?url_ver=Z39.88-2004&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Adc&rft.title=PENGARUH+PEMBERIAN+EKSTRAK+ETANOL+BUAH+PARE+(Momordica%0D%0Acharantia+L.)+TERHADAP+PENURUNAN+KADAR+GULA+DARAH+DAN%0D%0AGEJALA+TOKSISITAS+PADA+MENCIT+(Mus+musculus+L.)&rft.creator=Khatarina+%2C+Septi+Amelia+Putri&rft.subject=500+ilmu+pengetahuan+alam+dan+matematika&rft.subject=570+Biologi&rft.description=Hiperglikemia+adalah+terjadinya+peningkatan+kadar+gula+darah+di+atas+normal.%0D%0AHiperglikemia+disebabkan+oleh+gula+yang+menumpuk+dalam+darah+dan+tidak%0D%0Amampu+masuk+ke+dalam+sel%2C+gangguan+hormon+insulin%2C+dan+faktor+keturunan.%0D%0AKondisi+hiperglikemia+dapat+menyebabkan+kerusakan+jaringan+dan+gangguan%0D%0Afungsi+organ+seperti+hati%2C+ginjal%2C+dan+jantung.+Beberapa+kajian+menunjukkan+buah%0D%0AMomordica.+charantia+mengandung+senyawa+yang+dapat+merangsang+perbaikan%0D%0Asel-sel+beta%2C+sehingga+dapat+meningkatkan+produksi+insulin+dan+toleransi+glukosa.%0D%0APenelitian+ini+bertujuan+untuk+menguji+efektivitas+ekstrak+etanol+buah+M.%0D%0Acharantia+terhadap+penurunan+kadar+gula+darah+dan+uji+efek+subletal+pada+mencit%0D%0Ajantan+yang+diinduksi+aloksan.+Parameter+yang+digunakan+meliputi+rerata+berat%0D%0Abadan%2C+rerata+kadar+gula+darah%2C+berat+relatif+organ%2C+dan+pengamatan+organ%0D%0Amakroskopis.+Metode+penelitian+yang+digunakan+adalah+Rancangan+Acak%0D%0ALengkap+(RAL)+yang+melibatkan+6+kelompok+perlakuan+hewan+uji+dengan+5%0D%0Aulangan%2C+yaitu+K(-)%3A+kontrol+negatif+(tanpa+induksi+aloksan+dan+bahan+uji)%2C+K(%2B)%3A%0D%0Akontrol+positif+(diinduksi+aloksan)%2C+P1%3A+kelompok+yang+diinduksi+aloksan+dan%0D%0Adiberi+ekstrak+M.+charantia+5+mg%2FkgBB%2C+P2%3A+kelompok+yang+diinduksi+aloksan%0D%0Adan+diberi+ekstrak+M.+charantia+50+mg%2FkgBB%2C+P3%3A+kelompok+yang+diinduksi%0D%0Aaloksan+dan+diberi+ekstrak+M.+charantia+300+mg%2FkgBB%2C+P4%3A+kelompok+yang%0D%0Adiinduksi+aloksan+dan+diberi+ekstrak+M.+charantia+2000+mg%2FkgBB.+Data+dianalisis%0D%0Adengan+uji+Levene%2C+One-Way+Anova%2C+dan+dilanjutkan+uji+BNT+pada+taraf+nyata+5%25.%0D%0AHasil+analisis+statistik+One-Way+Anova+dilanjutkan+dengan+uji+BNT+pada+taraf%0D%0Anyata+5%25+menunjukkan+pemberian+ekstrak+etanol+buah+pare+mampu+menurunkan%0D%0Akadar+gula+darah+mencit+jantan+yang+diinduksi+aloksan%2C+kelompok+P4+menjadi%0D%0Akelompok+yang+efektif+dengan+penurunan+kadar+glukosa+darah+yang+cukup+tinggi%0D%0A(129%2C5+mg%2FdL)+dan+berbeda+nyata+dengan+kelompok+K(-)%2C+K(%2B)%2C+P1%2C+P2%2C+dan+P3.%0D%0APengamatan+rerata+organ+dan+makroskopis+tidak+menunjukkan+gejala+kerusakan%0D%0Aakibat+sifat+toksik+sehingga+ekstrak+etanol+buah+pare+aman+untuk+digunakan.%0D%0AKata+kunci%3A+Aloksan%2C+Hiperglikemia%2C+Momordica+charantia.%0D%0A%0D%0A%0D%0AHyperglycemia+refers+to+an+increase+in+blood+sugar+levels+above+the+normal+range.%0D%0AVarious+factors%2C+including+the+accumulation+of+sugar+in+the+blood%2C+insulin+hormone%0D%0Adisorders%2C+and+heredity+can+cause+this+condition.+Hyperglycemia+can+lead+to+tissue%0D%0Adamage+and+impair+the+functioning+of+organs+such+as+the+liver%2C+kidneys%2C+and+heart.%0D%0AResearch+has+indicated+that+Momordica+charantia+fruit+contains+compounds+that%0D%0Acan+stimulate+the+repair+of+beta+cells%2C+which+in+turn+improves+insulin+production%0D%0Aand+glucose+tolerance.+A+study+was+conducted+on+alloxan-induced+male+mice+to%0D%0Atest+the+effectiveness+of+the+ethanol+extract+of+M.charantia+fruit+as+a+means+to%0D%0Adecrease+blood+sugar+levels+and+evaluate+its+safety.+Parameters+used+include+mean%0D%0Abody+weight%2C+mean+blood+sugar+level%2C+sublethal+effect%2C+relative+organ+weight%2C+and%0D%0Amacroscopic+observations.+The+research+method+was+a+completely+randomized%0D%0Adesign+involving+6+treatment+groups+of+test+animals+with+5+replicates.+These%0D%0Agroups+included+K(-)%3A+(negative+control+without+alloxan+induction+and+test%0D%0Amaterials)%2C+K(%2B)%3A+(positive+control+induced+with+alloxan)%2C+P1%3A+(group+was+induced%0D%0Aby+alloxan+and+was+given+5+mg%2FkgBW+M.charantia+extract)%2C+P2%3A+(group+was%0D%0Ainduced+by+alloxan+and+was+given+50+mg%2FkgBW+M.charantia+extract)%2C+P3%3A+(group%0D%0Awas+induced+by+alloxan+and+was+given+300+mg%2FkgBW+M.charantia+extract)%2C+and%0D%0AP4%3A+(group+was+induced+by+alloxan+and+was+given+2000+mg%2FkgBW+M.charantia%0D%0Aextract).+The+data+will+be+analyzed+with+Levene+test%2C+One-Way+ANOVA%2C+and+then%0D%0Acontinued+by+LSD+test+at+5%25.+One-Way+Anova+followed+by+LSD+test+at+5%25+level%0D%0Aof+significance+was+applied+to+analyze+data+and+indicated+that+bitter+melon+ethanol%0D%0Aextract+was+able+to+reduce+blood+sugar+levels+in+male+mice+induced+by+alloxan%2C%0D%0AThe+P4+group+became+the+best+group+with+a+fairly+high+reduction+in+blood+glucose%0D%0Alevels+(129.5+mg%2FdL)+and+significantly+different+from+the+K(-)%2C+K(%2B)%2C+P1%2C+P2%2C+and%0D%0AP3+groups.+Observations+of+organ+and+macroscopic+mean+did+not+show+symptoms%0D%0Aand+toxic+properties+so+that+bitter+melon+ethanol+extract+is+safe+to+use.%0D%0AKey+words%3A+Alloxan%2C+Hyperglycemia%2C+Momordica+charantia&rft.publisher=FAKULTAS+MATEMATIKA+DAN+ILMU+PENGETAHUAN+ALAM&rft.date=2024-08-09&rft.type=Skripsi&rft.type=NonPeerReviewed&rft.format=text&rft.identifier=http%3A%2F%2Fdigilib.unila.ac.id%2F82322%2F1%2FABSTRAK%2520-%2520Khatarina%2520Putri.pdf&rft.format=text&rft.identifier=http%3A%2F%2Fdigilib.unila.ac.id%2F82322%2F2%2FFull%2520Skripsi%2520Tanpa%2520Lampiran%2520Isi%2520-%2520Khatarina%2520Putri.pdf&rft.format=text&rft.identifier=http%3A%2F%2Fdigilib.unila.ac.id%2F82322%2F3%2FFull%2520Skripsi%2520Tanpa%2520Pembahasan%2520-%2520Khatarina%2520Putri.pdf&rft.identifier=++Khatarina+%2C+Septi+Amelia+Putri++(2024)+PENGARUH+PEMBERIAN+EKSTRAK+ETANOL+BUAH+PARE+(Momordica+charantia+L.)+TERHADAP+PENURUNAN+KADAR+GULA+DARAH+DAN+GEJALA+TOKSISITAS+PADA+MENCIT+(Mus+musculus+L.).++FAKULTAS+MATEMATIKA+DAN+ILMU+PENGETAHUAN+ALAM%2C+UNIVERSITAS+LAMPUNG.+++++&rft.relation=http%3A%2F%2Fdigilib.unila.ac.id%2F82322%2F