?url_ver=Z39.88-2004&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Adc&rft.title=UJI+AKTIVITAS+ANTIDIABETES+EKSTRAK+DAUN+ISEM++%0D%0AKUMBANG+(Mangifera+Quadrifida+Jack)+PADA+MENCIT+(Mus%0D%0AMusculus)+YANG+DIINDUKSI+ALOKSAN%0D%0A&rft.creator=Agnes+Monica+%2C+Murisla&rft.subject=610+Ilmu+kedokteran%2C+ilmu+pengobatan+dan+ilmu+kesehatan&rft.description=Latar+Belakang+%3A+Diabetes+melitus+merupakan+penyakit+kronis+yang+prevalensinya%0D%0Aterus+meningkat+di+Indonesia.+Pengobatan+konvensional+seperti+obat%0D%0Aantihiperglikemia+oral+seringkali+menimbulkan+efek+samping%2C+sehingga+diperlukan%0D%0Aalternatif+pengobatan+bahan+alam.+Daun+Isem+Kumbang+(Mangifera+quadrifida%0D%0AJack.)+diketahui+mengandung+senyawa+bioaktif+yang+berpotensi+sebagai%0D%0Aantidiabetes.%0D%0AMetode+%3A+Penelitian+ini+merupakan+eksperimental+menggunakan+mencit+(Mus%0D%0Amusculus)+yang+diinduksi+aloksan+untuk+menciptakan+kondisi+diabetes.+Hewan+uji%0D%0Adibagi+menjadi+lima+kelompok%3A+kontrol+negatif%2C+kontrol+positif+(glimepirid)%2C+dan+tiga%0D%0Akelompok+perlakuan+yaitu%2C+dosis+ekstrak+125+mg%2FkgBB%2C+250+mg%2FkgBB%2C+dan+500%0D%0Amg%2FkgBB.+Kadar+glukosa+darah+diukur+pada+hari+ke-0%2C+3%2C+5%2C+dan+7+menggunakan%0D%0Aalat+glukometer.%0D%0AHasil+%3A+Hasil+penelitian+menunjukkan+bahwa+ekstrak+daun+isem+kumbang+memiliki%0D%0Aefek+antidiabetes+terhadap+mencit+yang+diinduksi+aloksan.+Kelompok+perlakuan+1%0D%0A(125+mg%2FkgBB)+mengalami+penurunan+kadar+glukosa+darah+sebesar+218%2C25+mg%2Fdl.%0D%0AKelompok+perlakuan+2+(250+mg%2FkgBB)+mengalami+penurunan+sebesar+235+mg%2Fdl.%0D%0AKelompok+perlakuan+3+(500+mg%2FkgBB)+menunjukkan+penurunan+paling+besar%2C+yaitu%0D%0Asebesar+289%2C25+mg%2Fdl%2C+namun+belum+sebanding+dengan+kontrol+positif%0D%0A(glimepiride).%0D%0AKesimpulan+%3A+Ekstrak+daun+Isem+Kumbang+memiliki+efek+antidiabetes+yang%0D%0Asignifikan+pada+mencit+diabetes+dengan+penurunan+sebesar+289%2C25+mg%2Fdl+dan+dosis%0D%0A500+mg%2FkgBB+sebagai+dosis+terbaik+diantara+ketiga+dosis+lainnya.%0D%0A%0D%0AKata+Kunci+%3A+Diabetes+melitus%2C+Antidiabetes%2C+Mangifera+quadrifida+Jack+%0D%0A+%0D%0ABackground%3A+Diabetes+mellitus+is+a+chronic+disease+whose+prevalence+continues+to%0D%0Aincrease+in+Indonesia.+Conventional+treatments+such+as+insulin+and+oral%0D%0Aantihyperglycemic+drugs+often+cause+side+effects%2C+so+alternative+natural+treatments%0D%0Aare+needed.+Isem+Kumbang+leaves+(Mangifera+quadrifida+Jack.)+are+known+to%0D%0Acontain+bioactive+compounds+that+have+the+potential+to+be+antidiabetic.%0D%0AMethods%3A+This+study+was+an+experimental+study+using+mice+(Mus+musculus)%0D%0Ainduced+by+alloxan+to+create+diabetic+conditions.+The+test+animals+were+divided+into%0D%0Afive+groups%3A+negative+control%2C+positive+control+(glimepiride)%2C+and+three+treatment%0D%0Agroups%2C+namely%2C+extract+doses+of+125+mg%2FkgBW%2C+250+mg%2FkgBW%2C+and+500%0D%0Amg%2FkgBW.+Blood+glucose+levels+were+measured+on+days+0%2C+3%2C+5%2C+and+7+using+a%0D%0Aglucometer.%0D%0AResults%3A+The+results+showed+that+the+extract+of+isem+jenggot+leaves+has+an%0D%0Aantidiabetic+effect+on+mice+induced+by+alloxan.+Treatment+group+1+(125+mg%2FkgBW)%0D%0Aexperienced+a+decrease+in+blood+glucose+levels+of+218.25+mg%2Fdl.+Treatment+group+2%0D%0A(250+mg%2FkgBW)+experienced+a+decrease+of+235+mg%2Fdl.+Treatment+group+3+(500%0D%0Amg%2FkgBW)+showed+the+greatest+decrease%2C+which+was+289.25+mg%2Fdl%2C+but+was+not%0D%0Acomparable+to+the+positive+control+(glimepiride).%0D%0AConclusion%3A+Isem+Kumbang+leaf+extract+has+a+significant+antidiabetic+effect+on%0D%0Adiabetic+mice+with+a+decrease+of+289.25+mg%2Fdl+and+a+dose+of+500+mg%2FkgBW+as+the%0D%0Abest+dose+among+the+other+three+doses.%0D%0A%0D%0AKeywords%3A+Diabetes+mellitus%2C+Antidiabetic%2C+Mangifera+quadrifida+Jack+%0D%0A&rft.publisher=FAKULTAS+KEDOKTERAN&rft.date=2025-05-23&rft.type=Skripsi&rft.type=NonPeerReviewed&rft.format=text&rft.identifier=http%3A%2F%2Fdigilib.unila.ac.id%2F88803%2F1%2FABSTRAK.pdf&rft.format=text&rft.identifier=http%3A%2F%2Fdigilib.unila.ac.id%2F88803%2F4%2FSKRIPSI%2520FULL%2520TANPA%2520LAMPIRANN.pdf&rft.format=text&rft.identifier=http%3A%2F%2Fdigilib.unila.ac.id%2F88803%2F5%2FSKRIPSI%2520FULL%2520TANPA%2520PEMBAHASAN.pdf&rft.identifier=++Agnes+Monica+%2C+Murisla++(2025)+UJI+AKTIVITAS+ANTIDIABETES+EKSTRAK+DAUN+ISEM+KUMBANG+(Mangifera+Quadrifida+Jack)+PADA+MENCIT+(Mus+Musculus)+YANG+DIINDUKSI+ALOKSAN.++FAKULTAS+KEDOKTERAN%2C+UNIVERSITAS+LAMPUNG.+++++&rft.relation=http%3A%2F%2Fdigilib.unila.ac.id%2F88803%2F