?url_ver=Z39.88-2004&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Adc&rft.title=UJI+AKTIVITAS+ANALGESIK+TUNGGAL+DAN+KOMBINASI+EKSTRAK%0D%0AETANOL+DAUN+MANGROVE+(Avicennia+alba+Blume.)+DAN+DAUN%0D%0ASIRSAK+(Annona+muricata+L.)+TERHADAP+MENCIT+(Mus+musculus%0D%0ALinneaus%2C+1758)+DENGAN+METODE+WRITHING+TEST&rft.creator=%09Iin%2C++Irianingsih+%09&rft.subject=500+ilmu+pengetahuan+alam+dan+matematika&rft.subject=570+Biologi&rft.description=Obat+analgesik+digunakan+untuk+menghilangkan+dan+mengurangi+rasa+nyeri+akibat%0D%0Akerusakan+jaringan%2C+inflamasi%2C+atau+disfungsi+sistem+saraf.+Upaya+yang+dilakukan+untuk%0D%0Amengurangi+rasa+nyeri+salah+satunya+dengan+menggunakan+obat+golongan+Non+Steroid%0D%0AAnti+Inflammatory+Drug+(NSAID).+Penggunaan+obat+NSAID+jangka+panjang+memiliki%0D%0Aefek+samping+seperti+gangguan+saluran+pencernaan%2C+kerusakan+ginjal%2C+hati+dan+alergi%0D%0Akulit%2C+sehingga+diperlukan+alternatif+obat+herbal+yang+memiliki+efek+samping+yang+lebih%0D%0Arendah%2C+salah+satunya+yaitu+dengan+menggunakan+daun+mangrove+(Avicennia+alba%0D%0ABlume.)+dan+daun+sirsak+(Annona+muricata+L.).+Senyawa+metabolit+sekunder+flavonoid%0D%0Adan+tannin+ekstrak+daun+mangrove+(Avicennia+alba+Blume.)+dan+daun+sirsak+(Annona%0D%0Amuricata+L.)+dapat+berfungsi+sebagai+analgesik+dengan+menghambat+mediator+inflamasi%0D%0Asehingga+pelepasan+asam+arakidonat+dan+memblokir+kerja+enzim+siklooksigenase.%0D%0APenelitian+ini+bertujuan+mengetahui+aktivitas+analgesik+ekstrak+etanol+daun+mangrove%0D%0Adan+daun+sirsak+terhadap+mencit+jantan+dengan+metode+writhing+test.+Penelitian+ini%0D%0Amerupakan+penelitian+eksperimen+posttest+only+control+design+menggunakan+metode%0D%0Awrithing+test.+Sampel+penelitian+terdiri+dari+25+mencit+terbagi+dalam+lima+kelompok%0D%0Ayakni+kelompok+kontrol+negatif+Na-CMC+0%2C5+%25%2C+kelompok+kontrol+positif+asam%0D%0Amefenamat%2C+kelompok+dosis+tunggal+ekstrak+etanol+daun+mangrove+250mg%2FkgBB%2C%0D%0Akelompok+dosis+tunggal+ekstrak+daun+sirsak+250mg%2FkgBB%2C+dan+kelompok+kombinasi%0D%0Aekstrak+etanol+daun+mangrove+dan+sirsak+1%3A1+dilanjutkan+seluruh+perlakuan+diinduksi%0D%0Aasam+asetat+1%25.+Data+dianalisis+secara+statistik+dengan+uji+ANOVA+dengan+uji+lanjut%0D%0ALeast+Signifinance+Difference+(LSD)+pada+taraf+signifikansi+5%25.+Hasil+uji+LSD+yang%0D%0Adiperoleh+menunjukkan+bahwa+ada+perbedaan+yang+signifikan+antara+pemberian+ekstrak%0D%0Aetanol+daun+mangrove+(P1)%2C+ekstrak+etanol+daun+sirsak+(P2)%2C+dan+kombinasi+ekstrak%0D%0Aetanol+daun+mangrove+dan+sirsak+(P3)+terhadap+kontrol+negatif+(%CF%81+%3D+0%2C000).+Namun+P3%0D%0Amenunjukkan+tidak+terdapat+perbedaan+signifikan+dengan+kontrol+positif+(asam%0D%0Amefenamat)%2C+sehingga+dapat+dikatakan+bahwa+daya+analgesik+P3+setara+dengan+kontrol%0D%0Apositif.+Kesimpulan+pada+penelitian+ini+yaitu+ekstrak+etanol+daun+mangrove+memiliki%0D%0Aaktivitas+analgesik+dengan+persentase+proteksi+geliat+sebesar+30%2C5%25+dan+persentase%0D%0Aefektivitas+analgesik+sebesar+64%2C2%25%2C+ekstrak+etanol+daun+sirsak+memiliki+aktivitas%0D%0Aanalgesik+dengan+persentase+proteksi+geliat+sebesar+23%2C99%25+dan+persentase+efektivitas%0D%0Aanalgesik+sebesar+41%2C21%25%2C+serta+kombinasi+ekstrak+etanol+daun+mangrove+dan+daun%0D%0Asirsak+memiliki+aktivitas+analgesik+dengan+persentase+proteksi+geliat+sebesar+40%2C75%25%0D%0Adan+persentase+efektivitas+analgesik+sebesar+87%2C93%25+.%0D%0AKata+kunci+%3A+Analgesik%2C+Annona+muricata+L%2C+Avicennia+alba%0D%0AAnalgesic+drugs+are+used+to+eliminate+and+reduce+pain+due+to+tissue+damage%2C%0D%0Ainflammation%2C+or+nervous+system+dysfunction.+Efforts+are+made+to+relieve+pain+by+using%0D%0Anon-steroidal+anti-inflammatory+drugs+(NSAIDs).+Long-term+use+of+NSAIDs+has+side%0D%0Aeffects+such+as+digestive+tract+disorders%2C+kidney+and+liver+damage%2C+and+skin+allergies%2C+so%0D%0Aalternative+herbal+medicines+are+needed+that+have+lower+side+effects%2C+one+of+which+is+using%0D%0Amangrove+leaves+(Avicennia+alba+Blume.)+and+soursop+leaves+(Annona+muricata+L.).%0D%0ASecondary+metabolite+compounds+of+flavonoids+and+tannins%2C+a+combination+of+mangrove%0D%0A(Avicennia+alba)+and+soursop+leaf+(Annona+muricata+L.)+leaf+extracts%2C+function+as+an%0D%0Aanalgesic+by+inhibiting+inflammatory+mediators+so+that+the+release+of+arachidonic+acid+and%0D%0Athe+action+of+the+cyclooxygenase+enzyme+are+blocked.+This+research+aims+to+determine%0D%0Athe+analgesic+activity+of+mangrove+leaf+and+soursop+leaf+extracts+on+male+mice+using+the%0D%0Awrithing+test+method.+This+research+is+a+posttest-only+control+design+experimental%0D%0Aresearch+using+the+writing+test+method.+The+research+sample+consisted+of+25+mice+divided%0D%0Ainto+five+groups%2C+namely+the+negative+control+group+Na-CMC+0.5%25+(K-)%2C+the+positive%0D%0Acontrol+group+mefenamic+acid+(K%2B)%2C+the+third+group+a+single+dose+of+ethanol+extract+of%0D%0Amangrove+leaves+250mg%2FkgBB%2C+the+fourth+group+a+single+dose+of+single+soursop+leaf%0D%0Aextract+250mg%2FkgBB%2C+the+fifth+group+was+a+combination+of+ethanol+extract+of+mangrove%0D%0Aand+soursop+leaves+1%3A1+followed+by+all+treatments+induced+by+1%25+acetic+acid.+The+data%0D%0Awere+analyzed+statistically+using+the+ANOVA+test+with+the+Least+Significance+Difference%0D%0A(LSD)+test+at+a+significance+level+of+5%25.+The+LSD+test+results+obtained+showed+that+there%0D%0Awas+a+significant+difference+between+administering+mangrove+leaf+ethanol+extract+(P1)%2C%0D%0Asoursop+leaf+ethanol+extract+(P2)%2C+and+a+combination+of+mangrove+and+soursop+leaf%0D%0Aethanol+extract+(P3)+to+the+negative+control+(%CF%81+%3D+0.000).+However%2C+P3+shows+that+there+is%0D%0Ano+significant+difference+with+the+positive+control+(mefenamic+acid)%2C+so+it+can+be+said+that%0D%0Athe+analgesic+power+of+P3+is+equivalent+to+the+positive+control.+This+research+concludes%0D%0Athat+the+ethanol+extract+of+mangrove+leaves+has+analgesic+activity+with+a+writhing%0D%0Aprotection+percentage+of+30.5%25+and+an+analgesic+effectiveness+percentage+of+64.2%25%2C+the%0D%0Asoursop+leaf+ethanol+extract+has+analgesic+activity+with+a+writhing+protection+percentage%0D%0Aof+23.99%25%2C+and+an+effectiveness+percentage+analgesia+of+41.21%25%2C+and+the+combination+of%0D%0Aethanol+extract+of+mangrove+leaves+and+soursop+leaves+has+analgesic+activity+with+a%0D%0Astretching+protection+percentage+of+40.75%25+and+an+analgesic+effectiveness+percentage+of%0D%0A87.93%25.%0D%0AKey+words%3A+Analgesic%2C+Annona+muricata+L%2C+Avicennia+alba+Blume.&rft.publisher=FAKULTAS+MATEMATIKA+DAN+ILMU+PENGETAHUAN+ALAM+&rft.date=2024-07-12&rft.type=Skripsi&rft.type=NonPeerReviewed&rft.format=text&rft.identifier=http%3A%2F%2Fdigilib.unila.ac.id%2F87516%2F1%2FABSTRAK%2520-%2520Iin%2520Iriany11.pdf&rft.format=text&rft.identifier=http%3A%2F%2Fdigilib.unila.ac.id%2F87516%2F2%2FSkripsi%2520Full.%2520pdf%2520-%2520Iin%2520Iriany11.pdf&rft.format=text&rft.identifier=http%3A%2F%2Fdigilib.unila.ac.id%2F87516%2F3%2FSkripsi%2520Tanpa%2520Pembahasan%2520-%2520Iin%2520Iriany11.pdf&rft.identifier=+++Iin%2C+Irianingsih+++(2024)+UJI+AKTIVITAS+ANALGESIK+TUNGGAL+DAN+KOMBINASI+EKSTRAK+ETANOL+DAUN+MANGROVE+(Avicennia+alba+Blume.)+DAN+DAUN+SIRSAK+(Annona+muricata+L.)+TERHADAP+MENCIT+(Mus+musculus+Linneaus%2C+1758)+DENGAN+METODE+WRITHING+TEST.++FAKULTAS+MATEMATIKA+DAN+ILMU+PENGETAHUAN+ALAM+%2C+UNIVERSITAS+LAMPUNG.+++++&rft.relation=http%3A%2F%2Fdigilib.unila.ac.id%2F87516%2F