?url_ver=Z39.88-2004&rft_id=1814221034+&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Adc&rft.title=IDENTIFIKASI+SENYAWA+AKTIF+DAN+PREDIKSI+MOLEKULER%0D%0ASENYAWA+ANTIKANKER+PAYUDARA+PADA+SPONS+Stylissa+massa+(Carter%2C+1887)+&rft.creator=CAROLINE+%2C+LYDIA+AULIA+&rft.subject=630+Pertanian+dan+teknologi+yang+berkaitan&rft.description=Spons+mewakili+sumber+keanekaragaman+hayati+yang+besar%2C+memainkan+peran%0D%0Apenting+dalam+farmakologi+kelautan.+yaitu+bidang+studi+yang+memadukan+bioteknologi+biru+dan+farmakologi+senyawa+alami.+Spesies+spons+Stylissa+massa+diketahui+memiliki+bioaktif+yang+dapat+dimanfaatkan%2C+salah+satunya+ialah+sebagai+senyawa+antikanker.+Kanker+payudara+termasuk+urutan+kedua+penyebab+kematian+terbanyak+di+Indonesia.+Telah+dilakukan+penelitian+senyawa+spons+S.+massa+yang+diperoleh+dari+perairan+Pulau+Pahawang%2C+Lampung%2C+Indonesia.+Tujuan+dari+penelitian+adalah+mengidentifikasi+senyawa+aktif+S.+massa+yang+berperan+sebagai+antikanker+payudara.+Metode+penelitian+yang+digunakan+adalah+analisis+LC-HRMS%0D%0Adan+molecular+docking.+Hasil+dari+penelitian+menunjukkan+nilai+binding+affinity%0D%0Ayang+baik+dari+docking+senyawa+asam+flufenamat+dengan+protein+target+kanker+payudara+CSF1R%2C+PLK4%2C+MKNK2%2C+dan+ABL1+dibandingkan+dengan+senyawa+hymenamide+C+dengan+protein+target+kanker+payudara+GRB2+dan+OXTR.+Nilai%0D%0ARMSD+yang+baik+juga+ditunjukkan+oleh+senyawa+asam+flufenamat+dengan+ligan%0D%0Aasli+masing-masing+protein+target+di+mana+nilai+RMSD+mendekati+0%C3%85.+Hasil+penelitian+dapat+disimpulkan+bahwa+terdapat+2+senyawa+aktif+S.+massa+yang+berpotensi+sebagai+antikanker+payudara+(asam+flufenamat+dan+hymenamide+C)+dari+setidaknya+12+senyawa+antikanker.+Senyawa+tersebut+diprediksi+memiliki+mekanisme%0D%0Amolekuler+sebagai+inhibitor+pada+protein+target+kanker+payudara.%0D%0AKata+kunci%3A+Stylissa+massa%2C+kanker+payudara%2C+molecular+docking%2C+LC-HRMS%2C+in%0D%0Asilico%0D%0A%0D%0A%0D%0AA+great+source+of+biodiversity%2C+sponges+play+an+important+role+in+marine+pharmacology%2C+a+scientific+field+combining+blue+biotechnology+and+natural+products+pharmacology.+Stylissa+massa+sponge+species+consist+of+usable+bioactives%2C+one+of%0D%0Awhich+is+an+anticancer+agent.+Breast+cancer+is+the+second+leading+cause+of+mortality+in+Indonesia.+Stylissa+massa+compounds+from+the+Pahawang+Island+waters%2C%0D%0ALampung%2C+Indonesia+were+investigated.+This+study+aimed+to+identify+active+compounds+from+S.+massa+which+had+anti-cancer+activity+potential+in+breast+cancer.%0D%0ALC-HRMS+analysis+and+molecular+docking+were+used+as+the+research+method+of%0D%0Ainvestigation.+The+results+showed+that+compared+to+the+docked+hymenamide+C%0D%0Awith+the+breast+cancer+target+proteins+GRB2+and+OXTR%2C+the+docked+flufenamic%0D%0Aacid+had+a+better+binding+affinity+value+with+the+breast+cancer+target+proteins%0D%0ACSF1R%2C+PLK4%2C+MKNK2+and+ABL1.+The+flufenamic+acid+also+showed+better%0D%0ARMSD+with+the+native+ligand+of+each+target+protein%2C+with+RMSD+close+to+0%C3%85.+In%0D%0Abrief%2C+there+were+out+of+at+least+12+anticancer+compounds+from+S.+massa%2C+2+of+them%0D%0Ahad+potential+as+anti-breast+cancer+agents+(flufenamic+acid+and+hymenamide+C).%0D%0AThese+compounds+may+had+molecular+mechanisms+as+inhibitors+of+breast+cancer%0D%0Atarget+proteins.%0D%0AKeywords%3A+Stylissa+massa%2C+breast+cancer%2C+molecular+docking%2C+LC-HRMS%2C+in+silico.&rft.publisher=FAKULTAS+PERTANIAN&rft.date=2023-06-14&rft.type=Skripsi&rft.type=NonPeerReviewed&rft.format=text&rft.identifier=http%3A%2F%2Fdigilib.unila.ac.id%2F75937%2F1%2FABSTRAK.pdf&rft.format=text&rft.identifier=http%3A%2F%2Fdigilib.unila.ac.id%2F75937%2F2%2FSKRIPSI%2520FULL.pdf&rft.format=text&rft.identifier=http%3A%2F%2Fdigilib.unila.ac.id%2F75937%2F3%2FSKRIPSI%2520TANPA%2520BAB%2520PEMBAHASAN.pdf&rft.identifier=++CAROLINE+%2C+LYDIA+AULIA+++(2023)+IDENTIFIKASI+SENYAWA+AKTIF+DAN+PREDIKSI+MOLEKULER+SENYAWA+ANTIKANKER+PAYUDARA+PADA+SPONS+Stylissa+massa+(Carter%2C+1887).++FAKULTAS+PERTANIAN%2C+UNIVERSITAS+LAMPUNG.+++++&rft.relation=http%3A%2F%2Fdigilib.unila.ac.id%2F75937%2F