%0 Generic
%A 	Annisa,  Salshabilla
%C UNIVERSITAS LAMPUNG 
%D 2024
%F eprints:85294
%I KEDOKTERAN
%T HUBUNGAN POTENSI INTERAKSI OBAT DENGAN  LAMA RAWAT INAP PADA PASIEN PNEUMONIA  DI RSD DR. A. DADI TJOKRODIPO BANDAR LAMPUNG
%U http://digilib.unila.ac.id/85294/
%X Background: Pneumonia is a lower respiratory tract infection caused by  bacteria. The incidence of pneumonia in Indonesia in 2018 was 1,017,290  cases. Most hospitalized pneumonia patients receive ≥ 5 types so they are at  risk of drug interactions. The aim of this study was to identify drug  interactions and analyze their relationship with length of stay.  Methods: The study used a cross-sectional method and collected data  retrospectively. The subjects of this research were pneumonia patients at the  RSD Dr. A. Dadi Tjokrodipo for the period 2023. Data analysis using the    Drugs.com application and Stokley's Drug Interaction book and using chi-  square analysis to determine the relationship between potential drug    interactions and length of stay.  Results: Of the 92 patients, the patient characteristics were predominantly  male (52.2%) and patients ≥ 60 years old (55.4%). Potential drug interactions  were noted in 60 (64.5%) patients. Interactions based on minor, moderate,  and major severity were 20.2%, 66.0%, and 13.8%, respectively. Interactions  based on pharmacodynamic, pharmacokinetic and unknown mechanisms of  drug interactions were 61.7%, 29.3% and 9.0% respectively. The bivariate  results of the relationship between drug interactions and length of stay in  hospital showed a p-value of 0.409.  Conclusion: There is no relationship between potential drug interactions and  the length of stay in pneumonia patients.  Keywords: Drug Interactions, Length of Hospitalization, Pneumonia  Latar Belakang: Pneumonia adalah infeksi saluran pernapasan bawah yang  disebabkan oleh bakteri. Kejadian pneumonia di Indonesia pada tahun 2018  sebanyak 1.017.290 kasus. Sebagian besar pasien pneumonia rawat inap  menerima ≥ 5 jenis sehingga berisiko mengalami interaksi obat. Tujuan  penelitian ini untuk mengidentifikasi interaksi obat dan menganalisis  hubungannya dengan lama rawat inap.  Metode: Penelitian ini menggunakan metode cross-sectional dan  pengambilan data dilakukan secara retrospektif. Subjek penelitian ini adalah  pasien pneumonia di instalasi rawat inap RSD Dr. A. Dadi Tjokrodipo  periode 2023. Analisis data menggunakan aplikasi Drugs.com dan buku  Stokley’s Drug Interaction serta menggunakan analisis chi-square untuk  mengetahui hubungan antara potensi interaksi obat dengan lama rawat inap.  Hasil: Dari 92 pasien menunjukkan karakteristik pasien yang didominasi oleh  laki-laki (52.2%) serta pasien ≥ 60 tahun (55,4%). Potensi interaksi obat  didapatkan pada 60 (64.5%) pasien. Interaksi berdasarkan tingkat keparahan  minor, moderat, dan mayor masing-masing sebesar 20.2%, 66.0%, dan  13.8%. Interaksi berdasarkan mekanisme interaksi obat farmakodinamik,  farmakokinetik dan mekanisme tidak diketahui masing-masing sebesar  61.7%, 29.3%, dan 9.0%. Hasil bivariat hubungan interaksi obat dengan lama  rawat inap didapatkan p-value sebesar 0,409.  Kesimpulan: Tidak terdapat hubungan antara potensi interaksi obat dengan  lama rawat inap pasien pneumonia.  Kata kunci: Interaksi Obat, Lama Rawat Inap, Pneumonia