%0 Generic
%A AZIZAH , NUR RAHMAH
%C UNIVERSITAS LAMPUNG
%D 2024
%F eprints:83822
%I FAKULTAS KEDOKTERAN
%T HUBUNGAN KEBERADAAN Mycobacterium tuberculosis (MTB) DAN  RESISTENSI RIFAMPICIN TES GENEXPERT DENGAN LUAS LESI  RADIOGRAFI TORAKS PADA PASIEN TUBERKULOSIS PARU  DEWASA DI RSUD DR. H. ABDUL MOELOEK LAMPUNG
%U http://digilib.unila.ac.id/83822/
%X Latar Belakang: Indonesia memiliki sangat banyak jumlah kasus TB tidak  terlaporkan serta kasus TB multidrug-resistant dan resisten Rifampicin di tahun  2021. Tes GeneXpert tidak hanya mempunyai kemampuan mendeteksi resistensi  Rifampicin, tetapi juga meningkatkan jumlah pasien TB terkonfirmasi  bakteriologis di antara kasus pemeriksaan sputum Basil Tahan Asam (BTA) negatif  karena memiliki sensitivitas yang lebih tinggi dibandingkan pemeriksaan sputum  BTA. Penelitian sebelumnya menemukan bahwa radiografi toraks normal tidak  selalu berarti hasil pemeriksaan bakteriologis negatif. Penelitian ini bertujuan untuk  mengetahui apakah jumlah Mycobacterium tuberculosis (MTB) dan resistensi  bakteri tersebut terhadap Rifampicin memengaruhi derajat lesi paru atau, dengan  kata lain, menyebabkan kerusakan berat.  Metode: Penelitian analitik observasional dengan pendekatan cross sectional.  Sampel merupakan 110 rekam medis pasien TB paru dewasa yang diperoleh    menggunakan teknik total sampling. Data dianalisis menggunakan uji Kruskal-  Wallis dan Chi-Square.    Hasil: Mayoritas pasien resisten Rifampicin maupun sensitif Rifampicin, baik  dengan hasil “MTB detected high”, “MTB detected medium”, ataupun “MTB  detected low” menunjukkan gambaran lesi far advanced. Berdasarkan hasil uji  Kruskal-Wallis, tidak terdapat hubungan antara keberadaan MTB dengan luas lesi  pada 29 pasien resisten Rifampicin (p-value = 0,338). Hasil yang serupa ditemukan  pada hasil uji Chi-Square, yaitu tidak ada hubungan antara resistensi Rifampicin  dengan luas lesi pada 110 pasien (p-value = 0,561). Akan tetapi, terdapat hubungan    antara keberadaan MTB dengan luas lesi pada 81 pasien sensitif Rifampicin (p-  value = 0,009).    Kesimpulan: Penelitian ini menunjukkan bahwa, meskipun tidak terdapat  hubungan signifikan secara statistik antara keberadaan MTB pada pasien resisten  Rifampicin dan resistensi Rifampicin itu sendiri dengan luas lesi paru, baik MTB  yang resisten Rifampicin maupun sensitif Rifampicin memiliki potensi yang setara  dalam menimbulkan lesi paru berat. Di sisi lain, terdapat hubungan bermakna  secara statistik antara keberadaan MTB pada pasien sensitif Rifampicin dengan luas  lesi paru. Hal ini menunjukkan bahwa semakin banyak jumlah MTB, semakin berat  lesi paru pada pasien sensitif Rifampicin.  Kata Kunci: GeneXpert, luas lesi, Mycobacterium tuberculosis, radiografi toraks,  resistensi Rifampicin, tuberkulosis paru.  THE CORRELATION BETWEEN GENEXPERT TESTS PRESENCE OF  Mycobacterium tuberculosis (MTB) ALONG WITH RIFAMPICIN  RESISTANCE AND THE EXTENT OF THORACIC RADIOGRAPHY  LESIONS IN ADULT PULMONARY TUBERCULOSIS PATIENTS  AT RSUD DR. H. ABDUL MOELOEK LAMPUNG    By    AZIZAH NUR RAHMAH    Background: Indonesia was abundant with unreported tuberculosis (TB) cases as  well as cases of multidrug-resistant/Rifampicin-resistant TB in 2021. GeneXpert  test holds the ability to not only detect Rifampicin resistance, but also increase the  number of bacteriologically confirmed TB patients among negative acid-fast bacilli  (AFB) smear cases since its sensitivity surpasses that of AFB smear. Earlier finding  presented that a normal thoracic radiography doesn’t necessarily mean a negative  bacteriological examination result. This study aimed to investigate whether the  amount of Mycobacterium tuberculosis (MTB) and the resistance of said bacteria  to Rifampicin affect the degree of lung lesion or, in other words, create an advanced  damage.  Method: Observational analytical research with a cross sectional approach. The  samples were 110 medical records of adult pulmonary TB (PTB) patients obtained  using total sampling technique. The data were analysed using the Kruskal-Wallis  and Chi-Square tests.  Results: Both the majority of Rifampicin-resistant and Rifampicin-sensitive  patients, either with “MTB detected high”, “MTB detected medium”, or “MTB    detected low” results, presented with far advanced lesions. Based on the Kruskal-  Wallis test outcome, there was no correlation between the presence of MTB and the    extent of lesions in 29 Rifampicin-resistant patients (p-value = 0.338). Similar result  were found in the Chi-Square test outcome, in which there was also no correlation  between Rifampicin resistance and the extent of lesions in 110 patients (p-value =  0.561). However, there was a correlation between the presence of MTB and the  extent of lesions in 81 Rifampicin-sensitive patients (p-value = 0.009).  Conclusion: This study shows that, although there is no significant statistical  correlation between the presences of MTB in Rifampicin-resistant patients along  with the Rifampicin resistances itself and the extent of lung lesions, both  Rifampicin-resistant MTB and Rifampicin-sensitive MTB have equal potentials in  causing advanced lung lesions. On the other hand, there is a significant statistical  correlation between the presences of MTB in Rifampicin-sensitive patients and the  extent of lung lesions. This concludes that the higher the amounts of MTB, the more  serious the lung lesions in patients with sensitivity to Rifampicin.  Keywords: Extent of lesion, GeneXpert, Mycobacterium tuberculosis, pulmonary  tuberculosis, Rifampicin resistance, thoracic radiography.