?url_ver=Z39.88-2004&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Adc&rft.title=UJI+AKTIVITAS+ANTIDIABETES+DAN+GAMBARAN%0D%0AHISTOPATOLOGI+GINJAL+PEMBERIAN+EKSTRAK+ETANOL%0D%0ADAUN+JAMBU+BIJI+(Psidium+guajava+L.)+DAN+DAUN+SIRIH%0D%0AHIJAU+(Piper+betle+L.)+PADA+TIKUS+GALUR+WISTAR+YANG%0D%0A%0D%0ADIINDUKSI+ALOKSAN&rft.creator=ASYFA+NADYA%2C+DARAZAT&rft.subject=600+Teknologi+(ilmu+terapan)&rft.subject=610+Ilmu+kedokteran%2C+ilmu+pengobatan+dan+ilmu+kesehatan&rft.description=Background%3A+Diabetes+mellitus+is+a+metabolic+disease+characterized+by%0D%0Aabnormalities+in+insulin+secretion+and+insulin+action.+Green+betel+leaves+(Piper+betle%0D%0AL.)+and+guava+leaves+(Psidium+guajava+L.)+is+one+of+the+herbal+plants+that+is+believed%0D%0Ato+be+able+to+reduce+blood+sugar+levels+and+repair+kidney+damage+because+it+contains%0D%0Asecondary+metabolite+compounds.%0D%0AMethod%3A+This+type+of+research+is+experimental+with+a+design+in+the+form+of+post+test%0D%0Acontrol+group+design.+The+samples+used+were+male+Wistar+rats+which+were+divided%0D%0Ainto+6+groups%2C+namely+healthy%2C+positive+control%2C+negative+control%2C+combined+extract%0D%0Adoses+of+200+mg%2FkgBW%2C+400+mg%2FkgBW%2C+and+600+mg%2FkgBW.+The+decrease+in+blood%0D%0Asugar+levels+can+be+seen+from+the+difference+in+decrease+on+day+1+to+day+14%2C+while%0D%0Athe+histopathological+picture+of+the+kidneys+is+tested+using+an+analysis+test.+Kruskal%0D%0AWallis+followed+by+testing+Mann-Whitney.%0D%0AResults%3A+There+was+a+decrease+in+blood+sugar+levels+after+administering+a%0D%0Acombination+of+ethanol+extract+of+green+betel+leaves+and+guava+leaves+at+doses+of%0D%0A200+mg%2Fkg+BW+and+600+mg%2Fkg+BW+with+respective+decreases+of+319.7+mg%2FdL+and%0D%0A39.4+mg%2FdL.+The+results+of+the+histopathological+test+showed+that+there+was+an+effect%0D%0Aof+giving+a+combination+of+extracts+on+the+histopathological+picture+of+the+kidneys%0D%0Aof+Wistar+rats+induced+by+alloxan+with+p-value+%3C0%2C05.%0D%0AConclusion%3A+This+research+proves+that+there+is+an+effect+of+giving+a+combination+of%0D%0Aethanol+extract+of+green+betel+leaves+and+guava+leaves+on+reducing+blood+sugar%0D%0Alevels+and+the+histopathological+picture+of+the+kidneys+of+Wistar+rats+induced+by%0D%0Aalloxan.%0D%0A%0D%0AKey+words%3A+Alloxan%2C+Kidney%2C+Diabetes%2C+Piper+betle+L.%2C+Psidium+guajava+L.%0D%0A%0D%0ALatar+Belakang%3A+Diabetes+melitus+merupakan+penyakit+metabolik+yang+ditandai%0D%0Adengan+kelainan+pada+sekresi+insulin%2C+kerja+insulin.+Daun+sirih+hijau+(Piper+betle+L.)%0D%0Adan+daun+jambu+biji+(Psidium+guajava+L.)+menjadi+salah+satu+tanaman+herbal+yang%0D%0Adipercaya+mampu+menurunkan+kadar+gula+darah+dan+memperbaiki+kerusakan+ginjal%0D%0Akarena+mengandung+senyawa+metabolit+sekunder.%0D%0AMetode%3A+Jenis+penelitian+ini+adalah+eksperimental+dengan+rancangan+berupa+post%0D%0Atest+control+group+design.+Sampel+yang+digunakan+adalah+tikus+jantan+galur+wistar%0D%0Ayang+dibagi+kedalam+6+kelompok+yaitu+sehat%2C+kontrol+positif%2C+kontrol+negatif%2C%0D%0Akombinasi+ekstrak+dosis+200+mg%2FkgBB%2C+400+mg%2FkgBB%2C+dan+600+mg%2FkgBB.%0D%0APenurunan+kadar+gula+darah+dilihat+dari+selisih+penurunan+pada+hari+ke-1+hingga%0D%0Ahari+ke-14%2C+sedangkan+gambaran+histopatologi+ginjal+diuji+menggunakan+uji+analisis%0D%0AKruskal+Wallis+yang+dilanjutkan+dengan+uji+Mann-Whitney.%0D%0AHasil%3A+Terdapat+penurunan+kadar+gula+darah+setelah+pemberian+kombinasi+ekstrak%0D%0Aetanol+daun+sirih+hijau+dan+daun+jambu+biji+pada+dosis+200+mg%2FkgBB+dan+600%0D%0Amg%2FkgBB+dengan+masing-masing+penurunan+sebesar+319%2C7+mg%2FdL+dan+39%2C4+mg%2FdL.%0D%0AHasil+uji+gambaran+histopatologi+menunjukkan+bahwa+ada+pengaruh+pemberian%0D%0Akombinasi+ekstrak+terhadap+gambaran+histopatologi+ginjal+tikus+galur+wistar+yang%0D%0Adiinduksi+aloksan+dengan+p-value+%3C0%2C05.%0D%0AKesimpulan%3A+Penelitian+ini+membuktikan+bahwa+adanya+pengaruh+pemberian%0D%0Akombinasi+ekstrak+etanol+daun+sirih+hijau+dan+daun+jambu+biji+terhadap+penurunan%0D%0Akadar+gula+darah+dan+gambaran+histopatologi+ginjal+tikus+galur+wistar+yang%0D%0Adiinduksi+aloksan.%0D%0A%0D%0AKata+kunci%3A+Aloksan%2C+Diabetes%2C+Ginjal%2C+Piper+betle+L.%2C+Psidium+guajava+L.&rft.publisher=FAKULTAS+KEDOKTERAN&rft.date=2024-07-19&rft.type=Skripsi&rft.type=NonPeerReviewed&rft.format=text&rft.identifier=http%3A%2F%2Fdigilib.unila.ac.id%2F84571%2F2%2FAbstrak_Asyfa%2520Nadya%2520Darazat%2520-%2520asyfa%2520nadia.pdf&rft.format=text&rft.identifier=http%3A%2F%2Fdigilib.unila.ac.id%2F84571%2F1%2FFull%2520tanpa%2520lampiran_Asyfa%2520Nadya%2520Darazat%2520-%2520asyfa%2520nadia.pdf&rft.format=text&rft.identifier=http%3A%2F%2Fdigilib.unila.ac.id%2F84571%2F3%2FTanpa%2520pembahasan_Asyfa%2520Nadya%2520Darazat%2520-%2520asyfa%2520nadia.pdf&rft.identifier=++ASYFA+NADYA%2C+DARAZAT++(2024)+UJI+AKTIVITAS+ANTIDIABETES+DAN+GAMBARAN+HISTOPATOLOGI+GINJAL+PEMBERIAN+EKSTRAK+ETANOL+DAUN+JAMBU+BIJI+(Psidium+guajava+L.)+DAN+DAUN+SIRIH+HIJAU+(Piper+betle+L.)+PADA+TIKUS+GALUR+WISTAR+YANG+DIINDUKSI+ALOKSAN.++FAKULTAS+KEDOKTERAN%2C+UNIVERSITAS+LAMPUNG.+++++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