?url_ver=Z39.88-2004&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Adc&rft.title=ISOLASI+DAN+KARAKTERISASI+SENYAWA+BIOAKTIF+FUNGI+SEDIMEN%0D%0AMANGROVE+SERTA+UJI+BIOAKTIVITAS+TERHADAP+Malassezia+globosa&rft.creator=Carlos%2C++Daniel&rft.subject=540+Kimia+dan+ilmu+yang+berhubungan&rft.description=Fungi+sedimen+mangrove+memiliki+metabolit+sekunder+dengan+aktivitas+farmakologis%0D%0Ayang+signifikan+dengan+jalur+biosintesis+senyawa+yang+unik%2C+serta+sebagian+besar+masih%0D%0Abelum+dieksplorasi.+Penelitian+ini+bertujuan+untuk+memperoleh+senyawa+antifungi%0D%0Aterhadap+Malassezia+globosa+dari+ekstrak+fungi+yang+berasal+dari+sedimen+mangrove%0D%0Adi+daerah+Pesawaran%2C+Lampung.+Isolat+fungi+yang+diperoleh+(21RSM1%2C+21RSM2%2C+dan%0D%0A21RSM5)+dikultivasi+pada+media+padat+diantaranya+media+kulit+udang%2C+kedelai+dan%0D%0Aberas+selama+14+hari.+Hasil+kultur+dimaserasi+menggunakan+pelarut+etil+asetat+(EtOAc).%0D%0AEkstrak+kasar+diskrining+aktivitas+antifungi+terhadap+M.+globosa+dengan+metode+difusi%0D%0Aagar.+Dalam+penelitian+ini%2C+ekstrak+fungi+21RSM2-MKU+paling+unggul+sebagai%0D%0Aantifungi+dengan+zona+hambat+18mm+terhadap+M.+globosa+pada+konsentrasi+10+mg%2FmL.%0D%0ASampel+21RSM2-MKU+difraksinasi+melalui+kromatografi+kolom+dan+setiap+fraksi+yang%0D%0Adihasilkan+selanjutnya+dimonitoring+kemurniannya+serta+diskrining+aktivitas%0D%0Aantifunginya+menggunakan+KLT+dan+metode+difusi+agar.+Fraksi+paling+aktif+dari%0D%0A21RSM2-MKU+memiliki+daya+hambat+antifungi+sebesar+14+mm+terhadap+M.+globosa%0D%0Apada+konsentrasi+10+mg%2FmL+yang+dikategorikan+dalam+golongan+kuat+sebagai+antifungi%2C%0D%0Afraksi+aktif+21RSM2-MKUF6F4+dikarakterisasi+menggunakan+LC-MS%2FMS+dan+FTIR.%0D%0ASampel+21RSM2-MKUF6F4+diketahui+mempunyai+senyawa+golongan+peptida+dengan%0D%0Astruktur+dasar+imidazol%2C+senyawa+imidazol+diketahui+sebagai+sumber+antifungi+yang%0D%0Amenghambat+pertumbuhan+M.+globosa.+Informasi+awal+ini+menjadi+penting+untuk%0D%0Apengembangan+lebih+lanjut+dalam+pencarian+senyawa+bioaktif+yang+berasal+dari+fungi%0D%0Asedimen+mangrove.%0D%0A%0D%0AKata+kunci+%3A+Sedimen+mangrove%2C+fungi%2C+fermentasi+padat%2C+antifungi%2C+M.+globosa%0D%0AMangrove+sediment+fungi+have+secondary+metabolites+with+significant%0D%0Apharmacological+activities+and+unique+compound+biosynthesis+pathways%2C+many+of%0D%0Awhich+are+still+unexplored.+This+research+aims+to+obtain+antifungal+compounds+against%0D%0AMalassezia+globosa+from+fungi+extracts+sourced+from+mangrove+sediments+in%0D%0APesawaran%2C+Lampung.+The+obtained+fungal+isolates+(21RSM1%2C+21RSM2%2C+and%0D%0A21RSM5)+were+cultured+on+solid+media+including+shrimp+shell%2C+soybean%2C+and+rice+media%0D%0Afor+14+days.+The+culture+results+were+macerated+using+ethyl+acetate+(EtOAc)+solvent.%0D%0AThe+crude+extracts+were+screened+for+antifungal+activity+against+M.+globosa+using+the%0D%0Aagar+diffusion+method.+In+this+study%2C+the+extract+from+fungus+21RSM-MKU+was+found%0D%0Ato+be+the+most+effective+antifungal+agent%2C+with+an+inhibition+zone+of+18+mm+against+M.%0D%0Aglobosa+at+10+mg%2FmL+concentration.+Sample+21RSM-MKU+was+fractionated+through%0D%0Acolumn+chromatography%2C+and+each+resulting+fraction+was+further+monitored+for+purity%0D%0Aand+screened+for+antifungal+activity+using+TLC+and+the+agar+diffusion+method.+The%0D%0Amost+active+fraction+of+21RSM2-MKU+showed+an+antifungal+inhibition+of+14+mm%0D%0Aagainst+M.+globosa+at+a+concentration+of+10+mg%2FmL%2C+categorized+as+a+strong+antifungal.%0D%0AThe+active+fraction+21RSM2-MKUF6F4+was+characterized+using+LC-MS%2FMS+and%0D%0AFTIR.+Sample+21RSM2-MKUF6F4+was+identified+to+contain+peptide+compounds+with%0D%0Aan+imidazole+basic+structure.+Imidazole+compounds+are+known+antifungals+that+inhibit%0D%0Athe+growth+of+M.+globosa.+This+preliminary+information+is+important+for+further%0D%0Adevelopment+in+the+search+for+bioactive+compounds+from+mangrove+sediment+fungi.%0D%0A%0D%0AKeywords+%3A+Mangrove+sediment%2C+fungi%2C+Solid+state+fermentation+(SSF)%2C+antifungi%2C%0D%0AM.globosa&rft.publisher=MATEMATIKA+DAN+ILMU+PENGETAHUAN+ALAM+&rft.date=2024-07-29&rft.type=Skripsi&rft.type=NonPeerReviewed&rft.format=text&rft.identifier=http%3A%2F%2Fdigilib.unila.ac.id%2F81755%2F1%2FCarlos%2520Daniel_2017011055_File%2520Abstrak%2520-%2520Carlos%2520Daniel.pdf&rft.format=text&rft.identifier=http%3A%2F%2Fdigilib.unila.ac.id%2F81755%2F2%2FCarlos%2520Daniel_2017011055_Skripsi%2520Full%2520-%2520Carlos%2520Daniel.pdf&rft.format=text&rft.identifier=http%3A%2F%2Fdigilib.unila.ac.id%2F81755%2F3%2FCarlos%2520Daniel_2017011055_Skripsi%2520Tanpa%2520Bab%2520Pembahasan%2520-%2520Carlos%2520Daniel.pdf&rft.identifier=++Carlos%2C+Daniel++(2024)+ISOLASI+DAN+KARAKTERISASI+SENYAWA+BIOAKTIF+FUNGI+SEDIMEN+MANGROVE+SERTA+UJI+BIOAKTIVITAS+TERHADAP+Malassezia+globosa.++MATEMATIKA+DAN+ILMU+PENGETAHUAN+ALAM+%2C+UNIVERSITAS+LAMPUNG+.+++++&rft.relation=http%3A%2F%2Fdigilib.unila.ac.id%2F81755%2F