?url_ver=Z39.88-2004&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Adc&rft.title=KARAKTERISASI+SENYAWA+BIOAKTIF+MIKROBA+ENDOFIT%0D%0AMANGROVE+(Avicennia+marina)+SERTA+UJI+BIOAKTIVITASNYA%0D%0ATERHADAP+Pseudomonas+aeruginosa&rft.creator=FEBRINA+%2C+DAMAYANTI+TOGATOROP&rft.subject=500+ilmu+pengetahuan+alam+dan+matematika&rft.subject=540+Kimia+dan+ilmu+yang+berhubungan&rft.description=ABSTRAK%0D%0A%0D%0A%0D%0AInfeksi+saluran+kemih+(ISK)+menjadi+masalah+yang+serius+bagi+kesehatan%0D%0Amasyarakat.+Hal+tersebut+diakibatkan+oleh+pengaruh+bakteri+patogen+salah+satunya%0D%0Adisebabkan+oleh+bakteri+Pseudomonas+aeruginosa.+Penelitian+ini+dilakukan+untuk%0D%0Amemperoleh+senyawa+bioaktif+yang+berasal+dari+fungi+endofit+mangrove+yang%0D%0Aberpotensi+sebagai+antibakteri.+Isolat+fungi+mangrove+diremajakan+pada+media%0D%0Aagar+koloid+kitin%2C+selanjutnya+dikultivasi+pada+beberapa+jenis+media+yaitu+media%0D%0Akulit+udang%2C+media+kentang+dan+media+kedelai+lalu+diinkubasi+dalam+kondisi+statis%0D%0Aselama+14+hari.+Isolat+diekstraksi+menggunakan+etil+asetat.+Ekstrak+kasar+yang%0D%0Adihasilkan%2C+diuji+awal+untuk+mengetahui+aktivitas+antibakteri+nya+terhadap+P.%0D%0Aaeruginosa+menggunakan+metode+difusi+cincin+agar.+Ekstrak+kasar+difraksinasi%0D%0Adengan+kromatografi+kolom+dan+diuji+kembali+aktivitas+nya+terhadap+P.%0D%0Aaeruginosa.+Fraksi+aktif+selanjutnya+dikarakterisasi+menggunakan+LC-MS%2FMS%0D%0Adan+FT-IR.+Dalam+penelitian+ini%2C+isolat+21AD2-LRKU3-3+diketahui+sebagai+isolat%0D%0Aunggul+penghasil+senyawa+antibakteri+dengan+aktivitas+hambatan+tertinggi%0D%0Aterhadap+P.+aeruginosa.+Karakteristik+senyawa+yang+dihasilkan+fraksi+21AD2-%0D%0ALRKU3-3+menunjukkan+adanya+senyawa+golongan+alkaloid+dengan+struktur+dasar%0D%0Aimidazol+dan+terdapat+beberapa+gugus+fungsi+antara+lain+gugus+C-N+pada+bilangan%0D%0Agelombang+1120%2C64+cm%E2%88%921%0D%0A%2C+gugus+N-H+pada+bilangan+gelombang+1568%2C13+cm%E2%88%921%0D%0A%2C%0D%0Agugus+C-C+pada+bilangan+gelombang+1247%2C94+cm%E2%88%921%0D%0A%2C+pada+bilangan+gelombang%0D%0A3446%2C79+cm%E2%88%921+menunjukkan+serapan+gugus+O-H%2C+dan+gugus+C%3DO+pada+bilangan%0D%0Agelombang+1635%2C64+cm%E2%88%921%0D%0A.%0D%0AKata+Kunci+%3A+Fungi+Endofit+Mangrove%2C+antibakteri%2C+P.aeruginosa%2C+imidazol%0D%0AABSTRACT%0D%0A%0D%0AUrinary+tract+infections+(UTIs)+are+a+serious+public+health+concern.+This+issue+is%0D%0Acaused+by+the+influence+of+pathogenic+bacteria%2C+one+of+which+is+due+to+the%0D%0Abacterium+Pseudomonas+aeruginosa.+This+study+was+conducted+to+obtain%0D%0Abioactive+compounds+derived+from+mangrove+endophytic+fungi+that+have+potential%0D%0Aas+antibacterial+agents.+Mangrove+fungi+isolates+were+maintained+on+chitin+colloid%0D%0Aagar+media%2C+then+cultivated+on+several+types+of+media%2C+namely+shrimp+shell+media%2C%0D%0Apotato+media%2C+and+soybean+media%2C+and+incubated+under+static+conditions+for+14%0D%0Adays.+The+isolates+were+extracted+using+ethyl+acetate.+The+resulting+crude+extracts%0D%0Awere+initially+tested+for+their+antibacterial+activity+against+P.+aeruginosa+using+the%0D%0Aagar+diffusion+method.+The+crude+extracts+were+fractionated+using+column%0D%0Achromatography+and+then+retested+for+their+activity+against+P.+aeruginosa.+The%0D%0Aactive+fractions+were+further+characterized+using+LC-MS%2FMS+and+FT-IR.+In+this%0D%0Astudy%2C+the+21AD2-LRKU3-3+isolate+was+identified+as+the+superior+isolate%0D%0Aproducing+antibacterial+compounds+with+the+highest+inhibitory+activity+against+P.%0D%0Aaeruginosa.+The+characteristics+of+the+compounds+produced+by+the+21AD2-%0D%0ALRKU3-3+fraction+indicated+the+presence+of+alkaloid+compounds+with+an%0D%0Aimidazole+core+structure+and+several+functional+groups%2C+including+the+C-N+group+at%0D%0Aa+wavenumber+of+1120%2C64+cm%E2%88%921%0D%0A%2C+the+N-H+group+at+a+wavenumber+of+1568%2C13%0D%0Acm%E2%88%921%0D%0A%2C+the+C-C+group+at+a+wavenumber+of+1247%2C94+cm%E2%88%921%0D%0A%2C+At+a+wavenumber+of%0D%0A3446%2C79+cm%E2%88%921%0D%0A%2C+it+indicates+the+absorption+of+the+O-H+group%2C+and+the+C%3DO+group+at%0D%0Aa+wavenumber+of+1635%2C64+cm%E2%88%921%0D%0A.%0D%0AKeywords+%3A+Mangrove+endophytic+fungi%2C+antibacterial%2C+P.aeruginosa%2C+imidazole&rft.publisher=FAKULTAS+MATEMATIKA+DAN+ILMU+PENGETAHUAN+ALAM+&rft.date=2024-10-22&rft.type=Skripsi&rft.type=NonPeerReviewed&rft.format=text&rft.identifier=http%3A%2F%2Fdigilib.unila.ac.id%2F85093%2F1%2FABSTRAK%2520Febrina%2520Damayanti%2520Togatorop%2520-%2520Febrina%2520Togatorop.pdf&rft.format=text&rft.identifier=http%3A%2F%2Fdigilib.unila.ac.id%2F85093%2F2%2FSKRIPSI%2520FULL%2520Febrina%2520Damayanti%2520Togatorop%2520-%2520Febrina%2520Togatorop.pdf&rft.format=text&rft.identifier=http%3A%2F%2Fdigilib.unila.ac.id%2F85093%2F3%2FSKRIPSI%2520TANPA%2520BAB%2520PEMBAHASAN%2520Febrina%2520Damayanti%2520Togatorop%2520-%2520Febrina%2520Togatorop.pdf&rft.identifier=++FEBRINA+%2C+DAMAYANTI+TOGATOROP++(2024)+KARAKTERISASI+SENYAWA+BIOAKTIF+MIKROBA+ENDOFIT+MANGROVE+(Avicennia+marina)+SERTA+UJI+BIOAKTIVITASNYA+TERHADAP+Pseudomonas+aeruginosa.++FAKULTAS+MATEMATI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