?url_ver=Z39.88-2004&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Adc&rft.title=EFEKTIVITAS+EKSTRAK+ETANOL+DAUN+KELOR+(Moringa+oleifera)+TERHADAP+DAYA+HAMBAT+PERTUMBUHAN+BAKTERI+Propionibacterium+acnes&rft.creator=Azqiya+Putri%2C+Amourisva&rft.subject=610+Ilmu+kedokteran%2C+ilmu+pengobatan+dan+ilmu+kesehatan&rft.description=ntroduction%3A+Propionibacterium+acnes+is+a+bacteria+that+involved+in+pathogenesis%0D%0Aof+Acne+vulgaris.+An+alternative+antibiotics+from+natural+sources+is+needed%2C+one+of%0D%0Awhich+is+the+moringa+plant.+Moringa+leaf+extract+contains+active+compounds+such%0D%0Aas+flavonoids%2C+tannins%2C+alkaloids%2C+saponins%2C+terpenoids%2C+and+phenols+as+antibacterial%0D%0Aagents.%0D%0AMethods%3A+A+laboratory+experimental+design+was+used.+Moringa+leaves+were%0D%0Aseparated+from+the+stems+and+extracted+using+maceration+method+with+96%25+ethanol%0D%0Aand+divided+into+three+concentration+levels+(2.5%25%2C+5%25%2C+and+10%25).Clindamycin%0D%0Aphosphate+1.2%25+topical+solution+used+as+the+positive+control.+Antibacterial+activity%0D%0Awas+tested+using+disc+diffusion+method+on+BAP+inoculated+with+Propionibacterium%0D%0Aacnes.Data+were+analyzed+using+non-parametric+Kruskal-Wallis+test%2C+followed+by%0D%0APost+Hoc+LSD+analysis+to+determine+which+treatment+groups+showed+significant%0D%0Adifferences+after+an+overall+significant+difference+was+found.%0D%0AResults%3A+Bivariate+analysis+using+Kruskal-Wallis+method+showed+significant%0D%0Adifferences+among+all+treatment+groups.+Post+Hoc+LSD+analysis+revealed+significant%0D%0Adifferences+between+the+positive+control+group+and+the+96%25+ethanol+moringa+leaf%0D%0Aextract+groups+at+concentrations+of+2.5%25%2C+5%25%2C+and+10%25+in+inhibiting+the+growth%0D%0Aof+Propionibacterium+acnes%2C+with+a+p-value+of+0.001+(p+%3C+0.05)+and+an+average%0D%0Ainhibition+zone+of+0.00+mm.%0D%0AConclusion%3A+There+is+a+significant+difference+between+the+positive+control+group%0D%0Aand+the+treatment+groups+with+96%25+ethanol+moringa+leaf+extract+at+concentrations%0D%0Aof+2.5%25%2C+5%25%2C+and+10%25+against+Propionibacterium+acnes.%0D%0AKeywords%3A+Moringa+plant%2C+Propionibacterium+acnes%0D%0A%0D%0A%0D%0A%0D%0APendahuluan%3A+Propionibacterium+acnes+adalah+bakteri+yang+berperan+dalam%0D%0Apatogenesis+Acne+vulgaris.Diperlukan+alternatif+antibiotik+dari+bahan+alam+yang%0D%0Abermanfaat+sebagai+pengganti+antibiotik+resisten%2C+salah+satunya+tanaman%0D%0Akelor.Ekstrak+daun+kelor+mengandung+senyawa+aktif+yaitu+flavonoid%2C+tannin%2C%0D%0Aalkaloid%2C+sponin%2C+terpenoid+dan+fenol+sebagai+antibakteri.%0D%0AMetode%3A+Desian+eksperimental+laboratorik.Daun+kelor+dipisah+dari+tangkai+dan%0D%0Adiekstraksi+dengan+metode+maserasi+etanol+96%25%2C+bagi+menjadi+3+tingkatan%0D%0Akonsentrasi+(2%2C5%25%2C+5%25%2C+dan+10%25)%2C+klindamisin+fosfat+1%2C2%25+Topical+Solution+sebagai%0D%0Akontrol+positif.Uji+aktivitas+antibakteri+dengan+metode+disk+cakram+pada+media%0D%0ABAP+yang+diinokulasikan+bakteri+Propionibacterium+acnes.Data+dianalisis+dengan%0D%0Auji+non-parametrik+Kruskal-Wallis+dilanjut+uji+Post+Hoc+LSD+untuk+melihat%0D%0Akelompok+perlakuan+mana+yang+berbeda+setelah+ditemukan+perbedaan+signifikan%0D%0Asecara+keseluruhan.%0D%0AHasil%3A+Hasil+analisis+bivariat+metode+Kruskal-Wallis+menunjukkan+perbedaan%0D%0Asignifikan+antar+setiap+kelompok+perlakuan.Uji+Post+Hoc+LSD+menunjukkan%0D%0Aperbedaan+signifikan+pada+kelompok+kontrol+positif+dengan+ekstrak+etanol+96%25%0D%0Adaun+kelor+konsentrasi+2%2C5%25%2C+5%25%2C+dan+10%25+pada+pertumbuhan+bakteri%0D%0APropionibacterium+acnes+dengan+p-value+sebesar+0%2C001+(p+%3C+0%2C05)+dengan+rerata%0D%0Azona+hambat+0%2C00+mm.%0D%0AKesimpulan%3A+Terdapat+perbedaan+signifikan+antara+kelompok+perlakuan+kontrol%0D%0Apositif+dengan+kelompok+perlakuan+ekstrak+etanol+96%25+daun+kelor+dengan%0D%0Akonsentrasi+2%2C5%25%2C+5%25%2C+dan+10%25+terhadap+baketeri+Propionibacterium+acnes%0D%0AKata+Kunci%3A+Tanaman+Kelor%2C+Propionibacterium+acnes&rft.publisher=Kedokteran&rft.date=2024-11-29&rft.type=Skripsi&rft.type=NonPeerReviewed&rft.format=text&rft.identifier=http%3A%2F%2Fdigilib.unila.ac.id%2F81405%2F1%2F1.%2520ABSTRAK.pdf&rft.format=text&rft.identifier=http%3A%2F%2Fdigilib.unila.ac.id%2F81405%2F2%2F2.%2520SKRIPSI%2520FULL.pdf&rft.format=text&rft.identifier=http%3A%2F%2Fdigilib.unila.ac.id%2F81405%2F3%2F3.%2520SKRIPSI%2520TANPA%2520PEMBAHASAN.pdf&rft.identifier=++Azqiya+Putri%2C+Amourisva++(2024)+EFEKTIVITAS+EKSTRAK+ETANOL+DAUN+KELOR+(Moringa+oleifera)+TERHADAP+DAYA+HAMBAT+PERTUMBUHAN+BAKTERI+Propionibacterium+acnes.++Kedokteran%2C+Universitas+Lampung.++++(Submitted)++&rft.relation=http%3A%2F%2Fdigilib.unila.ac.id%2F81405%2F