?url_ver=Z39.88-2004&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Adc&rft.title=PENGARUH+PEMBERIAN+EKSTRAK+ETANOL+LADA+HITAM+%0D%0A(Piper+nigrum+L.)+TERHADAP+FUNGSI+EREKSI+DAN+JUMLAH+SEL%0D%0ALEYDIG+TIKUS+PUTIH+JANTAN+MODEL+HIPERGLIKEMIA%0D%0A&rft.creator=FAZA+%2C+HASBULLAH++&rft.subject=610+Ilmu+kedokteran%2C+ilmu+pengobatan+dan+ilmu+kesehatan&rft.description=Background%3A+Black+pepper+contains+piperine%2C+which+can+inhibit+apoptosis+of%0D%0ALeydig+cells+in+individuals+with+diabetes+mellitus%2C+potentially+preventing+erectile%0D%0Adysfunction.+This+study+aimed+to+determine+the+effect+of+administering+ethanol%0D%0Aextract+of+black+pepper+on+erectile+function+and+the+number+of+Leydig+cells+in+male%0D%0Awhite+rats+modeled+with+hyperglycemia.+%0D%0AMethod%3A+An+experimental+research+post-test-only+control+group+design+was+applied%0D%0Ato+30+male+white+rats.+The+rats+were+divided+into+five+groups%3A+the+zero+control+(K0)%2C%0D%0Anegative+control+(K-)%2C+positive+control+(K%2B)+with+Sildenafil%2C+and+two+treatment%0D%0Agroups+of+hyperglycemic+rats+receiving+black+pepper+ethanol+extract+at+doses+of%0D%0A122.5+mg%2FkgBW+(P1)+and+245+mg%2FkgBW+(P2).+The+black+pepper+ethanol+extract%0D%0Awas+administered+for+8+days.+Erectile+function+was+observed+by+calculating+the+Total%0D%0APenile+Reflex+(TPR)+score%2C+and+the+number+of+Leydig+cells+was+assessed+after+the%0D%0Atermination+of+all+sample+rats.+%0D%0AResults%3A+Univariate+analysis+showed+that+groups+P1+and+P2+had+higher+mean+TPR%0D%0Ascores+(P1%3A+9.33%C2%B11.03+%26+P2%3A+8.00%C2%B10.89)+and+Leydig+cell+counts+(P1%3A+59.33%C2%B14.08+%26%0D%0AP2%3A+50.67%C2%B12.73)+compared+to+the+K(-)+group+(TPR%3A+6.00%C2%B11.26+%26+Leydig+cells%3A%0D%0A30.50%C2%B13.86).+Bivariate+analysis+using+One-Way+ANOVA+indicated+that+the+mean%0D%0ATPR+scores+and+Leydig+cell+counts+in+groups+P1+and+P2+differed+significantly%0D%0A(p%3C0.05)+from+the+K(-)+group.+%0D%0AConclusion%3A+This+study+indicates+that+ethanol+extract+of+black+pepper%2C+especially+at%0D%0Aa+dose+of+122.5+mg%2FkgBW%2C+has+the+potential+to+increase+the+number+of+Leydig+cells%0D%0Aand+improve+erectile+function+in+hyperglycemic+male+white+rats%2C+suggesting+its%0D%0Apotential+as+a+standardized+herbal+medicine+for+erectile+dysfunction+in+patients+with%0D%0Adiabetes+mellitus.%0D%0A%0D%0AKeywords%3A+black+pepper%2C+diabetes+mellitus%2C+erectile+dysfunction%2C+leydig+cells.%0D%0A%0D%0ALatar+Belakang%3A+Lada+hitam+memiliki+kandungnnya+piperin+yang+dapat%0D%0Amenghambat+proses+apoptosis+sel+Leydig+pada+penderita+diabetes+melitus+yang%0D%0Adapat+menyebabkan+disfungsi+ereksi.+Penelitian+ini+bertujuan+untuk+mengetahui%0D%0Apengaruh+pemberian+ekstrak+etanol+lada+hitam+pada+fungsi+ereksi+dan+jumlah+sel%0D%0ALeydig+tikus+putih+jantan+model+hiperglikemia.+%0D%0AMetode%3A+Desain+penelitian+eksperimental+dengan+grup+kontrol+post-test-only%0D%0Aditerapkan+pada+30+tikus+jantan+Rattus+norvegicus.+Tikus+dibagi+ke+dalam+5%0D%0Akelompok%3A+Kontrol+nol%2FK0%2C+kontrol+negatif%2FK(-)%2C+kontrol+positif%2FK(%2B)+dengan%0D%0ASildenafil+serta+kelompok+perlakuan+yakni+tikus+model+hiperglikemia+yang%0D%0Adiberikan+ekstrak+etanol+lada+hitam+dosis+122%2C5+mg%2FkgBB+(P1)+dan+245+mg%2FkgBB%0D%0A(P2).+Pemberian+ekstrak+etanol+lada+hitam+dilakukan+selama+8+hari.+Pengamatan%0D%0Afungsi+ereksi+dilakukan+dengan+penghitungan+nilai+Total+Penile+Reflex+(TPR)+dan%0D%0Ajumlah+sel+Leydig+dihitung+setelah+seluruh+tikus+sampel+diterminasi.+%0D%0AHasil%3A+Analisis+univariat+menunjukkan+bahwa+kelompok+P1+dan+P2+memiliki+rerata%0D%0Anilai+TPR(P1%3B+9%2C33%C2%B11%2C03+%26+P2%3B+8%2C00%C2%B10%2C89)+dan+jumlah+sel+Leydig+(P1%3B+59%2C33%C2%B14%2C08%0D%0A%26+P2%3B+50%2C67%C2%B12%2C73)+lebih+tinggi+dibandingkan+dengan+kelompok+K(-)+(TPR%3B%0D%0A6%2C00%C2%B11%2C26+%26+sel+Leydig%3B+30%2C50%C2%B13%2C86).+Analisis+bivariat+dengan+One+Way+ANOVA%0D%0Akelompok+P1+dan+P2+memiliki+rerata+nilai+TPR+dan+jumlah+sel+Leydig+memiliki%0D%0Aperbedaan+yang+signifikan+(p%3C0%2C05)+dengan+kelompok+K(-).+%0D%0ASimpulan%3A+Penelitian+ini+menujukkan+bahwa+ekstrak+etanol+lada+hitam%2C+terutama%0D%0Apada+dosis+122%2C5+mg%2FkgBB%2C+berpotensi+meningkatkan+jumlah+sel+Leydig+dan+fungsi%0D%0Apada+tikus+putih+jantan+model+hiperglikemia%2C+sehingga+memiliki+potensi+sebagai%0D%0Asalah+satu+bahan+obat+herbal+terstandar+untuk+disfungsi+ereksi+pada+pasien+diabetes%0D%0Amelitus.+%0D%0A%0D%0AKata+Kunci%3A+diabetes+melitus%2C+disfungsi+ereksi%2C+lada+hitam%2C+sel+leydig.%0D%0A&rft.publisher=FAKULTAS+KEDOKTERAN&rft.date=2025-01-14&rft.type=Skripsi&rft.type=NonPeerReviewed&rft.format=text&rft.identifier=http%3A%2F%2Fdigilib.unila.ac.id%2F83122%2F1%2FABSTRAK.pdf&rft.format=text&rft.identifier=http%3A%2F%2Fdigilib.unila.ac.id%2F83122%2F2%2FSKRIPSI%2520FULL%2520TANPA%2520LAMPIRAN.pdf&rft.format=text&rft.identifier=http%3A%2F%2Fdigilib.unila.ac.id%2F83122%2F3%2FSKRIPSI%2520FULL%2520TANPA%2520PEMBAHASANA.pdf&rft.identifier=++FAZA+%2C+HASBULLAH+++(2025)+PENGARUH+PEMBERIAN+EKSTRAK+ETANOL+LADA+HITAM+(Piper+nigrum+L.)+TERHADAP+FUNGSI+EREKSI+DAN+JUMLAH+SEL+LEYDIG+TIKUS+PUTIH+JANTAN+MODEL+HIPERGLIKEMIA.++FAKULTAS+KEDOKTERAN%2C+UNIVERSITAS+LAMPUNG.+++++&rft.relation=http%3A%2F%2Fdigilib.unila.ac.id%2F83122%2F