?url_ver=Z39.88-2004&rft_id=1917051014&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Adc&rft.title=KLASIFIKASI+ASETILASI+DAN+METILASI+PADA+DNA+RAGI%0D%0AMENGGUNAKAN+METODE+LONG+SHORT-TERM+MEMORY+(LSTM)&rft.creator=MOHAMMAD+%2C+FAJAR+&rft.subject=000+Ilmu+komputer%2C+informasi+dan+pekerjaan+umum&rft.subject=500+ilmu+pengetahuan+alam+dan+matematika&rft.description=DNA+merupakan+molekul+di+dalam+sel+yang+mengandung+informasi+genetik+yang%0D%0Abertanggung+jawab+atas+perkembangan+dan+fungsi+suatu+organisme.+DNA%0D%0Amerupakan+sebuah+cetak+biru+untuk+membuat+protein.+Terdapat+protein+yang%0D%0Adisebut+Histone.+Histone+terdiri+dari+empat+jenis%2C+yaitu+H2A%2C+H2B%2C+H3%2C+dan+H4+dan%0D%0Abiasanya+DNA+berada+di+sekeliling+Histone.+DNA+sebagai+struktur+dasar+pembentuk%0D%0Aprotein%2C+pada+prosesnya+akan+terjadi+proses+transkripsi+yang+mengubah+DNA%0D%0Amenjadi+RNA+kemudian+menjadi+protein.+Pada+protein+terjadi+modifikasi+pada+asam%0D%0Aamino+saat+proses%2C+yaitu+Asetilasi+dan+Metilasi.+Pada+Tahun+2005+dilakukan%0D%0Apenelitian+mengenai+klasifikasi+DNA+oleh+Pokholok+et+al.%2C+dan+didapatkan+data%0D%0ADNA+dari+organisme+Ragi.+Data+tersebut+berisikan+sekuens+DNA+ada+atau+tidaknya%0D%0AHistone+atau+modifikasi+DNA.+Untuk+melakukan+klasifikasi+DNA+diperlukan%0D%0Asumber+daya+yang+besar+sehingga+untuk+mengatasi+hal+tersebut+digunakanlah%0D%0Ametode+komputasi.+Penelitian+ini+akan+dilakukan+pengklasifikasian+biner+terhadap%0D%0ADNA+Ragi.+DNA+Ragi+akan+diklasifikasikan+dengan+menentukan+apakah+terdapat%0D%0AHistone%2C+terjadi+Asetilasi+atau+Metilasi.+Metode+yang+digunakan+adalah+Long+Short-%0D%0ATerm+Memory+(LSTM).+Penelitian+ini+bertujuan+untuk+melakukan+Experiment%0D%0Aseberapa+baik+kinerja+pengklasifikasian+secara+spasial+pada+data+DNA.+Dataset%0D%0Ayang+digunakan+diperoleh+dari+penelitian+Pokholok+et+al.%2C+(2005)+yang+berisikan%0D%0Asepuluh+dataset.+Setiap+dataset+memiliki+dua+kelas%2C+yaitu+positif+dan+negatif.%0D%0APembagian+data+dilakukan+dengan+skenario%2C+yaitu+80%25+training+dan+20%25+testing.%0D%0AEvaluasi+model+dilakukan+menggunakan+Confusion+Matrix+dengan+metrik+evaluasi%0D%0Ayang+digunakan+yaitu+Accuracy%2C+Precision%2C+dan+Recall.+Hasil+klasifikasi+DNA+Ragi%0D%0Aterbaik+didapatkan+dari+Experiment+4+yang+memiliki+rerata+Accuracy+Pengujian%0D%0Ayang+terbaik+dengan+rerata+Accuracy+sebesar+63%2C10%25%2C+Precision+sebesar+62%2C95%25%2C%0D%0Adan+Recall+sebesar+77%2C80%25.%0D%0AKata+Kunci%3A+DNA+Ragi%2C+Histone%2C+Asetilasi+dan+Metilasi%2C+LSTM.%0D%0A%0D%0ADNA+is+a+molecule+inside+cells+that+contains+genetic+information+responsible+for+the%0D%0Adevelopment+and+function+of+an+organism.+DNA+is+a+blueprint+for+making+proteins.%0D%0AThere+are+proteins+called+Histones.+Histone+consists+of+four+types%2C+namely+H2A%2C%0D%0AH2B%2C+H3%2C+and+H4+and+usually+DNA+is+around+Histone.+DNA+as+the+basic+structure%0D%0Aof+protein+formation%2C+in+the+process+there+will+be+a+transcription+process+that%0D%0Aconverts+DNA+into+RNA+and+then+into+protein.+In+proteins%2C+there+are+modifications%0D%0Ato+amino+acids+during+the+process%2C+namely+acetylation+and+methylation.+In+2005%2C%0D%0Aresearch+was+conducted+on+DNA+classification+by+Pokholok+et+al.%2C+and+obtained%0D%0ADNA+data+from+yeast+organisms.+The+data+contains+DNA+sequences+of+the+presence%0D%0Aor+absence+of+Histone+or+DNA+modifications.+To+perform+DNA+classification%2C+large%0D%0Aresources+are+needed+so+that+to+overcome+this%2C+computational+methods+are+used.%0D%0AThis+research+will+do+a+binary+classification+of+yeast+DNA.+Yeast+DNA+will+be%0D%0Aclassified+by+determining+whether+there+is+Histone%2C+Acetylation+or+Methylation.+The%0D%0Amethod+used+is+Long+Short-Term+Memory+(LSTM).+This+research+aims+to%0D%0Aexperiment+how+well+the+spatial+classification+performance+on+DNA+data.+The%0D%0Adataset+used+is+obtained+from+the+research+of+Pokholok+et+al.%2C+(2005)+which+contains%0D%0Aten+datasets.+Each+dataset+has+two+classes%2C+namely+positive+and+negative.+Data%0D%0Adivision+is+done+by+scenario%2C+which+is+80%25+training+and+20%25+testing.+Model%0D%0Aevaluation+is+done+using+Confusion+Matrix+with+evaluation+metrics+used%2C+namely%0D%0AAccuracy%2C+Precision%2C+and+Recall.+The+best+Yeast+DNA+classification+results+were%0D%0Aobtained+from+Experiment+4+which+had+the+best+average+Testing+Accuracy+with+an%0D%0Aaverage+Accuracy+of+63.10%25%2C+Precision+of+62.95%25%2C+and+Recall+of+77.80%25.%0D%0AKeywords%3A+Yeast+DNA%2C+Histone%2C+Acetylation+and+Methylation%2C+LSTM.&rft.publisher=FAKULTAS+MATEMATIKA+DAN+ILMU+PENGETAHUAN+ALAM&rft.date=2023-12-04&rft.type=Skripsi&rft.type=NonPeerReviewed&rft.format=text&rft.identifier=http%3A%2F%2Fdigilib.unila.ac.id%2F78064%2F1%2FABSTRAK.pdf&rft.format=text&rft.identifier=http%3A%2F%2Fdigilib.unila.ac.id%2F78064%2F3%2FSKRIPSI%2520FULL.pdf&rft.format=text&rft.identifier=http%3A%2F%2Fdigilib.unila.ac.id%2F78064%2F2%2FSKRIPSI%2520TANPA%2520BAB%2520PEMBAHASAN.pdf&rft.identifier=++MOHAMMAD+%2C+FAJAR+++(2023)+KLASIFIKASI+ASETILASI+DAN+METILASI+PADA+DNA+RAGI+MENGGUNAKAN+METODE+LONG+SHORT-TERM+MEMORY+(LSTM).++FAKULTAS+MATEMATIKA+DAN+ILMU+PENGETAHUAN+ALAM%2C+UNIVERSITAS+LAMPUNG.+++++&rft.relation=http%3A%2F%2Fdigilib.unila.ac.id%2F78064%2F