?url_ver=Z39.88-2004&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Adc&rft.title=Isolasi%2C+Karakterisasi%2C+Serta+Uji+Bioaktivitas+%0D%0AAntidiabetes+Dan+Antibakteri+Senyawa+Flavonoid+Dari+%0D%0AKayu+Akar+Tumbuhan+Kenangkan+(Artocarpus+rigida+Blume)&rft.creator=Kania%2C+Nur+Aisyah&rft.subject=540+Kimia+dan+ilmu+yang+berhubungan&rft.description=Diabetes+mellitus+merupakan+penyakit+metabolisme+yang+disebabkan+dengan+%0D%0Akenaikan+kadar+gula+darah+yang+melebihi+batas+normal+sehingga+dapat+%0D%0Amenyebabkan+kelainan+dan+infeksi+dalam+tubuh.+Penelitian+ini+bertujuan+untuk+%0D%0Amengisolasi%2C+mengidentifikasi%2C+dan+menguji+bioaktivitas+antidiabetes+dan+antibakteri+%0D%0Apada+senyawa+flavonoid+hasil+isolasi.+Isolasi+dari+senyawa+flavonoid+menggunakan+%0D%0Ametode+ekstraksi+dengan+maserasi+yang+dilanjutkan+pemurnian+dengan+metode+%0D%0AKCV+dan+KK.+Telah+berhasil+diisolasi+senyawa+flavonoid+berdasarkan+uji+%0D%0Akemurnian+dengan+uji+fisika+dan+penentuan+struktur+senyawa+menggunakan+%0D%0Aspektroskopi+UV-Vis+dan+IR+yaitu+senyawa+artokarpin+sebanyak+50+mg+dan+%0D%0Asenyawa+sikloartokarpin+sebanyak+2%2C4+mg+berupa+kristal+bewarna+kuning.+Uji+%0D%0Abiaktivitas+antidiabetes+terhadap+senyawa+isolasi+artokarpin+menunjukkan+%0D%0Apenghambatan+terhadap+senyawa+hasil+isolasi+sebesar+64%2C12%25+pada+konsentrasi+%0D%0A2000+ppm+lebih+rendah+dari+kontrol+positif+akarbosa+sebesar+88%2C20%25+pada+%0D%0Akonsentrasi+yang+sama.+Dilakukan+juga+uji+antidiabetes+terhadap+senyawa+%0D%0Amodifikasi+dari+artokarpin+dengan+penghambatan+sebesar+93%2C92+%25+lebih+besar+dari+%0D%0Akontrol+akarbosa+sebesar+90%2C68%25+dan+senyawa+artokarpin+pada+konsentrasi+1000+%0D%0Appm.+Senyawa+ini+juga+menunjukkan+aktivitas+antibakteri+dalam+kategori+kuat+%0D%0Aterhadap+bakteri+Salmonella+sp+dan+S.aureus+pada+konsentrasi+0%2C5+dan+0%2C4+mg%2Fdisk%2C+%0D%0Aserta+menunjukkan+aktivitas+dalam+kategori+sedang+pada+konsentrasi+0%2C3+mg%2Fdisk.%0D%0AKata+kunci+%3A+A.+rigida+blume%2C+flavonoid%2C+artokarpin%2C+sikloartokarpin%2C+antidiabetes%2C+%0D%0Aantibakteri%0D%0A%0D%0AISOLATION%2C+CHARACTERIZATION%2C+AND+BIOACTIVITY+TEST+OF+%0D%0AANTI-DIABETIC+AND+ANTI-BACTERIAL+FLAVONOID+COMPOUND%0D%0AFROM+THE+ROOT+WOOD+OF+KENANGKAN+PLANT+(Artocarpus+rigida+%0D%0ABlume)%0D%0ABy%0D%0AKANIA+NUR+AISYAH%0D%0ADiabetes+mellitus+is+a+metabolic+disease+caused+by+an+increase+in+blood+sugar+%0D%0Alevels+that+exceed+normal+limits+so+that+it+can+cause+disorders+and+infections+in+the+%0D%0Abody.+This+study+aims+to+isolate%2C+identify%2C+and+test+the+anti-diabetic+and+anti%EF%BF%BDbacterial+bioactivity+of+isolated+flavonoid+compounds.+Isolation+of+the+flavonoids+%0D%0Aused+the+extraction+method+with+maceration+followed+by+purification+using+the+%0D%0AKCV+and+KK+methods.+Flavonoids+have+been+successfully+isolated+based+on+%0D%0Apurity+tests+with+physical+tests+and+structural+determination+of+compounds+using+%0D%0AUV-Vis+and+IR+spectroscopy%2C+are+consisted+50+mg+of+artocarpine+and+2.4+mg+of+%0D%0Acycloartocarpine+in+the+form+of+yellow+crystals.+The+antidiabetic+biactivity+test+of+%0D%0Aartocarpine+isolated+compound+showed+inhibition+of+the+isolated+compound+of+%0D%0A64.12%25+at+a+concentration+of+2000+ppm+which+was+lower+than+the+positive+control+%0D%0Aof+acarbose+of+88.20%25+at+the+same+concentration.+An+anti-diabetic+test+was+also+%0D%0Acarried+out+on+a+modified+compound+of+artocarpine+with+an+inhibition+of+93.92%25+%0D%0Agreater+than+that+of+the+control+acarbose+of+90.68%25+and+the+compound+artocarpine+%0D%0Aat+a+concentration+of+1000+ppm.+This+compound+also+showed+anti-bacterial+%0D%0Aactivity+in+strong+category+against+Salmonella+sp+and+S.aureus+bacteria+at+%0D%0Aconcentrations+of+0.5+and+0.4+mg%2Fdisc%2C+and+showed+activity+in+the+moderate+%0D%0Acategory+at+concentrations+of+0.3+mg%2Fdisc.%0D%0AKata+kunci+%3A+A.+rigida+blume%2C+flavonoid%2C+artocarpin%2C+cycloartocarpin%2C+anti%EF%BF%BDdiabetic%2C+anti-bacterial.&rft.publisher=Matematika+dan+Ilmu+Pengetahuan+Alam&rft.date=2023-05-30&rft.type=Skripsi&rft.type=NonPeerReviewed&rft.format=text&rft.identifier=http%3A%2F%2Fdigilib.unila.ac.id%2F72555%2F1%2FABSTRAK.pdf&rft.format=text&rft.identifier=http%3A%2F%2Fdigilib.unila.ac.id%2F72555%2F3%2FSkripsi%2520dengan%2520Bab%2520Pembahasan.pdf&rft.format=text&rft.identifier=http%3A%2F%2Fdigilib.unila.ac.id%2F72555%2F2%2FSkripsi%2520tanpa%2520Bab%2520Pembahasan.pdf&rft.identifier=++Kania%2C+Nur+Aisyah++(2023)+Isolasi%2C+Karakterisasi%2C+Serta+Uji+Bioaktivitas+Antidiabetes+Dan+Antibakteri+Senyawa+Flavonoid+Dari+Kayu+Akar+Tumbuhan+Kenangkan+(Artocarpus+rigida+Blume).++Matematika+dan+Ilmu+Pengetahuan+Alam%2C+Universitas+Lampung.+++++&rft.relation=http%3A%2F%2Fdigilib.unila.ac.id%2F72555%2F