+DAN+ILMU+PENGETAHUAN+ALAM+%2C+UNIVERSITAS+LAMPUNG.+++++&rft.relation=http%3A%2F%2Fdigilib.unila.ac.id%2F72427%2F