?url_ver=Z39.88-2004&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Adc&rft.title=+POTENSI+EKSTRAK+ETANOL+Halimeda+opuntia+DAN+TAURIN+SEBAGAI+SENYAWA+SITOTOKSIK+TERHADAP+Artemia+salina+DENGAN++METODE+BRINE+SHRIMP+LETHALITY+TEST+(BSLT)+&rft.creator=KEZIA+%2C+ANYNDA&rft.subject=001+Ilmu+pengetahuan&rft.subject=500+ilmu+pengetahuan+alam+dan+matematika&rft.subject=570+Biologi&rft.description=++Kanker+merupakan+salah+satu+penyebab+kematian+yang+banyak+terjadi+di+Indonesia.+Beberapa+pengobatan+yang+dilakukan+untuk+menyembuhkan+kanker+seperti+operasi%2C+kemoterapi%2C++terapi++radiasi%2C++imunoterapi%2C++dan++terapi++hormon++membutuhkan++biaya+yang+cukup+tinggi.+Sehingga+diperlukan+pengobatan+lain+dengan+biaya+yang+lebih+murah%2C+salah+satunya+dengan+menggunakan+taurin+dan+pemanfaatan+sumber+daya+alam++laut++yaitu++makroalga++Halimeda++opuntia.++Taurin++dan++Halimeda++opuntia+diketahui+memiliki+kandungan+senyawa+yang+berperan+dalam+memberikan+aktivitas+antioksidan.++Penelitian++ini++bertujuan++untuk++menguji++potensi++taurin++dan++senyawa+bioaktif+pada+ekstrak+etanol+Halimeda+opuntia+sebagai+senyawa+sitotoksik+terhadap+larva++Artemia++salina++menggunakan++Brine++Shrimp++Lethality++Test++(BSLT).++Pada+penelitian++ini++digunakan++Rancangan+Acak++Lengkap++(RAL)++dengan++faktorial++2x4.+Penelitian++dilakukan++dengan++menguji++dua++faktor++yaitu++taurin++dan++ekstrak++etanol+Halimeda++opuntia.++Konsentrasi++uji++yang++digunakan++pada++penelitian++ini++yaitu++100+ppm%2C+250+ppm%2C+500+ppm%2C+dan+1000+ppm.+Masing-masing+konsentrasi+uji+dilakukan+pengulangan+sebanyak+lima+kali.+Nilai+LC50+ditentukan+dengan+analisis+probit+pada+aplikasi+SPSS.+Selanjutnya+dilakukan+pengujian+kembali+terhadap+larutan+uji+taurin+dan+ekstrak+etanol+Halimeda+opuntia+dengan+mencampur+kedua+larutan+uji+tersebut+menggunakan++konsentrasi++berdasarkan++nilai++LC50++yang++telah++dianalisis++pada++uji+sebelumnya.+Hasil+penelitian+menunjukkan+bahwa+ekstrak+etanol+Halimeda+opuntia+positif++mengandung++senyawa++bioaktif++saponin%2C++terpenoid%2C++tanin%2C++alkaloid++dan+flavonoid.+Nilai+LC50+dari+taurin+yaitu+sebesar+311+ppm+dan+ekstrak+etanol+Halimeda+opuntia+yaitu+sebesar+260+ppm+yang+berarti+kedua+larutan+uji+memiliki+sifat+toksik+serta+berpotensi+sebagai+antikanker.+Selanjutnya+terdapat+perbedaan+yang+signifikan+terhadap+rata-rata+kematian+larva+Artemia+salina+antara+larutan+campuran+dengan+larutan++taurin++konsentrasi++311++ppm++dan++antara++larutan++campuran++dengan++ekstrak+etanol+Halimeda+opuntia+konsentrasi+260+ppm.++Kata+kunci%3A+antikanker%2C+antioksidan%2C+H.+opuntia%2C+A.+salina%2C+Brine+Shrimp+Lethality+Test+(BSLT)++%0D%0ACancer++is++one++of++the++most++common++causes++of++death++in++Indonesia.++Some++of++the+treatments+used+to+cure+cancer%2C+such+as+surgery%2C+chemotherapy%2C+radiation+therapy%2C+immunotherapy%2C++and++hormone++therapy%2C++have++quite++high++costs.++So++that++other+treatments+are+needed+at+a+lower+cost%2C+such+as+using+taurine+and+the+utilization+of+marine++natural++resources%2C++namely++macroalgae++Halimeda++opuntia.++Taurine++and+Halimeda+opuntia+are+known+to+contain+compounds+that+play+a+role+in+providing+antioxidant++activity.++This++study++aims++to++examine++the++potential++of++taurine++and+bioactive++compounds++in++the++ethanol++extract++of++Halimeda++opuntia++as++cytotoxic+compounds++against++Artemia++salina++larvae++using++the++Brine++Shrimp++Lethality++Test+(BSLT).++In++this++study%2C++a++completely++randomized++design++with++a++2x4++factorial++was+used.++The++study++was++conducted++by++testing++two++factors%2C++namely++taurine++and++the+ethanol++extract++of++Halimeda++opuntia.++The++concentrations++used++in++this++study++were+100+ppm%2C+250+ppm%2C+500+ppm%2C+and+1000+ppm.+Each+concentration+was+repeated+five+times.+The+LC50+value+was+determined+by+probit+analysis+in+the+SPSS+application.+Furthermore%2C+the+Brine+Shrimp+Lethality+Test+(BSLT)+was+repeated+on+the+taurine+and+the+ethanol+extract+of+Halimeda+opuntia+by+combining+the+two+test+materials+at+a+concentration+based+on+the+LC50+value+determined+in+the+previous+test.+The+results+showed+that+the+ethanol+extract+of+Halimeda+opuntia+positively+contained+saponins%2C+terpenoids%2C+tannins%2C+alkaloids%2C+and+flavonoids.+The+LC50+value+of+taurine+is+311+ppm%2C+while+the+ethanol+extract+of+Halimeda+opuntia+is+260+ppm%2C+indicating+that+both+test+materials+are+toxic+and+have+the+potential+to+be+anticancer.+There+was+a+significant+difference+in+the+average+mortality+of+Artemia+salina+larvae+between+the+combined+test++material++and++a++taurine++concentration++of++311++ppm%2C++as++well++as++between++the+combined+test+material+and+a+Halimeda+opuntia+ethanol+extract+concentration+of+260+ppm.+%0D%0A+Keywords%3A+anticancer%2C+antioxidant%2C+H.+opuntia%2C+A.+salina%2C+Brine+Shrimp+Lethality+Test+(BSLT)+++&rft.publisher=FAKULTAS+MATEMATIKA+DAN+ILMU+PENGETAHUAN+ALAM&rft.date=2023-08-14&rft.type=Skripsi&rft.type=NonPeerReviewed&rft.format=text&rft.identifier=http%3A%2F%2Fdigilib.unil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