@misc{eprints81327,
           month = {Desember},
           title = {ANALISIS KORELASI KADAR HEMOGLOBIN A2 DENGAN INDEKS
ERITROSIT PADA PASIEN BETA-THALASSEMIA DI RSUD DR. H.
ABDUL MOELOEK PROVINSI LAMPUNG TAHUN 2023
},
          author = { QORIBA  FATHAN },
         address = {UNIVERSITAS LAMPUNG},
       publisher = {FAKULTAS KEDOKTERAN},
            year = {2024},
             url = {http://digilib.unila.ac.id/81327/},
        abstract = {Introduction: Thalassemia is a genetic disorder that disrupts hemoglobin
production. Hemoglobin undergoes destruction due to abnormalities in the
synthesis of hemoglobin or globin chains. This study aims to explore the
correlation between hemoglobin A2 (HbA2) levels and erythrocyte indices in
thalassemia patients at Dr. H. Abdul Moeloek Regional General Hospital,
Lampung Province, in 2023.
Methods: This research employed an analytical observational study with a crosssectional
approach
using
a
total
sampling
technique.
The
sample
consisted
of
39

beta-thalassemia
patients
who
met
the
inclusion
and
exclusion
criteria.
The
study

was

conducted from September to November 2024 in the Medical Records
Department of Dr. H. Abdul Moeloek Regional General Hospital, Lampung
Province. Data were analyzed using univariate and bivariate methods, with
Spearman's correlation test used to determine the relationship between HbA2
levels and each erythrocyte index.
Results:  The majority of subjects showed elevated HbA2 levels (66.7\%) and
decreased MCV (97.4\%) and MCH (92.3\%) levels. A significant correlation was
found between HbA2 levels and MCV (p = 0.001; r = -0.525) as well as between
HbA2 levels and MCH (p = 0.001; r = -0.508).
Conclusion: This study demonstrates that elevated HbA2 levels correlate with
decreased MCV and MCH values in beta-thalassemia patients, while no
significant correlation was observed with MCHC.

Keywords: Erythrocyte index, HbA, thalassemia.
}
}