title: PENGARUH TEH DAUN JATI CINA (Cassia Angustifoia Vahl)  TERHADAP KADAR KOLESTEROL TOTAL MENCIT  (Mus Musculus) JANTAN GALUR DDY YANG  DIINDUKSI DIET TINGGI LEMAK
creator: M. ANDRIANSAH, -
subject: 610 Ilmu kedokteran, ilmu pengobatan dan ilmu kesehatan
description: Latar Belakang: Kadar kolesterol total merupakan salah penyebab kematian  tertinggi didunia yang prevalensinya meningkat setiap tahunnya. Kadar kolesterol  total ditandai dengan konsumsi lemak dan peningkatan kadar kolesterol didalam  darah, peningkatan ini disebut hiperkolesterolemia. Daun jati cina memiliki  berbagai kandungan yang berpotensi sebagai antikolesterol, antioksidan, memiliki  efek laktasif, serta antidiabetes. Penelitian ini dilakukan untuk mengetahui  pengaruh teh daun jati cina (cassia angustiofoia vahl) terhadap kadar kolesterol  total pada mencit (mus musculus) jantan galur ddy yang diinduksi diet tinggi  lemak.  Metode: Penelitian eksperimental dengan post-test control group design. Sampel  penelitian sebanyak 25 ekor mencit dibagi ke dalam 5 kelompok yaitu, KN (pakan  standar + air), K- (kuning telur 0,1ml), P1 (kuning telur 0,1ml + teh daun jati cina  dosis 0,06 g/kgBB), P2 (kuning telur 0,1ml + teh daun jati cina dosis 0,13  g/kgBB), dan P3 (kuning telur 0,1ml + teh daun jati cina dosis 0,19 g/kgBB).  Kadar kolesterol total dinilai dengan Easy Touch (GCU).  Hasil: Rerata kadar kolesterol total setiap kelompok adalah KN = 103,4mg/dL, K-  = 165,2 mg/dL, P1= 113,8 mg/dL, P2= 109 mg/dL dan P3= 104,2 mg/dL. Uji One  Way ANOVA didapatkan nilai p=0,000 (p<0,05).  Simpulan: Terdapat penurunan kadar kolesterol terbesar dibandingkan kelompok  negatif pada mencit galur ddy setelah diberi perlakuan. Terdapat pengaruh  pemberian teh daun jati cina (cassia angustifoia vahl) terhadap kadar kolesterol  total mencit (mus musculus) jantan galur ddy yang induksi diet tinggi lemak.  Didapatkan dosis efektif (ED50) yaitu 7042,25g/kgbb untuk teh daun jati cina  (Cassia Angustifolia Vahl) terhadap kadar kolesterol total pada mencit (Mus  musculus) jantan galur ddy yang diinduksi diet tinggi lemak.  Kata Kunci: daun jati cina, kolesterol total, lemak, hati, cassia angustifoia vahl,  mus musculus    ABSTRACT    EFFECT OF CHINESE JATI LEAF TEA (Cassia Angustifoia Vahl) ON  TOTAL CHOLESTEROL RATE OF MENCITES (Mus Musculus)  MALE DDY GALURS INDUCED BY A HIGH-FAT DIET    By  M. ANDRIANSAH    Background: Total cholesterol levels are one of the highest causes of death in the  world, with prevalence increasing every year. Total cholesterol levels are  characterized by fat consumption and increased cholesterol levels in the blood,  this increase is called hypercholesterolemia. Chinese teak leaves have various  contents that have the potential as anti-inflammatory, antioxidant, have a lactasive  effect, and antidiabetic. This study was conducted to determine the effect of  Chinese teak leaf tea (cassia angustiofoia vahl) on total cholesterol levels in male  ddy mice (mus musculus) induced by a high-fat diet.  Methods: Experimental research with post-test control group design. The  research sample was 25 mice divided into 5 groups, namely, KN (standard feed +  water), K- (egg yolk 0,1 ml), P1 (egg yolk 0,1ml + Chinese teak leaf tea dose  0,06g/kgBB), P2 (egg yolk + Chinese teak leaf tea dose 0,13g/kgBB), and P3 (egg  yolk 0,1ml + Chinese teak leaf tea dose 0,19g/kgBB). Total cholesterol levels  were assessed with Easy Touch (GCU).  Results: The mean total cholesterol levels of each group were KN = 103,4 mg/dL,  K- = 165,2 mg/dL, P1 = 113,8 mg/dL, P2 = 109 mg/dL and P3 = 104.2 mg/dL.  One Way ANOVA test obtained p=0.000 (p<0.05).  Conclusion: There is a decrease in cholesterol levels compared to the  negative group in ddy mice after being treated. There is an effect of giving  Chinese teak leaf tea (cassia angustifoia vahl) on total cholesterol levels in male  ddy mice (mus musculus) induced by a high-fat diet. The effective dose (ED50)  was obtained, namely 7042.25g/kgbb for Chinese teak leaf tea (cassia angustifolia  vahl) on total cholesterol levels in male mice (mus musculus) ddy strains induced  by a high-fat diet.  Keywords: Chinese teak leaf, total cholesterol, fat, liver, cassia angustifoia vahl,  musculus mus.
publisher: FAKULTAS KEDOKTERAN
date: 2024-06-19
type: Skripsi
type: NonPeerReviewed
format: text
identifier: http://digilib.unila.ac.id/83677/1/ABSTRAK%20AJA%20-%20M.%20Andri%20Ansah.pdf
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identifier: http://digilib.unila.ac.id/83677/2/FULL%20SKRIPSI%20-%20M.%20Andri%20Ansah.pdf
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identifier: http://digilib.unila.ac.id/83677/3/SKRIPSI%20FULL%20TANPA%20BAB%20PEMBAHASAN%20-%20M.%20Andri%20Ansah.pdf
identifier:   M. ANDRIANSAH, -  (2024) PENGARUH TEH DAUN JATI CINA (Cassia Angustifoia Vahl) TERHADAP KADAR KOLESTEROL TOTAL MENCIT (Mus Musculus) JANTAN GALUR DDY YANG DIINDUKSI DIET TINGGI LEMAK.  FAKULTAS KEDOKTERAN, UNIVERSITAS LAMPUNG.     
relation: http://digilib.unila.ac.id/83677/