?url_ver=Z39.88-2004&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Adc&rft.title=KLASIFIKASI+GEN+ESENSIAL+PADA+SEKUENS+PROTEIN%0D%0ADROSOPHILA+MELANOGASTER+MENGGUNAKAN+METODE%0D%0ABIDIRECTIONAL+GATED+RECURRENT+UNIT+(BiGRU)&rft.creator=YULIA+%2C+DWI+PUTRI&rft.subject=000+Ilmu+komputer%2C+informasi+dan+pekerjaan+umum&rft.subject=005+Pemrograman+komputer%2C+program+dan+data&rft.subject=500+ilmu+pengetahuan+alam+dan+matematika&rft.description=Gen+esensial+berperan+penting+dalam+kelangsungan+hidup+organisme%2C+dan%0D%0Aidentifikasinya+memiliki+aplikasi+luas+dalam+biologi+sintetis+dan+medis.+Namun%2C%0D%0Ateknik+eksperimental+sering+kali+mahal+dan+rumit%2C+sehingga+metode+komputasional%0D%0Aberbasis+pembelajaran+mesin+menjadi+alternatif+yang+lebih+efisien.+Metode+yang%0D%0Adigunakan+adalah+Bidirectional+Gated+Recurrent+Unit+(BiGRU)+dengan%0D%0Amenggunakan+Drosophila+melanogaster+sebagai+organisme+model.+Tujuan+dari%0D%0Apenelitian+ini+adalah+untuk+mengevaluasi+kinerja+metode+Bidirectional+Gated%0D%0ARecurrent+Unit+(BiGRU)+dalam+sekuens+protein+pada+Drosophila+melanogaster.%0D%0ADataset+yang+digunakan+diperoleh+dari+penelitian+Beder%2C+et+al%2C+(2021)+dengan+2+jenis%0D%0Adataset+yaitu+Cellular+Essential+Gene+(CEG)+dan+Organismal+Essential+Gene%0D%0A(OEG).+Ada+dua+skema+arsitektur+model+dan+dua+skenario+pembagian+data%2C+yaitu%0D%0A80%25+training+20%25+validation+dan+90%25+training+10%25+validation.+Pada+dataset+CEG%0D%0Amemiliki+distribusi+kelas+yang+tidak+seimbang+sehingga+dilakukan+proses+Random%0D%0AUndersampling+(RUS).+Hasil+kinerja+yang+paling+baik+pada+dataset+OEG%0D%0Adidapatkan+pada+skenario+pembagian+data+80%25+training+20%25+validation+dengan%0D%0Anilai+yang+didapat+adalah+83+%25+sensitivitas%2C+79+%25+spesifisitas%2C+80%25+nilai+ROC-AUC%0D%0Adan+85%25+nilai+PR-AUC.+Hasil+yang+paling+baik+pada+dataset+CEG+diperoleh+dari%0D%0Apembagian+data+90%25+training+10%25+validation+dengan+nilai+yang+didapat+untuk%0D%0Asensitivitas+adalah+73%25%2C+spesifisitas+55%25%2C+nilai+ROC-AUC+64%25+dan+nilai+PR-AUC%0D%0A46%25.%0D%0AKata+Kunci%3A+BiGRU%2C+Drosophila+melanogaster%2C+Gen+Esensial%2C+Sekuens+Protein.%0D%0A%0D%0AEssential+genes+play+a+crucial+role+in+the+survival+of+organisms%2C+and+their%0D%0Aidentification+has+wide+applications+in+synthetic+biology+and+medicine.+However%2C%0D%0Aexperimental+techniques+are+often+expensive+and+complex%2C+making+computational%0D%0Amethods+based+on+machine+learning+a+more+efficient+alternative.+The+method+used%0D%0Ain+this+study+is+the+Bidirectional+Gated+Recurrent+Unit+(BiGRU)%2C+with+Drosophila%0D%0Amelanogaster+as+the+model+organism.+The+aim+of+this+research+is+to+evaluate+the%0D%0Aperformance+of+the+BiGRU+method+in+protein+sequences+of+Drosophila%0D%0Amelanogaster.+The+dataset+used+was+obtained+from+the+study+by+Beder+et+al.+(2021)%0D%0Aand+consists+of+two+types+of+datasets%3A+Cellular+Essential+Gene+(CEG)+and%0D%0AOrganismal+Essential+Gene+(OEG).+There+are+two+model+architecture+schemes+and%0D%0Atwo+data-splitting+scenarios%3A+80%25+training+and+20%25+validation%2C+and+90%25+training%0D%0Aand+10%25+validation.+The+CEG+dataset+has+an+imbalanced+class+distribution%2C+so%0D%0ARandom+Undersampling+(RUS)+was+applied.+The+best+performance+for+the+OEG%0D%0Adataset+was+achieved+with+the+80%25+training+and+20%25+validation+split%2C+yielding+83%25%0D%0Asensitivity%2C+79%25+specificity%2C+80%25+ROC-AUC%2C+and+85%25+PR-AUC.+The+best%0D%0Aperformance+for+the+CEG+dataset+was+obtained+with+the+90%25+training+and+10%25%0D%0Avalidation+split%2C+yielding+73%25+sensitivity%2C+55%25+specificity%2C+64%25+ROC-AUC%2C+and%0D%0A46%25+PR-AUC.%0D%0AKeywords%3A+BiGRU%2C+Drosophila+melanogaster%2C+Essential+Genes%2C+Protein+Sequence.%0D%0A&rft.publisher=FAKULTAS+MATEMATIKA+DAN+ILMU+PENGETAHUAN+ALAM&rft.date=2024-10-02&rft.type=Skripsi&rft.type=NonPeerReviewed&rft.format=text&rft.identifier=http%3A%2F%2Fdigilib.unila.ac.id%2F84494%2F1%2Fabstrak%2520-%2520Yulia%2520Dwi%2520Putri.pdf&rft.format=text&rft.identifier=http%3A%2F%2Fdigilib.unila.ac.id%2F84494%2F2%2FSKRIPSI%2520FULL%2520-%2520Yulia%2520Dwi%2520Putri.pdf&rft.format=text&rft.identifier=http%3A%2F%2Fdigilib.unila.ac.id%2F84494%2F3%2FSKRIPSI%2520tanpa%2520pembahasan%2520-%2520Yulia%2520Dwi%2520Putri.pdf&rft.identifier=++YULIA+%2C+DWI+PUTRI++(2024)+KLASIFIKASI+GEN+ESENSIAL+PADA+SEKUENS+PROTEIN+DROSOPHILA+MELANOGASTER+MENGGUNAKAN+METODE+BIDIRECTIONAL+GATED+RECURRENT+UNIT+(BiGRU).++FAKULTAS+MATEMATIKA+DAN+ILMU+PENGETAHUAN+ALAM%2C+UNIVERSITAS+LAMPUNG.+++++&rft.relation=http%3A%2F%2Fdigilib.unila.ac.id%2F84494%2F