?url_ver=Z39.88-2004&rft_id=2117021049+&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Adc&rft.title=PENURUNAN+KADAR+ASAM+URAT+DAN+PERUBAHAN+STRUKTUR+HISTOPATOLOGI+GINJAL+PADA+MENCIT+(Mus+musculus+(Linnaeus%2C+1758))+SETELAH+PEMBERIAN+EKSTRAK+ETANOL++DAUN+KERSEN+(Muntingia+calabura+L.)+&rft.creator=Yulia%2C++Rahmadina&rft.subject=500+ilmu+pengetahuan+alam+dan+matematika&rft.subject=570+Biologi&rft.description=Asam++urat++dengan++jumlah++tinggi++dalam++darah++dapat++menyebabkan++kondisi+hiperurisemia.++Kondisi++ini++berpotensi++menyebabkan++kerusakan++pada++organ++ginjal+karena++terganggunya++fungsi++ginjal++dalam++menyaring++darah.++Kersen++(Muntingia+calabura+L.)+merupakan+tumbuhan+yang+dipercaya+dapat+menurunkan+kadar+asam+urat+karena+mengandung+senyawa+flavonoid+yang+dapat+menghambat+kerja+enzim+xantin++oksidase%2C++yang++berperan++dalam++pembentukan++asam++urat.++Penelitian++ini+bertujuan++untuk++mengetahui++efektivitas++ekstrak++etanol++daun++kersen++dalam+menurunkan+kadar+asam+urat+pada+mencit+(Mus+musculus+(Linnaeus%2C+1758))%2C+dan+perubahan+struktur+histopatologi+pada+ginjal+mencit+yang+meliputi+kerusakan+pada+glomerulus+dan+tubulus.+Untuk+menginduksi+pembentukan+asam+urat+pada+mencit+digunakan++jus++hati++ayam++dan++kalium++oksonat++dosis++250++mg%2FkgBB.++Penelitian++ini+menggunakan+24+ekor+mencit+jantan+dengan+strain+BALB%2Fc+berumur+2-3+bulan+dan+berat++badan++25-35++gram%2C++yang++dibagi++menjadi++enam++kelompok++yaitu++K0++(pakan+standar++dan++hanya++diinduksi++CMC++Na++1%25)%2C++K-++(diinduksi++CMC++Na++1%25)%2C++K%2B+(diinduksi+allopurinol+10+mg%2FkgBB)%2C+dan+kelompok+P1%2C+P2%2C+dan+P3+diinduksi+daun+kersen++dengan++dosis++masing-masing++70++mg%2FkgBB%2C++140++mg%2FkgBB++dan++210+mg%2FkgBB+selama+14+hari.+Pengukuran+kadar+asam+urat+dilakukan+pada+hari+ke-1+setelah++aklimatisasi%2C++hari++ke-8++setelah++induksi++kalium++oksonat%2C++dan++pada++hari+terakhir++pemberian++ekstrak++etanol++daun++kersen++yaitu++pada++hari++ke-23++sekaligus+dilakukan+pengambilan+organ+ginjal.+Hasil+penelitian+menunjukkan+bahwa+ekstrak+etanol+daun+kersen+dapat+menurunkan+kadar+asam+urat+dan+kerusakan+pada+tubulus+kontortus+distal%2C+tubulus+kontortus+proksimal%2C+dan+glomerulus+mencit+hiperurisemia+dengan+perlakuan+P3+memiliki+efektivitas+tertinggi.+Hal+ini+dikarenakan+kandungan+metabolit+yang+lebih+banyak+dibandingkan+perlakuan+lain%2C+senyawa+metabolit+yang+bersifat+antihiperurisemia+pada+daun+kersen+antara+lain+flavonoid+dan+saponin.%0D%0AKata+kunci%3A+Asam+urat%2C+ginjal%2C+glomerulus%2C+kalium+oksonat%2C+kersen%2C+tubulus%0D%0A%0D%0AHigh++levels++of++uric++acid++in++the++blood++can++lead++to++a++condition++known++as+hyperuricemia.++This++condition++has++the++potential++to++cause++kidney++damage++due++to+impaired+kidney+function+in+filtering+blood.+Kersen+(Muntingia+calabura+L.)+is+a+plant+believed+to+reduce+uric+acid+levels%2C+as+it+contains+flavonoid+compounds+that+can+inhibit+the+activity+of+the+xanthine+oxidase+enzyme%2C+which+plays+a+role+in+uric+acid+formation.+This+study+aims+to+determine+the+effectiveness+of+ethanolic+extract+of++kersen++leaves++in++lowering++uric++acid++levels++in++mice++(Mus++musculus++(Linnaeus%2C+1758))++and++to++observe++changes++in++the++histopathological++structure++of++the++kidneys%2C+including+damage+to+the+glomeruli+and+tubules.+To+induce+uric+acid+formation+in+mice%2C++chicken++liver++juice++and++potassium++oxonate++at++a++dose++of++250++mg%2Fkg++body+weight++were++used.++The++study++involved++24++male+BALB%2Fc++mice++aged++2%E2%80%933++months%2C+weighing++25%E2%80%9335++grams.++These++mice++were++divided++into++six++groups%3A++K0++(standard+feed+and+induced+with+only+1%25+CMC+Na)%2C+K%E2%88%92+(induced+with+1%25+CMC+Na)%2C+K%2B+(induced+with+allopurinol+at+10+mg%2Fkg+body+weight)%2C+and+treatment+groups+P1%2C+P2%2C+and+P3%2C+which+were+given+kersen+leaf+extract+at+doses+of+70+mg%2Fkg%2C+140+mg%2Fkg%2C+and+210+mg%2Fkg+body+weight%2C+respectively%2C+for+14+days.+Uric+acid+levels+were+measured+on+day+1+after+acclimatization%2C+day+8+after+potassium+oxonate+induction%2C+and+on+the+final+day+of+extract+administration%2C+day+23%2C+at+which+point+kidney+organs+were+also+collected.++The++results++showed++that++the++ethanolic++extract++of++kersen++leaves++could+reduce++uric++acid++levels++and++alleviate++damage++in++the++distal++convoluted++tubules%2C+proximal++convoluted++tubules%2C++and++glomeruli++of++hyperuricemic++mice.++The++P3+treatment+group+showed+the+highest+effectiveness%2C+which+is+attributed+to+its+higher+content++of++active++metabolites++compared++to++the++other++treatment++groups.++The+antihyperuricemic++compounds++found++in++kersen++leaves++include++flavonoids++and+saponins.+%0D%0AKeywords%3A+glomerulus%2C+kidney%2C+Muntingia+calabura%2C+potassium+oxonate%2C+tubule%2C+uric+acid.++&rft.publisher=FAKULTAS+MATEMATIKA+DAN+ILMU+PENGETAHUAN+ALAM+&rft.date=2025-05-26&rft.type=Skripsi&rft.type=NonPeerReviewed&rft.format=text&rft.identifier=http%3A%2F%2Fdigilib.unila.ac.id%2F88118%2F1%2FABSTRAK.pdf&rft.format=text&rft.identifier=http%3A%2F%2Fdigilib.unila.ac.id%2F88118%2F2%2FSKRIPSI%2520FULL.pdf&rft.format=text&rft.identifier=http%3A%2F%2Fdigilib.unila.ac.id%2F88118%2F3%2FSKRIPSI%2520TANPA%2520BAB%2520PEMBAHASAN.pdf&rft.identifier=++Yulia%2C+Rahmadina++(2025)+PENURUNAN+KADAR+ASAM+URAT+DAN+PERUBAHAN+STRUKTUR+HISTOPATOLOGI+GINJAL+PADA+MENCIT+(Mus+musculus+(Linnaeus%2C+1758))+SETELAH+PEMBERIAN+EKSTRAK+ETANOL+DAUN+KERSEN+(Muntingia+calabura+L.).++FAKULTAS+MATEMATIKA+DAN+ILMU+PENGETAHUAN+ALAM+%2C+UNIVERSITAS+LAMPUNG.+++++&rft.relation=http%3A%2F%2Fdigilib.unila.ac.id%2F88118%2F