?url_ver=Z39.88-2004&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Adc&rft.title=PENGARUH+PEMBERIAN+EKSTRAK+ETANOL+95%25+KULIT+BATANG%0D%0ABAKAU+MINYAK+(Rhizophora+apiculata)+TERHADAP+PERBAIKAN%0D%0AKERUSAKAN+TUBULUS+KONTORTUS+PROKSIMAL+GINJAL+TIKUS%0D%0APUTIH+JANTAN+(Rattus+norvegicus)+GALUR+Sprague-dawley+YANG%0D%0ADIBERI+N-Acetyl-para-aminophenol&rft.creator=%09Farah+%2C+Hanifah%09&rft.subject=610+Ilmu+kedokteran%2C+ilmu+pengobatan+dan+ilmu+kesehatan&rft.description=Background%3A+N-acetyl-para-aminophenol%2C+commonly+available+as+an+over-the-counter+medication%2C+poses+a+risk%0D%0Aof+inadvertent+or+deliberate+overdose+incidents.+Such+occurrences+are+prevalent+in+clinical+settings.+The%0D%0Aadministration+of+excessive+doses+of+N-acetyl-para-aminophenol+is+known+to+induce+nephrotoxic+effects.%0D%0ARhizophora+apiculata%2C+distinguished+by+its+rich+antioxidant+content%2C+particularly+tannins%2C+underscores+the+potential%0D%0Aof+mangrove+bark+extract+as+an+antioxidant+agent.+The+aim+of+this+study+was+to+determine+the+effect+of+repairing%0D%0Adamage+to+rat+kidney+tubules+induced+by+N-Acetyl-para-aminophenol+after+administration+of+95%25+ethanol+extract%0D%0Aof+mangrove+bark+oil.+Methods%3A+Employing+a+true+experimental+approach%2C+this+study+adopted+the+posttest+only%0D%0Acontrol+group+method+over+a+duration+of+15+days.+The+study+sample+comprised+30+rats+distributed+across+five%0D%0A%0D%0Agroups%3A+K%2B+(standardized+feed+and+water)%2C+K-+(N-acetyl-para-aminophenol+500+mg%2FkgBW)%2C+P1%2C+P2%2C+and+P3+(N-%0D%0Aacetyl-para-aminophenol+500+mg%2FkgBW+%2B+14%3B+28%3B+56+mg%2FkgBW+mangrove+bark+extract%2C+respectively).+Evaluation%0D%0A%0D%0Awas+conducted+through+the+microscopic+examination+of+rat+kidney+histology+at+400x+magnification+across+five%0D%0Adistinct+fields.+Result%3A+Analysis+of+the+data+presented%0D%0Arevealed+mean+proximal+tubular+damage+scores+in+the+following+order%3A+K-%2C+K%2B%2C+P1%2C+P2%2C+and+P3%2C+registering+values%0D%0Aof+0.24%2C+1.48%2C+0.96%2C+1%2C+and+1.08%2C+respectively.+The+Kruskal-Wallis+test+yielded+a+statistically+significant+p-value+of%0D%0A0.016%2C+warranting+the+rejection+of+the+null+hypothesis.+Subsequent+analysis+unveiled+significant+intergroup%0D%0Adisparities+(p+-+value+%3C+0.05).+Noteworthy+differentiations+were+observed+between+the+K(%2B)+group+and+P1+(p+%3D%0D%0A0.023)%2C+P2+(p+%3D+0.021)%2C+P3+(p+%3D+0.011)%2C+and+K(-)+(p+%3D+0.001)+groups.+Conclusion%3A+Based+on%0D%0Athese+results%2C+it+can+be+said+that+induction+of+standard+feed+and+drink+can+influence+the+histopathological+picture%0D%0Aof+the+proximal+tubules+of+the+kidneys+of+white+rats.+Keywords%3AKidney+Histopathology%2C+Mangrove+Bark+Oil%0D%0AExtract%2C+N-acetyl-para-aminophenol.%0D%0ALatar+Belakang%3A+N-acetyl-para-aminophenol+tergolong+obat+bebas+dan+mudah+didapat+yang+menyebabkan%0D%0Akejadian+overdosis+obat+baik+sengaja+atau+tidak%2C+sering+terjadi.+N-acetyl-para-aminophenol+yang+digunakan%0D%0Adengan+dosis+berlebih+dapat+menyebabkan+efek+nefrotoksik.+Rhizophora+apiculata+mengandung+antioksidan%2C+yaitu%0D%0Atannin+sebagai+senyawa+utamanya+yang+menunjukkan+ekstrak+kulit+batang+bakau+merupakan+bagian+potensial%0D%0Asebagai+antioksidan.+Tujuan+Penelitian+ini+untuk+mengetahui+pengaruh+perbaikan+kerusakan+tubulus+ginjal+tikus%0D%0Ayang+diinduksi+dengan+N-Acetyl-para-aminophenol+setelah+pemberian+etanol+95%25+ekstrak+kulit+batang+bakau.%0D%0AMetode%3A+Penelitian+ini+menggunakan+true+eksperimental+dengan+metode+post+test+only+control+grup+dan%0D%0Adilakukan+selama+15+hari.+Sampel+yang+digunakan+30+ekor+tikus+yang+dibagi+dalam+5+kelompok%2C+yaitu+K%2B+(pakan%0D%0A%0D%0Adan+minum+standar)%2C+K-+(N-acetyl-para-aminophenol+500+mg%2FKgBB)%2C+P1%2C+P2%2C+dan+P3+(N-acetyl-para-%0D%0Aaminophenol+500+mg%2FKgBB+%2B+14%3B+28%3B+56+mg%2FkgBB+ekstrak+kulit+batang+bakau+secara+berurutan).+Penilaian+dengan%0D%0A%0D%0Amengamati+gambaran+mikroskopis+ginjal+tikus+5+lapang+pandang+dengan+perbesaran+400x.%0D%0AHasil%3A+Berdasarkan+tabel+di+atas+dapat+diketahui+rerata+skor+kerusakan+tubulus+proksimal+secara+berurutan+K-%2C+K%2B%2C%0D%0AP1%2C+P2%2C+P3+yaitu+0.24%3B+1.48%3B+0.96%3B+1%3B+dan+1.08.+Uji+Kruskal-Wallis+yaitu+sebesar+0%2C016+yang+artinya+H_0+ditolak.%0D%0Adidapatkan+bahwa+terdapat+data+yang+memiliki+perbedaan+yang+bermakna+antara+dua+kelompok+(p-value+%3C0%2C05).%0D%0AKelompok+perlakuan+yang+memiliki+perbedaan+yang+bermakna+adalah+K+(%2B)+dengan+P1+(p+%3D+0%2C023)%2C+K+(%2B)+dengan%0D%0AP2+(p+%3D+0%2C021)%2C+K+(%2B)+dengan+P3+(p+%3D+0%2C011)%2C+serta+K+(%2B)+dengan+K+(-)+(p+%3D+0%2C001).%0D%0AKesimpulan%3A+Berdasarkan+hasil+tersebut+dapat+dikatakan+bahwa+induksi+diberi+pakan+dan+minum+standar+dapat%0D%0Amempengaruhi+gambaran+histopatologi+tubulus+kontortus+proksimal+ginjal+tikus+putih.%0D%0AKata+Kunci%3A+Histopatologi+Ginjal%2C+Kulit+Batang+Bakau+Minyak%2C+N-acetyl-para-aminophenol.&rft.publisher=KEDOKTERAN&rft.date=2024-05-08&rft.type=Skripsi&rft.type=NonPeerReviewed&rft.format=text&rft.identifier=http%3A%2F%2Fdigilib.unila.ac.id%2F85484%2F1%2Fabstrak%2520skripsi%2520-%2520Farah%2520Hanifah.pdf&rft.format=text&rft.identifier=http%3A%2F%2Fdigilib.unila.ac.id%2F85484%2F2%2Fskripsi_farah%2520hanifah-3%2520-%2520Farah%2520Hanifah.pdf&rft.format=text&rft.identifier=http%3A%2F%2Fdigilib.unila.ac.id%2F85484%2F3%2Fskripsi%2520tanpa%2520pembahasan-1%2520-%2520Farah%2520Hanifah.pdf&rft.identifier=+++Farah+%2C+Hanifah+++(2024)+PENGARUH+PEMBERIAN+EKSTRAK+ETANOL+95%25+KULIT+BATANG+BAKAU+MINYAK+(Rhizophora+apiculata)+TERHADAP+PERBAIKAN+KERUSAKAN+TUBULUS+KONTORTUS+PROKSIMAL+GINJAL+TIKUS+PUTIH+JANTAN+(Rattus+norvegicus)+GALUR+Sprague-dawley+YANG+DIBERI+N-Acetyl-para-aminophenol.++KEDOKTERAN%2C+UNIVERSITAS+LAMPUNG.+++++&rft.relation=http%3A%2F%2Fdigilib.unila.ac.id%2F85484%2F