?url_ver=Z39.88-2004&rft_id=2118031043&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Adc&rft.title=EKSPLORASI+AKTIVITAS+ANTIOKSIDAN+DAN+AKTIVITAS%0D%0ASITOTOKSIK+EKSTRAK+ETANOL+96%25+KULIT+BIJI+KABAU++%0D%0A(Archidendron+bubalinum)+%3A+STUDI+ANTIKANKER+PADA+%0D%0ASEL+KANKER+PAYUDARA+MCF-7&rft.creator=Kamilah+Hakim%2C+Fatiyah&rft.subject=602+Aneka+ragam+tentang+teknologi+dan+ilmu+terapan&rft.subject=607+Pendidikan%2C+riset%2C+topik+terkait&rft.subject=610+Ilmu+kedokteran%2C+ilmu+pengobatan+dan+ilmu+kesehatan&rft.description=+%0D%0ALatar+Belakang%3A+Pengobatan+kanker+terus+berkembang+pesat+seiring+dengan%0D%0Amasifnya+kejadian+kanker+di+dunia.+Salah+satu+potensi+yang+dikembangkan+saat+ini%0D%0Auntuk+pengobatan+dan+pencegahan+kanker+adalah+antioksidan+alami.+Beberapa%0D%0Apenelitian+terdahulu+melaporkan+bahwa+adanya+aktivitas+antioksidan+yang+tinggi%0D%0Apada+tanaman+kabau+(Archidendron+bubalinum).+Namun%2C+belum+ada+penelitian+yang%0D%0Amenghubungkan+tanaman+kabau+dengan+potensinya+sebagai+antikanker%2C+seperti%0D%0Akanker+payudara+yang+prevalensinya+tinggi+di+dunia.+Sehingga%2C+dalam+penelitian+ini%0D%0Adilakukan+eksplorasi+aktivitas+antioksidan+dan+aktivitas+sitotoksik+pada+sel+kanker%0D%0Apayudara+MCF-7.+%0D%0AMetode%3A+Dalam+penelitian+ini%2C+proses+ekstraksi+dilakukan+dengan+metode%0D%0AUltrasound-Assisted+Extraction+menggunakan+pelarut+etanol+96%25.+Ekstrak+kental%0D%0Aselanjutnya+dilakukan+identifikasi+senyawa+secara+kualitatif+dan+diteliti+aktivitas%0D%0Aantioksidannya+menggunakan+metode+DPPH.+Kemudian%2C+dilakukan+uji+aktivitas%0D%0Asitotoksik+pada+sel+kanker+payudara+MCF-7+menggunakan+metode+MTT.+%0D%0AHasil%3A+Ekstrak+etanol+kulit+biji+kabau+mengandung+senyawa+saponin%2C+fenolik%2C+tanin%2C%0D%0Adan+flavonoid.+Didapatkan+hasil+nilai+IC%0D%0A50+%0D%0Aaktivitas+antioksidan+yang+tinggi+sebesar%0D%0A38%2C23+mg%2FL.+Tidak+didapatkan+adanya+aktivitas+sitotoksik+yang+berarti+bahwa%0D%0Asampel+tidak+mencapai+penghambatan+50%25+pada+sel+kanker+payudara+MCF-7.+%0D%0ASimpulan%3A+Ekstrak+etanol+kulit+biji+kabau+memiliki+aktivitas+antioksidan+yang%0D%0Asangat+baik%2C+tetapi+tidak+menunjukkan+aktivitas+sitotoksik+pada+sel+kanker+payudara%0D%0AMCF-7.%0D%0A%0D%0AKata+kunci%3A+Archidendron+bubalinum%2C+Aktivitas+antioksidan%2C+Aktivitas+sitotoksik%2C%0D%0AKanker+payudara%2C+Sel+MCF-7%0D%0A+%0D%0ABackground%3A+Cancer+treatment+continues+to+evolve+rapidly+in+line+with+the%0D%0Aincreasing+incidence+of+cancer+worldwide.+One+potential+approach+currently+being%0D%0Adeveloped+for+cancer+prevention+and+treatment+is+the+use+of+natural+antioxidants.%0D%0APrevious+studies+have+reported+high+antioxidant+activity+in+the+Archidendron%0D%0Abubalinum.+However%2C+no+studies+have+linked+this+plant+to+its+anticancer+potential%2C%0D%0Aparticularly+against+breast+cancer%2C+which+has+a+high+prevalence+globally.+Therefore%2C%0D%0Athis+study+aimed+to+explore+the+antioxidant+and+cytotoxic+activities+of+Archidendron%0D%0Abubalinum+seed+shells+extract+on+MCF-7+breast+cancer+cells.%0D%0AMethods%3A+In+this+study%2C+extraction+was+performed+using+the+Ultrasound-Assisted%0D%0AExtraction+method+with+96%25+ethanol+as+the+solvent.+The+crude+extract+was+then%0D%0Aqualitatively+analyzed+for+its+compound+content+and+its+antioxidant+activity+was%0D%0Aevaluated+using+the+DPPH+method%2C+the+cytotoxic+activity+against+MCF-7+breast%0D%0Acancer+cells+was+assessed+using+the+MTT+assay.%0D%0AResult%3A+The+ethanolic+extract+of+kabau+seed+shells+contained+saponins%2C+phenolics%2C%0D%0Atannins%2C+and+flavonoids.+The+results+showed+a+high+IC%0D%0A50%0D%0A+value+for+antioxidant%0D%0Aactivity+at+38%2C23+mg%2FL.+No+significant+cytotoxic+activity+was+observed%2C+indicating%0D%0Athat+the+sample+did+not+achieve+50%25+inhibition+of+MCF-7+breast+cancer+cells.%0D%0AConclusion%3A+The+ethanolic+extract+of+kabau+seed+shells+exhibited+excellent%0D%0Aantioxidant+activity%2C+but+did+not+demonstrate+cytotoxic+activity+against+MCF-7%0D%0Abreast+cancer+cells.%0D%0A%0D%0AKeywords%3A+Archidendron+bubalinum%2C+antioxidant+activity%2C+cytotoxic+activity%2C%0D%0Abreast+cancer%2C+MCF-7+cell+line.&rft.publisher=FAKULTAS+KEDOKTERAN&rft.date=2025-01-22&rft.type=Skripsi&rft.type=NonPeerReviewed&rft.format=text&rft.identifier=http%3A%2F%2Fdigilib.unila.ac.id%2F84815%2F1%2FABSTRAK.pdf&rft.format=text&rft.identifier=http%3A%2F%2Fdigilib.unila.ac.id%2F84815%2F2%2FSKRIPSI%2520FULL.pdf&rft.format=text&rft.identifier=http%3A%2F%2Fdigilib.unila.ac.id%2F84815%2F3%2FSKRIPSI%2520FULL%2520TANPA%2520BAB%2520PEMBAHASAN.pdf&rft.identifier=++Kamilah+Hakim%2C+Fatiyah++(2025)+EKSPLORASI+AKTIVITAS+ANTIOKSIDAN+DAN+AKTIVITAS+SITOTOKSIK+EKSTRAK+ETANOL+96%25+KULIT+BIJI+KABAU+(Archidendron+bubalinum)+%3A+STUDI+ANTIKANKER+PADA+SEL+KANKER+PAYUDARA+MCF-7.++FAKULTAS+KEDOKTERAN%2C+UNIVERSITAS+LAMPUNG.+++++&rft.relation=http%3A%2F%2Fdigilib.unila.ac.id%2F84815%2F