?url_ver=Z39.88-2004&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Adc&rft.title=FORMULASI+DAN+UJI+AKTIVITAS+ANTIBAKTERI%0D%0ANANOSPRAY+EKSTRAK+ETANOL+DAUN+JERUK+PURUT%0D%0A(Citrus+hystrix+DC)+TERHADAP+BAKTERI+Staphylococcus%0D%0A%0D%0Aaureus+PENYEBAB+JERAWAT&rft.creator=SEKAR+RAHMASARI+RATNA%2C+CIPTANINGRUM&rft.subject=600+Teknologi+(ilmu+terapan)&rft.subject=610+Ilmu+kedokteran%2C+ilmu+pengobatan+dan+ilmu+kesehatan&rft.description=Background%3A+Acne+vulgaris+or+acne+is+a+skin+disease+caused+by+infection+with+Staphylococcus%0D%0Aaureus+bacteria+with+the+number+of+sufferers+increasing+every+year.+Kaffir+lime+leaves+have+the%0D%0Apotential+to+be+an+antibacterial+compound.+The+formulation+of+the+Self-Nanoemulsifying+Drug%0D%0ADelivery+System+(SNEDDS)+was+chosen+to+improve+the+solubility+and+stability+of+the%0D%0Apreparation.+The+formulation+was+developed+into+a+nanospray+preparation+as+a+cocmetic%0D%0Apreparation+to+improve+the+drug+delivery+system+with+even+distribution+and+practical%0D%0Aapplication.%0D%0AMethods%3A+This+study+used+an+experimental+method+to+determine+the+optimum+concentration%0D%0Aformulated+into+SNEDDS+and+nanospray+as+an+antibacterial+Staphylococcus+aureus+and+a%0D%0Acharacteristic+test+was+carried+out+on+SNEDDS+and+nanospray.%0D%0AResult%3A+The+results+showed+that+10%25+kaffir+lime+leaf+ethanol+extract+was+optimally+delipidized%0D%0Ain+inhibiting+Staphylococcus+aureus+with+nanospray+inhibition+containing+SNEDDS+of+27%2C837%0D%0Amm.+the+result+of+the+nanoemulsion+characteristics+in+SNEDDS+has+a+particle+size+of+295%2C2+nm%3B%0D%0Athe+polydispersity+index+value+was+0%2C338%3B+the+size+of+the+spherical+globule%3B+zeta+potential+value%0D%0A-11%2C13+mV%3B+and+97%2C484%25+transmittance+percentage.+In+the+physical+characteristics+of%0D%0Ananospray%2C+the+preparation+meets+the+stability+after+a+freeze+thaw+test.%0D%0AConclusion%3A+Ethanol+extract+of+kaffir+lime+leaf+with+a+concentration+of+10%25+delipidized+can+be%0D%0Aformulated+into+SNEDDS+and+nanospray+with+very+strong+inhibition+against+Staphylococcus%0D%0Aaureus%3B+SNEDDS+and+nanospray+meet+the+criteria+of+the+preparation+characteristics.%0D%0AKeyword%3A+antibacterial%2C+kaffir+lime+leaf%2C+nanospray%2C+SNEDDS%2C+Staphylococcus+aureus.%0D%0A%0D%0ALatar+Belakang%3A+Acne+vulgaris+atau+jerawat+merupakan+penyakit+kulit+yang+disebabkan+oleh%0D%0Ainfeksi+bakteri+Staphylococcus+aureus+dengan+jumlah+penderitanya+meningkat+di+tiap+tahunnya.%0D%0ADaun+jeruk+purut+berpotensi+sebagai+senyawa+antibakteri.+Formulasi+Self-Nanoemulsifying%0D%0ADrug+Delivery+System+(SNEDDS)+dipilih+untuk+meningkatkan+kelarutan+dan+kestabilan%0D%0Asediaan.+Formulasi+dikembangkan+menjadi+sediaan+nanospray+sebagai+sediaan+kosmetika%0D%0Auntuk+meningkatkan+sistem+penghantaran+obat+dengan+daya+sebar+yang+merata+dan%0D%0Apengaplikasiannya+yang+praktis.%0D%0AMetode%3A+Penelitian+ini+menggunakan+metode+eksperimental+untuk+mengetahui+konsentrasi%0D%0Aoptimum+yang+diformulasikan+menjadi+SNEDDS+dan+nanospray+sebagai+antibakteri%0D%0AStaphylococcus+aureus+serta+dilakukan+uji+karakteristik+pada+SNEDDS+dan+nanospray.%0D%0AHasil%3A+Hasil+penelitian+menunjukkan+bahwa+ekstrak+etanol+daun+jeruk+purut+10%25+terdelipidasi%0D%0Aoptimal+dalam+menghambat+Staphylococcus+aureus+dengan+daya+hambat+nanospray+yang%0D%0Amengandung+SNEDDS+sebesar+27%2C837+mm.+Hasil+dari+karakteristik+nanoemulsi+pada+SNEDDS%0D%0Amemiliki+ukuran+partikel+sebesar+295%2C2+nm%3B+nilai+indeks+polidispersitas+0%2C338%3B+ukuran+globul%0D%0Asferis%3B+nilai+potensial+zeta+-11%2C13+mV%3B+dan+persen+transmitan+97%2C484%25.+Pada+karakteristik+fisik%0D%0Ananospray%2C+sediaan+memenuhi+stabilitas+setelah+dilakukan+uji+freeze+thaw.%0D%0AKesimpulan%3A+Ekstrak+etanol+daun+jeruk+purut+konsentrasi+10%25+terdelipidasi+dapat%0D%0Adiformulasikan+menjadi+SNEDDS+dan+nanospray+dengan+daya+hambat+sangat+kuat+terhadap%0D%0AStaphylococcus+aureus%3B+SNEDDS+dan+nanospray+memenuhi+kriteria+karakteristik+sediaan.%0D%0AKata+Kunci%3A+antibakteri%2C+daun+jeruk+purut%2C+nanospray%2C+SNEDDS%2C+Staphylococcus+aureus.&rft.publisher=FAKULTAS+KEDOKTERAN&rft.date=2024-07-18&rft.type=Skripsi&rft.type=NonPeerReviewed&rft.format=text&rft.identifier=http%3A%2F%2Fdigilib.unila.ac.id%2F83027%2F1%2FABSTRAK%2520SEKAR%2520-%2520Sekar%2520Rahmasari%2520RC.pdf&rft.format=text&rft.identifier=http%3A%2F%2Fdigilib.unila.ac.id%2F83027%2F2%2FSKRIPSI%2520DIGILIB%2520FULL%2520PEMBAHASAN%25201-5%2520FIX%2520%2528SEKAR%2529%2520-%2520Sekar%2520Rahmasari%2520RC.pdf&rft.format=text&rft.identifier=http%3A%2F%2Fdigilib.unila.ac.id%2F83027%2F3%2FFIX%2520FILE%2520SKRIPSI%2520TANPA%2520PEMBAHASAN%2520%2528SEKAR%2529%2520-%2520Sekar%2520Rahmasari%2520RC.pdf&rft.identifier=++SEKAR+RAHMASARI+RATNA%2C+CIPTANINGRUM++(2024)+FORMULASI+DAN+UJI+AKTIVITAS+ANTIBAKTERI+NANOSPRAY+EKSTRAK+ETANOL+DAUN+JERUK+PURUT+(Citrus+hystrix+DC)+TERHADAP+BAKTERI+Staphylococcus+aureus+PENYEBAB+JERAWAT.++FAKULTAS+KEDOKTERAN%2C+UNIVERSITAS+LAMPUNG.+++++&rft.relation=http%3A%2F%2Fdigilib.unila.ac.id%2F83027%2F