?url_ver=Z39.88-2004&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Adc&rft.title=UJI+TOKSISITAS+EKSTRAK+KULIT+JERUK+NIPIS+(Citrus+aurantifolia)%0D%0ADENGAN+METODE+BRINE+SHRIMP+LETHALITY+TEST+(BSLT)+UNTUK%0D%0A%0D%0ADETEKSI+AKTIVITAS+ANTI+KANKER&rft.creator=INDAH+%2C+KHAIRUNNISA+%09&rft.subject=570+Biologi&rft.description=Kanker+termasuk+salah+satu+dari+berbagai+masalah+utama+yang+terjadi+pada%0D%0Amasyarakat+Indonesia+dan+juga+dunia.+Kurangnya+kesadaran+masyarakat+untuk%0D%0Adeteksi+dini+menyebabkan+terjadinya+keterlambatan+diagnosis.+Indonesia+dikenal%0D%0Asebagai+negara+agraris+yang+memiliki+berbagai+jenis+tanaman%2C+termasuk+tanaman%0D%0Aobat.+Salah+satu+tanaman+obat+yang+banyak+dijumpai+yaitu+jeruk+nipis+(C.%0D%0Aaurantifolia).+Pada+ekstrak+kulit+jeruk+nipis%2C+terdapat+minyak+atsiri+yang+tersusun%0D%0A%0D%0Adari+D-Limonene+(38%2C94%25)%2C+%CE%B2-pinen+(26%2C66%25)%2C+%CE%B1-terpineol+(8%2C29%25)%2C+dan+terpinen-%0D%0A4-ol+(4%2C32%25).+Senyawa-senyawa+tersebut+diketahui+memiliki+efek+yang+kuat+sebagai%0D%0A%0D%0Aanti+kanker.+Penelitian+ini+bertujuan+untuk+menguji+tingkat+toksisitas+ekstrak+kulit%0D%0Ajeruk+nipis+(C.+aurantifolia)+dengan+menggunakan+metode+Brine+Shrimp+Lethality%0D%0ATest+(BSLT)+untuk+mendeteksi+aktivitas+anti+kanker.+Pada+penelitian+ini+digunakan%0D%0ARancangan+Acak+Lengkap+(RAL)+dengan+5+perlakuan+dan+5+kali+pengulangan%2C+yaitu%0D%0A0+ppm%2C+125+ppm%2C+250+ppm%2C+500+ppm%2C+dan+1000+ppm.+Metode+penelitian+yang%0D%0Adigunakan+yaitu+uji+fitokimia%2C+analisis+FTIR+(Fourier-Transform+Infrared%0D%0ASpectroscopy)%2C+dan+uji+BSLT.+Hasil+dari+uji+BSLT+ditentukan+berdasarkan+Lethal%0D%0AConcentration+(LC50)+dari+jumlah+Artemia+salina+yang+mati+akibat+pengaruh%0D%0Apemberian+ekstrak+tanaman.+Setelah+itu%2C+nilai+probit+dianalisis+dengan%0D%0Amenggunakan+SPSS+untuk+mendapatkan+nilai+LC50.+Ekstrak+kulit+jeruk+nipis+(C.%0D%0Aaurantifolia)+memiliki+nilai+LC50+331%2C533+ppm+termasuk+kategori+toksik+dan%0D%0Aberpotensi+sebagai+agen+anti+kanker.+Berdasarkan+pada+uji+fitokimia+dan+FTIR+kulit%0D%0Ajeruk+nipis+(C.+aurantifolia)+mengandung+senyawa+alkaloid%2C+flavonoid%2C+dan+tanin%0D%0Ayang+diketahui+memiliki+sifat+antioksidan+dan+dapat+mengganggu+keseimbangan%0D%0AReactive+Oxygen+Species+(ROS)+sehingga+dapat+memicu+apoptosis+sel+kanker.%0D%0AKata+kunci%3A+anti+kanker%2C+kulit+jeruk+nipis+(C.+aurantifolia)%2C+Artemia+salina%2C+Brine%0D%0AShrimp+Lethality+Test+(BSLT)%2C+FTIR%2C+fitokimia%0D%0A%0D%0ACancer+is+one+of+the+major+problems+affecting+the+people+of+Indonesia+and+the%0D%0Aworld.+Lack+of+public+awareness+for+early+detection+causes+late+diagnosis.%0D%0AIndonesia+known+as+an+agricultural+country+that+has+various+types+of+plants%2C%0D%0Aincluding+medicinal+plants.+One+of+the+many+medicinal+plants+found+is+lime+(C.%0D%0Aaurantifolia).+In+lime+peel+extract%2C+there+are+essential+oils+composed+of+D-Limonene%0D%0A(38.94%25)%2C+%CE%B2-pinene+(26.66%25)%2C+%CE%B1-terpineol+(8.29%25)%2C+and+terpinen-4-ol+(4.32%25).%0D%0AThese+compounds+known+to+have+strong+effects+as+anti-cancer.+This+study+aims+to%0D%0Atest+the+toxicity+of+lime+peel+extract+(C.+aurantifolia)+using+the+Brine+Shrimp%0D%0ALethality+Test+(BSLT)+method+to+detect+anti-cancer+activity.+This+study+used+a%0D%0ACompletely+Randomized+Design+(CRD)+with+5+treatments+and+5+repetitions%2C+which%0D%0Aare+0+ppm%2C+125+ppm%2C+250+ppm%2C+500+ppm%2C+and+1000+ppm.+The+research+methods+used%0D%0Awere+phytochemical+test%2C+FTIR+(Fourier-Transform+Infrared+Spectroscopy)%0D%0Aanalysis%2C+and+BSLT.+The+results+of+the+BSLT+were+determined+based+on+the+Lethal%0D%0AConcentration+(LC50)+of+the+number+of+Artemia+salina+that+died+because+of+the+effect%0D%0Aof+the+plant+extract.+After+that%2C+the+probit+value+was+analyzed+using+SPSS+to+obtain%0D%0Athe+LC50+value.+Lime+peel+extract+(C.+aurantifolia)+has+a+LC50+value+of+331%2C533+ppm%0D%0Ais+considered+toxic+and+has+potential+as+an+anti-cancer+agent.+Based+on%0D%0Aphytochemical+and+FTIR+tests%2C+lime+peel+(C.+aurantifolia)+contains+alkaloid%2C%0D%0Aflavonoid%2C+and+tannin+compounds+which+are+known+to+have+antioxidant+properties%0D%0Aand+can+disrupt+the+balance+of+Reactive+Oxygen+Species+(ROS)+which+can+trigger%0D%0Aapoptosis+of+cancer+cells.%0D%0AKeywords%3A+anti-cancer%2C+C.+aurantifolia%2C+Artemia+salina%2C+Brine+Shrimp+Lethality+Test%0D%0A(BSLT)%2C+FTIR%2C+phytochemistry&rft.publisher=FAKULTAS+MATEMATIKA+DAN+ILMU+PENGETAHUAN+ALAM&rft.date=2024-05-16&rft.type=Skripsi&rft.type=NonPeerReviewed&rft.format=text&rft.identifier=http%3A%2F%2Fdigilib.unila.ac.id%2F84102%2F1%2FABSTRAK%2520-%2520Indah%2520Khairunnisa.pdf&rft.format=text&rft.identifier=http%3A%2F%2Fdigilib.unila.ac.id%2F84102%2F2%2FSKRIPSI%2520FULL%2520-%2520Indah%2520Khairunnisa.pdf&rft.format=text&rft.identifier=http%3A%2F%2Fdigilib.unila.ac.id%2F84102%2F3%2FSKRIPSI%2520TANPA%2520BAB%2520PEMBAHASAN%2520-%2520Indah%2520Khairunnisa.pdf&rft.identifier=++INDAH+%2C+KHAIRUNNISA+++(2024)+UJI+TOKSISITAS+EKSTRAK+KULIT+JERUK+NIPIS+(Citrus+aurantifolia)+DENGAN+METODE+BRINE+SHRIMP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