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<http://digilib.unila.ac.id/id/eprint/87022> <http://purl.org/dc/terms/title> "EFFECT OF GREEN TEA (Camellia sinensis) LEAF ETHANOL EXTRACT ON\r\nWOUND HEALING IN RABBITS CORNEAL ULCER MODEL\r\n\r\nINDUCED BY Staphylococcus aureus\r\n"^^<http://www.w3.org/2001/XMLSchema#string> .
<http://digilib.unila.ac.id/id/eprint/87022> <http://purl.org/ontology/bibo/abstract> "Backround: Scar tissue production due to corneal ulcers is a major cause of blindness and\r\nvisual impairment so antibiotic adjuvant therapy is needed to prevent this risk. One of the plants\r\nthat can be developed is green tea (Camellia sinensis) as an adjuvant therapy.\r\nMethods: Green tea leaf samples were macerated with 96% ethanol, then evaporated. The\r\nextract was diluted into four concentrations, namely 2%, 4%, 8%, and 10%. The therapeutic\r\neffect test used rabbit corena ulcer model induced by Staphylococcus aureus as the object of\r\nresearch. The dependent variables in this study were wound healing time and the average area\r\n\r\nof scar tissue formed. Statistical tests used in this study were Mann-Whitney test and Kruskal-\r\nWallis test.\r\n\r\nResults: Wound healing time in the 10% extract concentration group was faster, which was <2\r\nweeks (p value<0.05). Measurement of the mean area of scarring in the control group, 2%, 4%,\r\n8%, and 10% extract concentrations, obtained results of 5.6 mm2\r\n, 3.3 mm2\r\n, 2.6 mm2\r\n, 0.9 mm2\r\n,\r\n\r\nand 1.8 mm2\r\n\r\n(p value=0.006). The concentration of the extract given was inversely proportional\r\n\r\nto the average area of scarring formed, except at a concentration of 10%.\r\nConclusions: Green tea leaf extract (Camellia sinensis) was shown to accelerate wound\r\nhealing time and reduce scar tissue formation in rabbit corneal ulcer models induced by\r\nStaphylococcus aureus.\r\n\r\nKeywords: Camellia sinensis, corneal ulcer, Staphylococcus aureus.\r\n\r\nABSTRAK\r\n\r\nEFEK EKSTRAK ETANOL DAUN TEH HIJAU (Camellia sinensis)\r\nTERHADAP PENYEMBUHAN LUKA PADA KELINCI MODEL\r\nULKUS KORNEA YANG DIINDUKSI Staphylococcus aureus\r\n\r\nOleh\r\nRofi Yoga Ardandi\r\n\r\nLatar Belakang: Produksi jaringan parut akibat ulkus kornea merupakan penyebab utama\r\nkebutaan dan gangguan penglihatan sehingga diperlukan terapi adjuvant antibiotik untuk\r\nmencegah risiko tersebut. Salah satu tanaman yang dapat dikembangkan adalah teh hijau\r\n(Camellia sinensis) sebagai terapi adjuvant.\r\nMetode: Sampel daun daun teh hijau dimaserasi dengan etanol 96%, kemudian dilakukan\r\nevaporasi. Ekstrak diencerkan menjadi empat konsentrasi, yaitu 2%, 4%, 8%, dan 10%. Uji\r\nefek terapi menggunakan hewan coba kelinci model ulkus korena yang diinduksi oleh\r\nStaphylococcus aureus sebagai objek penelitian. Variabel terikat pada penelitian ini adalah\r\nwaktu penyembuhan luka dan rata-rata luas jaringan parut yang terbentuk. Uji statistik yang\r\ndigunakan pada penelitian ini adalah uji Mann-Whitney dan uji Kruskal-Wallis.\r\nHasil: Waktu penyembuhan luka pada kelompok konsentrasi ekstrak 10% berjalan lebih cepat,\r\nyaitu <2 minggu (nilai p<0,05). Pengukuran rerata luas jaringan parut pada kelompok kontrol,\r\nkonsentrasi ekstrak 2%, 4%, 8%, dan 10%, didapatkan hasil sebesar 5,6 mm2\r\n, 3,3 mm2\r\n, 2,6\r\n\r\nmm2\r\n, 0,9 mm2\r\n, dan 1,8 mm2\r\n\r\n(nilai p=0,006). Konsentrasi ekstrak yang diberikan berbanding\r\nterbalik dengan rata-rata luas jaringan parut yang terbentuk, kecuali pada konsentrasi 10%.\r\nKesimpulan: Ekstrak daun teh hijau (Camellia sinensis) terbukti dapat mempercepat waktu\r\npenyembuhan luka dan mengurangi pembentukan jaringan parut pada kelinci model ulkus\r\nkornea yang diinduksi oleh Staphylococcus aureus.\r\n\r\nKata kunci: Camellia sinensis, ulkus kornea, Staphylococcus aureus."^^<http://www.w3.org/2001/XMLSchema#string> .
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