creators_name: FARHRY , ALVINI RAHMANIA
creators_id: 2018011055
type: other
datestamp: 2025-01-24 14:28:26
lastmod: 2025-01-24 14:28:26
metadata_visibility: show
title: COMPARISON OF INHIBITORY EFFECTS OF PROBIOTIC
STREPTOCOCCUS THERMOPHILUS, CLINDAMYCIN, AND
ERYTHROMYCIN ON THE GROWTH OF CUTIBACTERIUM ACNES

BACTERIA: IN VITRO STUDY
ispublished: pub
subjects: 610
full_text_status: restricted
abstract: Background: Acne vulgaris is an inflammatory condition in the skin mostly
found in adolescents to adults. One factor that causes this condition is the
disproportion of normal flora in the skin due to colonization by Cutibacterium
acnes. This study aims to evaluate the comparison of in vitro inhibitory effects of
probiotic Streptococcus thermophilus, clindamycin, and erythromycin on the
growth of Cutibacterium acnes.
Methods: This study is a laboratory experimental study to compare the inhibition
zones produced by probiotic Streptococcus thermophilus, clindamycin, and
erythromycin using well diffusion method.
Results: There was a significant difference in the mean diameters of inhibition
zone of probiotic Streptococcus thermophilus, clindamycin, and erythromycin
(p=0). Erythromycin produced the largest inhibition zone against Cutibacterium
acnes with an average diameter of 31,72±2,68 mm. Furthermore, clindamycin
produced the second largest inhibition zone after erythromycin with an average
diameter of 30,22±1,90 mm. The smallest inhibition zone was produced by
probiotic Streptococcus thermophilus with an average diameter of 15.56±0.58 mm.
Conclusion: Erythromycin produced the largest inhibition zone against in vitro
growth of Cutibacterium acnes compared to the inhibition zones produced by
clindamycin and probiotic Streptococcus thermophilus.
Keywords: Cutibacterium acnes, inhibition zone, probiotic, Streptococcus
thermophilus

ABSTRAK

PERBANDINGAN DAYA HAMBAT PROBIOTIK STREPTOCOCCUS
THERMOPHILUS, KLINDAMISIN, DAN ERITROMISIN TERHADAP
PERTUMBUHAN BAKTERI CUTIBACTERIUM ACNES: STUDI IN

VITRO

Oleh

FARHRY ALVINI RAHMANIA

Latar Belakang: Akne vulgaris merupakan suatu kondisi inflamasi pada kulit
yang banyak ditemukan pada remaja hingga dewasa. Salah satu faktor penyebab
terjadinya kondisi ini ialah ketidakseimbangan flora normal pada kulit akibat
kolonisasi oleh Cutibacterium acnes. Penelitian ini bertujuan untuk melihat
perbandingan daya hambat probiotik Streptococcus thermophilus, klindamisin,
dan eritromisin terhadap pertumbuhan Cutibacterium acnes secara in vitro.
Metode: Penelitian ini merupakan penelitian eksperimental laboratorium untuk
membandingkan zona hambat probiotik Streptococcus thermophilus, klindamisin,
dan eritromisin menggunakan metode difusi sumuran.
Hasil: Hasil penelitian ini menunjukkan ada perbedaan pada rerata zona hambat
probiotik Streptococcus thermophilus, klindamisin, dan eritromisin (p=0).
Eritromisin menghasilkan zona hambat terbesar terhadap Cutibacterium acnes
dengan rerata diameter sebesar 31,72±2,68 mm. Selanjutnya, klindamisin
menghasilkan zona hambat terbesar kedua setelah eritromisin dengan rerata
diameter sebesar 30,22±1,90 mm. Zona hambat terkecil dihasilkan oleh probiotik
Streptococcus thermophilus dengan rerata diameter sebesar 15,56±0,58 mm.
Simpulan: Eritromisin menghasilkan zona hambat terbesar terhadap pertumbuhan
Cutibacterium acnes secara in vitro dibandingkan dengan zona hambat yang
dihasilkan oleh klindamisin dan probiotik Streptococcus thermophilus.
Kata kunci: Cutibacterium acnes, probiotik, Streptococcus thermophilus, zona
hambat
date: 2024-04-18
date_type: published
publisher: FAKULTAS KEDOKTERAN
place_of_pub: UNIVERSITAS LAMPUNG
citation:   FARHRY , ALVINI RAHMANIA  (2024) COMPARISON OF INHIBITORY EFFECTS OF PROBIOTIC STREPTOCOCCUS THERMOPHILUS, CLINDAMYCIN, AND ERYTHROMYCIN ON THE GROWTH OF CUTIBACTERIUM ACNES BACTERIA: IN VITRO STUDY.  FAKULTAS KEDOKTERAN, UNIVERSITAS LAMPUNG.     
document_url: http://digilib.unila.ac.id/81528/1/open%5B1%5D
document_url: http://digilib.unila.ac.id/81528/2/open%5B1%5D
document_url: http://digilib.unila.ac.id/81528/3/open%5B1%5D