?url_ver=Z39.88-2004&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Adc&rft.title=ANALISIS+EFEK+PEMBERIAN+EKSTRAK+ETANOL+DAUN+KAYU%0D%0APUTIH+(Melaleuca+cajuputi)+TERHADAP+HISTOPATOLOGI+HEPAR%0D%0ATIKUS+PUTIH+(Rattus+norvegicus)+GALUR+SPRAGUE%0D%0ADAWLEY+YANG+DIINDUKSI+ASAP+ROKOK&rft.creator=Herlingga+Nirwana%2C+HR&rft.subject=600+Teknologi+(ilmu+terapan)&rft.subject=610+Ilmu+kedokteran%2C+ilmu+pengobatan+dan+ilmu+kesehatan&rft.description=Background%3A+Melaleuca+cajuputi+is+a+monoterpene+compound+known+for+its+anti-%0D%0Ainflammatory+efficacy.+The+primary+constituents+of+Melaleuca+cajuputi+are+1%2C8-%0D%0A%0D%0Acineole%2C+%CE%B1-terpineol%2C+%CE%B2-caryophyllene%2C+and+flavonoids.+The+1%2C8-cineole+has+the%0D%0Apotential+to+reduce+pro-inflammatory+cytokines.+while+%CE%B2-caryophyllene+shows%0D%0Asignificant+antihyaluronidase+activity%2C+which+plays+a+crucial+role+in+regulating%0D%0Awound+healing+by+reducing+the+inflammatory+response.%0D%0AMethods%3A+this+study+used+a+post-test+only+control+group+design+on+35+Sprague%0D%0ADawley+rats+that+was+divided+into+5+groups+namely+KN%2C+K%2B%2C+P1%2C+P2+and+P3.+All%0D%0Agroups+were+exposed+to+10+cigarettes+of+smoke+per+day%2C+except+the+normal+group%0D%0A(KN).+The+K%2B+group+did+not+receive+eucalyptus+leaf+extract%2C+while+groups+P1+and%0D%0AP2+were+given+eucalyptus+leaf+extract+at+50+mg%2FkgBW+and+100+mg%2FkgBW%2C%0D%0Arespectively.+The+P3+group+was+given+ibuprofen+at+1.6+mg%2F0%2C2kgBW.+The+rats+were%0D%0Aterminated%2C+and+their+liver+were+taken+for+HE+examination.+The+score+used+for+HE%0D%0Aexamination+was+the+Mordue+score.%0D%0AResults%3A+The+average+Mordue+scores+for+group+KN%2C+K%2B%2C+P1%2C+P2+and+P3+were+1%2C0%3B%0D%0A2%2C80%3B+1%2C60%3B+1%2C60%3B+and+0%2C40%2C+respectively.+The+Kruskal-Wallis+test+showed+p%3D0%2C011.%0D%0APost+Hoc+Mann-Whitney+test+showed+p%26lt%3B0%2C05+for+the+data+between+K%2B+group+and%0D%0AP1%2C+P2%2C+and+P3+groups.%0D%0AConclusion%3A+Melaleuca+cajuputi+at+doses+of+50+mg%2FkgBW%2C+100+mg%2FkgBW+and%0D%0Aibuprofen+at+a+dose+of+1.6+mg%2F0%2C2kgBW+has+effect+on+the+liver+histopathology%0D%0Apatterns+of+the+liver%E2%80%99s+rats+exposed+to+cigarette+smoke%0D%0AKeywords%3A+Cigarette+smoke%2C+Ibuprofen%2C+Liver%2C+Melaleuca+cajuputi%0D%0A%0D%0ALatar+Belakang%3A+Melaleuca+cajuputi+adalah+tumbuhan+yang+merupakan+senyawa%0D%0Amonoterpen+yang+memiliki+efek+anti-inflamasi.+Kandungan+utama+Melaleuca%0D%0Acajuputi+adalah+1%2C8-cineole%2C+%CE%B1-terpineol%2C+%CE%B2-caryophyllene%2C+dan+flavonoid.+1%2C8-%0D%0A%0D%0Acineole+memiliki+potensi+untuk+mengurangi+sitokin+pro-inflamasi%2C+sementara+%CE%B2-%0D%0Acaryophyllene+memiliki+aktivitas+antihialuronidase+tinggi+yang+berperan+penting%0D%0A%0D%0Adalam+regulasi+penyembuhan+luka+dengan+mengurangi+respon+inflamasi.%0D%0AMetode%3A+penelitian+ini+menggunakan+desain+post-test+only+control+group+pada+35%0D%0Atikus+Sprague+Dawley+yang+dibagi+menjadi+5+kelompok%3A+KN%2C+K%2B%2C+P1%2C+P2%2C+dan+P3.%0D%0ASemua+kelompok+terpapar+10+batang+asap+rokok+per+hari%2C+kecuali+kelompok+normal%0D%0A(KN).+Kelompok+K%2B+tidak+menerima+ekstrak+daun+kayu+putih%2C+sedangkan+kelompok%0D%0AP1+dan+P2+masing-masing+diberikan+ekstrak+daun+kayu+putih+dengan+dosis+50%0D%0Amg%2FkgBB+dan+100+mg%2FkgBB%2C+sementara+kelompok+P3+diberikan+ibuprofen+dengan%0D%0Adosis+1%2C6+mg%2F200+gBB.+Tikus+kemudian+diterminasi+dan+hepar+mereka+diambil%0D%0Auntuk+pemeriksaan+HE.+Skor+yang+digunakan+untuk+pemeriksaan+HE+adalah+skor%0D%0AMordue.%0D%0AHasil%3A+rerata+skor+Mordue+untuk+kelompok+KN%2C+K%2B%2C+P1%2C+P2%2C+dan+P3+masing-+masing%0D%0Aadalah+1%2C0%3B+2%2C80%3B+1%2C60%3B+1%2C60%3B+dan+0%2C40.+Uji+Kruskal-Wallis+menunjukkan+p%3D0%2C011.%0D%0AUji+Post+Hoc+Mann-Whitney+menunjukkan+p%26lt%3B0%2C05+untuk+data+antara+kelompok%0D%0AK%2B+dengan+kelompok+P1%2C+P2%2C+dan+P3.%0D%0ASimpulan%3A+ekstrak+daun+kayu+putih+(Melaleuca+cajuputi)+dengan+dosis+50+mg%2FkgBB%0D%0Adan+100+mg%2FkgBB%2C+serta+ibuprofen+dengan+dosis+1%2C6+mg%2F0%2C2kgBB%2C+memiliki+efek%0D%0Apada+pola+histopatologi+hati+tikus+yang+terpapar+asap+rokok.%0D%0AKata+Kunci%3A+Hepar%2C+Ibuprofen%2C+Melaleuca+cajuputi%2C+Rokok&rft.publisher=FAKULTAS+KEDOKTERAN&rft.date=2024-07-16&rft.type=Skripsi&rft.type=NonPeerReviewed&rft.format=text&rft.identifier=http%3A%2F%2Fdigilib.unila.ac.id%2F83000%2F1%2FABSTRAK%2520-%2520Herlingga%2520Nirwana%2520HR.pdf&rft.format=text&rft.identifier=http%3A%2F%2Fdigilib.unila.ac.id%2F83000%2F2%2FSKRIPSI%2520FULL%2520-%2520Herlingga%2520Nirwana%2520HR.pdf&rft.format=text&rft.identifier=http%3A%2F%2Fdigilib.unila.ac.id%2F83000%2F3%2FSKRIPSI%2520FULL%2520TANPA%2520BAB%2520PEMBAHASAN%2520-%2520Herlingga%2520Nirwana%2520HR.pdf&rft.identifier=++Herlingga+Nirwana%2C+HR++(2024)+ANALISIS+EFEK+PEMBERIAN+EKSTRAK+ETANOL+DAUN+KAYU+PUTIH+(Melaleuca+cajuputi)+TERHADAP+HISTOPATOLOGI+HEPAR+TIKUS+PUTIH+(Rattus+norvegicus)+GALUR+SPRAGUE+DAWLEY+YANG+DIINDUKSI+ASAP+ROKOK.++FAKULTAS+KEDOKTERAN%2C+UNIVERSITAS+LAMPUNG.+++++&rft.relation=http%3A%2F%2Fdigilib.unila.ac.id%2F83000%2F