?url_ver=Z39.88-2004&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Adc&rft.title=FORMULASI+DAN+UJI+AKTIVITAS+ANTIFUNGI+SEDIAAN%0D%0ANANOPATCH+MUKOADHESIF+EKSTRAK+DAUN+JERUK+PURUT+(Citrus%0D%0Ahystrix)+TERHADAP+JAMUR+Candida+albicans+PENYEBAB+SARIAWAN&rft.creator=Alya+%2C+Rahmah+Widodo%09&rft.subject=610+Ilmu+kedokteran%2C+ilmu+pengobatan+dan+ilmu+kesehatan&rft.description=Latar+Belakang%3A+Sariawan+adalah+kondisi+infeksi+oportunistik+pada+mukosa+mulut%0D%0Ayang+ditandai+dengan+munculnya+ulkus+dan+dikenal+dengan+istilah%0D%0Apseudomembranous+candidiasis+(Thrush).+Daun+jeruk+purut+(Citrus+hystrix)%0D%0Amengandung+metabolit+sekunder+yang+memiliki+aktivitas+antifungi+terhadap+jamur%0D%0ACandida+albicans.+Patch+mukoadhesif+menjadi+solusi+dalam+pengobatan+sariawan%0D%0Ayang+tertarget+namun+senyawa+dalam+ekstrak+daun+jeruk+purut+bersifat%0D%0Aimpermeabilitas%2C+sehingga+diperlukan+sistem+penghantaran+nanoemulsi+spontan%0D%0Auntuk+mengoptimalkan+zat+aktif+dalam+sediaan+patch.+Penelitian+ini+bertujuan+untuk%0D%0Amengetahui+konsentrasi+optimum+ekstrak+daun+jeruk+purut+dalam+menghambat%0D%0Ajamur+Candida+albicans%2C+karakteristik+sediaan+nanopatch+dan+uji+aktivitas+antifungi%0D%0Asediaan+nanopatch+terhadap+jamur+Candida+albicans.%0D%0AMetode%3A+Penelitian+ini+adalah+penelitian+eksperimental+untuk+mengetahui%0D%0Akonsentrasi+optimum+ekstrak+daun+jeruk+purut+dalam+menghambat+jamur+Candida%0D%0Aalbicans%2C+karakteristik+sediaan+nanopatch+dan+uji+aktivitas+antifungi+sediaan%0D%0Ananopatch+terhadap+jamur+Candida+albicans.%0D%0AHasil%3A+Berdasarkan+hasil+penelitian%2C+konsentrasi+optimum+ekstrak+daun+jeruk+purut%0D%0Ayaitu+10%25+dengan+diameter+zona+hambat+17%2C26+mm+termasuk+kategori+kuat.+Ekstrak%0D%0Adaun+jeruk+purut+konsentrasi+10%25+dapat+diformulasikan+menjadi+nanoemulsi%0D%0Adengan+kejernihan+yang+baik+yang+mempunyai+rerata+ukuran+partikel+295%2C2+nm%3B%0D%0Apolidispersitas+0%2C34%3B+potensial+zeta+-11%2C13+mV+dan+morfologi+yang+menunjukkan%0D%0Afase+(m%2Fa).+Nanoemulsi+daun+jeruk+purut+diformulasikan+patch+dengan+karakteristik%0D%0Aorganoleptik+edible+film+beraroma+citrus+yang+elastis%3B+dengan+ketahanan+lipatan%0D%0A%3E500+kali%3B+pH+5%3B+rerata+ketebalan+0%2C503+mm%3B+kemampuan+mukoadhesif+240+menit%3B%0D%0Adan+menghambat+aktivitas+antifungi+Candida+albicans+sebesar+24+mm+dengan%0D%0Akategori+kuat.%0D%0AKesimpulan%3A+Daun+jeruk+purut+(Citrus+hystrix)+optimal+pada+konsentrasi+10%25%0D%0Adalam+menghambat+jamur+Candida+albicans+dan+dapat+diformulasikan+menjadi%0D%0Asediaan+nanopatch+yang+mampu+menghambat+menghambat+jamur+Candida%0D%0Aalbicans.%0D%0AKata+Kunci+%3A+antifungi%2C+Candida+albicans%2C+daun+jeruk+purut%2C+nanoemulsi%2C+patch%0D%0Amukoadhesif%0D%0A%0D%0ABackground%3A+Thrush+is+an+opportunistic+infectious+condition+of+the+oral+mucosa%0D%0Acharacterized+by+the+appearance+of+ulcers+and+is+known+as+pseudomembranous%0D%0Acandidiasis+(Thrush).+Kaffir+lime+leaves+(Citrus+hystrix)+contain+secondary%0D%0Ametabolites+that+exhibit+antifungal+activity+against+Candida+albicans.%0D%0AMucoadhesive+patches+offer+a+targeted+treatment+solution+for+thrush%2C+but+the%0D%0Acompounds+in+kaffir+lime+leaf+extract+are+impermeable.+Therefore%2C+a+spontaneous%0D%0Ananoemulsion+delivery+system+is+necessary+to+optimize+the+active+substances+in+the%0D%0Apatch+preparation.+The+aim+of+this+research+was+to+determine+the+optimum%0D%0Aconcentration+of+kaffir+lime+leaf+extract+for+inhibiting+Candida+albicans+fungus%2C%0D%0Acharacterize+the+nanopatch+preparation%2C+and+evaluate+the+antifungal+activity+of+the%0D%0Ananopatch+against+Candida+albicans.%0D%0AMethods%3A+The+study+design+was+experimental%2C+focusing+on+determining+the%0D%0Aoptimum+concentration+of+kaffir+lime+leaf+extract+for+inhibiting+Candida+albicans%2C%0D%0Acharacterizing+the+nanopatch+preparation%2C+and+conducting+antifungal+activity+tests%0D%0Aagainst+Candida+albicans.%0D%0AResults%3A+The+results+revealed+that+the+optimum+concentration+of+kaffir+lime+leaf%0D%0Aextract+was+found+to+be+10%25%2C+showing+an+inhibition+zone+diameter+of+17.26+mm%0D%0Acategorized+as+strong+inhibition.+The+10%25+concentration+of+kaffir+lime+leaf+extract%0D%0Awas+successfully+formulated+into+a+nanoemulsion+with+good+clarity%2C+having+an%0D%0Aaverage+particle+size+of+295.2+nm%2C+polydispersity+of+0.34%2C+zeta+potential+of+-11.13%0D%0AmV%2C+and+a+morphology+indicating+the+phase+(m%2Fa).+The+nanoemulsion+of+kaffir+lime%0D%0Aleaves+was+used+to+formulate+patches+with+organoleptic+characteristics+of+elastic%0D%0Acitrus-scented+edible+film%2C+fold+resistance+exceeding+500+times%2C+pH+of+5%2C+average%0D%0Athickness+of+0.503+mm%2C+mucoadhesive+ability+lasting+for+240+minutes%2C+and%0D%0Aexhibiting+antifungal+activity+against+Candida+albicans+with+an+inhibition+zone+of%0D%0A24+mm%2C+classified+as+strong+inhibition.%0D%0AConclusion%3A+Kaffir+lime+leaf+extract+at+a+concentration+of+10%25+was+found+to+be%0D%0Aoptimal+for+inhibiting+Candida+albicans+and+can+be+effectively+formulated+into+a%0D%0Ananopatch+preparation+with+potent+antifungal+properties+against+Candida+albicans.%0D%0AKeywords%3A+antifungal%2C+Candida+albicans%2C+kaffir+lime+leaf%2C+nanoemulsion%2C%0D%0Amucoadhesive+patches&rft.publisher=FAKULTAS+KEDOKTERAN&rft.date=2024-04-23&rft.type=Skripsi&rft.type=NonPeerReviewed&rft.format=text&rft.identifier=http%3A%2F%2Fdigilib.unila.ac.id%2F85035%2F1%2FABSTRAK_Skripsi%2520Alya_Farmasi_FK%2520-%2520alya%2520widodo.pdf&rft.format=text&rft.identifier=http%3A%2F%2Fdigilib.unila.ac.id%2F85035%2F2%2FFull%2520Skripsi_Alya_Farmasi_FK%2520-%2520alya%2520widodo.pdf&rft.format=text&rft.identifier=http%3A%2F%2Fdigilib.unila.ac.id%2F85035%2F3%2FSkripsi%2520tanpa%2520Bab%25204_Alya_Farmasi_FK%2520-%2520alya%2520widodo.pdf&rft.identifier=++Alya+%2C+Rahmah+Widodo+++(2024)+FORMULASI+DAN+UJI+AKTIVITAS+ANTIFUNGI+SEDIAAN+NANOPATCH+MUKOADHESIF+EKSTRAK+DAUN+JERUK+PURUT+(Citrus+hystrix)+TERHADAP+JAMUR+Candida+albicans+PENYEBAB+SARIAWAN.++FAKULTAS+KEDOKTERAN%2C+UNIVERSITAS+LAMPUNG.+++++&rft.relation=http%3A%2F%2Fdigilib.unila.ac.id%2F85035%2F