?url_ver=Z39.88-2004&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Adc&rft.title=STUDI+ONE-HEALTH+DENGAN+PENDEKATAN+IN+SILICO+FIBRINOGEN-%0D%0ABINDING+PROTEIN+A+(FbsA)+BAKTERI+Streptococcus+agalactiae+ASAL+IKAN%0D%0A%0D%0ADAN+KASUS+KLINIS+MANUSIA&rft.creator=Rifaldi+Iqbal%2C+Yadiansyah&rft.subject=500+ilmu+pengetahuan+alam+dan+matematika&rft.subject=570+Biologi&rft.description=Di+Singapura+dan+Malaysia%2C+Streptococcus+Grup+B+(SGB)+dengan+sequence+type+(ST)+283+telah%0D%0Adilaporkan+dapat+menginfeksi+manusia+melalui+konsumsi+pangan+asal+hewan%2C+seperti+ikan%0D%0Amentah.+Studi+one-health+terkait+dengan+protein+faktor+virulensi+SGB+belum+dilakukan+secara%0D%0A%0D%0Aluas.+Kasus+SGB+ST283+mendorong+dilakukannya+studi+one-health+terhadap+fibrinogen-%0D%0Abinding+protein+A+(FbsA)+dari+SGB+asal+dari+ikan+dan+kasus+klinis+manusia.+Studi+one-health%0D%0A%0D%0Asecara+in+silico+dilakukan+untuk+menguji+kemiripan+profil+FbsA+SGB+yang+berasal+dari+dua%0D%0Aspesies+inang+yang+berbeda+dan+untuk+menyelidiki+profil+interaksi+FbsA+dengan+fibrinogen+(Fg)%0D%0Amanusia.+Dua+sampel+sekuen+asam+amino+FbsA+dari+kasus+klinis+ikan+dan+manusia+diperoleh%0D%0Adari+National+Center+of+Biotechnology+Information%2C+sementara+struktur+kristal+protein%0D%0Afibrinogen+manusia+diperoleh+dari+Protein+Data+Bank.+Penyejajaran+dua+sampel+sekuen+FbsA%0D%0Adari+inang+yang+berbeda+dilakukan+menggunakan+program+MUSCLE+untuk+menilai+kemiripan%0D%0Aprofil+protein.+Prediksi+struktur+tiga+dimensi+FbsA+SGB+dilakukan+menggunakan+ColabFold%0D%0Aversi+1.5.5.+Studi+penambatan+molekul+dengan+ClusPro+versi+2.0+dilakukan+untuk+melihat%0D%0Ainteraksi+antara+FbsA+SGB+dan+rantai+A%CE%B1%2C+B%CE%B2%2C+dan+%CE%B3+fibrinogen+manusia.+Hasil+menunjukkan%0D%0Akedua+sampel+sekuen+asam+amino+FbsA+menunjukkan+kemiripan+urutan+sebesar+100%25.%0D%0AInteraksi+menunjukkan+residu-residu+dalam+wilayah+berulang+FbsA+SGB+berinteraksi+dengan%0D%0Arantai+%CE%B1%2C+%CE%B2%2C+%CE%B3+rantai+Fg+manusia+pada+fragmen+D+Fg+dan+didominasi+oleh+kelompok+residu+kritis%2C%0D%0Aresidu+yang+dilaporkan+memainkan+peran+penting+dalam+Fg-binding.+Residu-residu+kritis+ini%0D%0Aterutama+terletak+di+wilayah+berulang+dari+ke-45+hingga+ke-60.+Interaksi+juga+terjadi+pada+situs%0D%0A%CE%B2119-129%2C+situs+pembelahan+protein+fibrinolitik+plasmin.+Temuan+ini+diduga+berkontribusi+pada%0D%0Apatogenesis+penyakit%2C+terutama+dalam+gejala+klinis+endokarditis+dan+septicemia%2C+dan+berpotensi%0D%0Asebagai+penyakit+zoonosis+berasal+dari+ikan.%0D%0AKata+Kunci%3A+One-health%2C+Zoonosis%2C+Streptococcus+Grup+B%2C+Fibrinogen-binding+protein+A%2C+In%0D%0ASilico%0D%0A%0D%0AIn+Singapore+and+Malaysia%2C+Group+B+Streptococcus+(GBS)+with+sequence+type+(ST)+283+has%0D%0Abeen+reported+to+infect+humans+through+the+consumption+of+animal-derived+food%2C+such+as+raw%0D%0Afish.+One-health+studies+related+to+the+virulence+factor+proteins+of+GBS+have+not+been%0D%0A%0D%0Aextensively+conducted.+Cases+of+GBS+ST283+prompted+a+one-health+study+of+the+fibrinogen-%0D%0Abinding+protein+A+(FbsA)+of+GBS+originating+from+fish+and+human+clinical+cases.+In+silico+one-%0D%0Ahealth+studies+were+conducted+to+examine+the+similarity+of+FbsA+GBS+profiles+originating+from%0D%0A%0D%0Atwo+different+host+species+and+to+investigate+the+interaction+profiles+of+FbsA+with+human%0D%0Afibrinogen+(Fg).+Two+samples+of+FbsA+amino+acid+sequences+from+fish+and+human+clinical%0D%0Acases+were+obtained+from+the+National+Center+of+Biotechnology+Information%2C+while+the+crystal%0D%0Astructure+of+human+fibrinogen+protein+was+obtained+from+the+Protein+Data+Bank.+Alignment+of%0D%0Athe+two+FbsA+sequence+samples+from+different+hosts+was+performed+using+the+MUSCLE%0D%0Aprogram+to+assess+protein+profile+similarity.+Three-dimensional+structure+prediction+of+fish%0D%0AFbsA+GBS+was+conducted+using+ColabFold+version+1.5.5.+Molecular+docking+investigation%0D%0Awith+ClusPro+version+2.0+was+performed+to+examine+the+interaction+between+FbsA+GBS+and%0D%0Athe+A%CE%B1%2C+B%CE%B2%2C+and+%CE%B3+chains+of+human+fibrinogen.+The+results+indicated+that+both+samples+of+FbsA%0D%0Aamino+acid+sequences+exhibited+a+sequence+similarity+of+100%25.+The+interaction+showed%0D%0Aresidues+in+the+repetitive+regions+of+FbsA+GBS+interacting+with+human+Fg+chains+at+D+fragment%0D%0Aand+was+dominated+by+critical+residue+groups%2C+residues+reported+to+play+crucial+roles+in%0D%0Afibrinogen+binding.+These+critical+residues+are+mainly+located+in+the+repetitive+region+from+the%0D%0A45th+to+the+60th.+Interactions+occurred+at+the+%CE%B2119-129+site%2C+the+site+of+plasmin+fibrinolytic+protein%0D%0Acleavage.+These+findings+are+suspected+to+contribute+to+the+pathogenesis+of+the+disease%2C%0D%0Aparticularly+in+the+clinical+symptoms+of+endocarditis+and+septicemia%2C+and+potentially+as+a%0D%0Azoonotic+disease+of+fish+origin.%0D%0AKeywords%3A+One-health%2C+zoonotic+disease%2C+Group+B+Streptococcus%2C+Fibrinogen-binding+protein%0D%0AA%2C+In+silico&rft.publisher=FAKULTAS+MATEMATIKA+DAN+ILMU+PENGETAHUAN+ALAM&rft.date=2024-07-12&rft.typ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