?url_ver=Z39.88-2004&rft_id=2158011035+&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Adc&rft.title=+%0D%0AEFEK+EKSTRAK+ETANOL+BUAH+TAKOKAK+(Solanum+torvum+Sw.)%0D%0ATERHADAP+LUAS+PULAU+LANGERHANS+PANKREAS+TIKUS+%0D%0APUTIH+JANTAN+(Rattus+norvegicus)+MODEL+DIABETES%0D%0AMELITUS+%0D%0A+&rft.creator=M.Irsyad%2C++Nurullah+Aziz+&rft.subject=100+Filsafat+dan+psikologi&rft.subject=300+Ilmu+sosial&rft.subject=304+Faktor+yang+mempengaruhi+perilaku+sosial&rft.subject=610+Ilmu+kedokteran%2C+ilmu+pengobatan+dan+ilmu+kesehatan&rft.description=+%0D%0ABackground%3A+Takokak+fruit+contains+antioxidant+compounds+with+antidiabetic%0D%0Aproperties.+This+study+aims+to+determine+the+effect+of+administering+ethanol+extract%0D%0Aof+takokak+fruit+and+increasing+its+dosage+on+the+area+of+the+Langerhans+islets+in%0D%0Athe+pancreas+of+male+white+rats+with+a+diabetes+mellitus+model.%0D%0AMethods%3A+This+experimental+study+used+a+Post+Test+Only+Control+Group+Design%0D%0Awith+a+randomized+controlled+trial.+A+total+of+30+male+white+rats+were+divided+into%0D%0A5+groups%3A+the+KN+group+(no+treatment)%2C+the+K(-)+group+(induced+with+140+mg%2FKg%0D%0Abody+weight+of+alloxan)%2C+and+the+P1%2C+P2%2C+and+P3+groups+(induced+with+alloxan+140%0D%0Amg%2FKg+body+weight%2C+then+treated+with+ethanol+extract+of+takokak+fruit+at+doses+of%0D%0A100+mg%2FkgBW%2C+200+mg%2FkgBW%2C+and+400+mg%2FkgBW)+for+28+days.+Preparations+were%0D%0Aobserved+using+a+light+microscope+at+400x+magnification+in+5+fields+of+view%2C+then%0D%0Ameasured+using+the+ImageJ+application.%0D%0AResults%3A+The+average+area+of+the+islets+of+Langerhans+in+the+pancreas+of+male%0D%0Awhite+rats+was+as+follows%3A+KN+group%3A+0.018979+mm%C2%B2%2C+K(-)+group%3A+0.002328+mm%C2%B2%2C%0D%0AP1+group%3A+0.004873+mm%C2%B2%2C+P2+group%3A+0.007529+mm%C2%B2%2C+and+P3+group%3A+0.008585+mm%C2%B2.%0D%0ASignificant+differences+in+the+average+area+were+found+between+the+KN+group+and%0D%0Athe+K(-)+and+P1+groups%3B+between+the+K(-)+group+and+the+P1%2C+P2%2C+and+P3+groups%3B%0D%0Aand+between+the+P1+and+P3+groups.%0D%0AConclusion%3A+There+is+an+effect+of+ethanol+extract+of+takokak+fruit+on+the+area+of%0D%0Athe+islets+of+Langerhans+in+the+pancreas+of+male+white+rats+with+a+diabetes+mellitus%0D%0Amodel.+There+is+an+effect+of+increased+doses+of+ethanol+extract+of+takokak+fruit+on%0D%0Athe+area+of+the+islets+of+Langerhans+in+the+pancreas+of+male+white+rats+with+a%0D%0Adiabetes+mellitus+model%2C+with+the+most+significant+dose+being+400+mg%2Fkg+body%0D%0Aweight.%0D%0A%0D%0AKeywords%3A+alloxan%2C+diabetes+mellitus%2C+pancreas%2C+Solanum+torvum+%0D%0ALatar+Belakang%3A+Buah+takokak+mengandung+senyawa+antioksidan+sebagai+anti%0D%0Adiabetes.+Penelitian+ini+bertujuan+untuk+mengetahui+pengaruh+pemberian+ekstrak%0D%0Aetanol+buah+takokak+dan+peningkatan+dosisnya+terhadap+luas+pulau+Langerhans%0D%0Apankreas+tikus+putih+jantan+model+diabetes+melitus.%0D%0AMetode%3A+Penelitian+eksperimental+ini+menggunakan+metode+rancangan+acak%0D%0Aterkontrol+Post+Test+Only+Control+Group+Design.+Sebanyak+30+ekor+tikus+putih%0D%0Ajantan+dibagi+menjadi+5+kelompok%3A+kelompok+KN+sebagai+tikus+tanpa+perlakuan%3B%0D%0Akelompok+K(-)+yang+diinduksi+aloksan+140+mg%2FKgBB%3B+kelompok+P1%2C+P2%2C+dan+P3%0D%0Ayang+diinduksi+aloksan+140+mg%2FKgBB%2C+kemudian+diberi+ekstrak+etanol+buah%0D%0Atakokak+dengan+dosis+berbeda+(100+mg%2FkgBB%2C+200+mg%2FkgBB%2C+dan+400+mg%2FkgBB)%0D%0Aselama+28+hari.+Pengamatan+preparat+menggunakan+mikroskop+cahaya+dengan%0D%0Aperbesaran+400x+dalam+5+lapang+pandang+kemudian+diukur+menggunakan+aplikasi%0D%0AImageJ.%0D%0AHasil%3A+Didapatkan+rerata+luas+pulau+Langerhans+pankreas+tikus+putih+jantan+%0D%0Akelompok+KN%3A+0%2C018979+mm%0D%0A2%0D%0A%2C+K(-)%3A+0%2C002328+mm%0D%0A2%0D%0A%2C+P1%3A+0%2C004873+mm%0D%0A2%0D%0A%2C+P2%3A%0D%0A0%2C007529+mm%0D%0A2%0D%0A%2C+dan+P3%3A+0%2C008585+mm%0D%0A2%0D%0A.+Didapatkan+perbedaan+rerata+yang%0D%0Asignifikan+antara+kelompok+KN+dengan+K(-)+dan+P1%3B+kelompok+K(-)+dengan+P1%2C%0D%0AP2%2C+dan+P3%3B+dan+P1+dengan+P3.%0D%0ASimpulan%3A+Terdapat+pengaruh+dari+pemberian+ekstrak+etanol+buah+takokak%0D%0Aterhadap+luas+pulau+Langerhans+pankreas+tikus+putih+jantan+model+diabetes%0D%0Amelitus.+Terdapat+pengaruh+dari+peningkatan+dosis+ekstrak+etanol+buah+takokak%0D%0Aterhadap+luas+pulau+Langerhans+pankreas+tikus+putih+jantan+model+diabetes%0D%0Amelitus%2C+dengan+dosis+yang+paling+berpengaruh+adalah+400+mg%2FkgBB.%0D%0A%0D%0AKata+Kunci%3A+aloksan%2C+diabetes+melitus%2C+pankreas%2C+Solanum+torvum&rft.publisher=KEDOKTERAN&rft.date=2025-05-07&rft.type=Skripsi&rft.type=NonPeerReviewed&rft.format=text&rft.identifier=http%3A%2F%2Fdigilib.unila.ac.id%2F88163%2F1%2FABSTRAK.pdf&rft.format=text&rft.identifier=http%3A%2F%2Fdigilib.unila.ac.id%2F88163%2F2%2FSKRIPSI%2520FULL.pdf&rft.format=text&rft.identifier=http%3A%2F%2Fdigilib.unila.ac.id%2F88163%2F3%2FSKRIPSI%2520FULL%2520TANPA%2520BAB%2520PEMBAHASAN.pdf&rft.identifier=++M.Irsyad%2C+Nurullah+Aziz+++(2025)++EFEK+EKSTRAK+ETANOL+BUAH+TAKOKAK+(Solanum+torvum+Sw.)+TERHADAP+LUAS+PULAU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