?url_ver=Z39.88-2004&rft_id=2157061002&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Adc&rft.title=ANALISIS+STATUS+METILASI+GEN+SEPTIN9+DAN+ZNF671+DALAM+SAMPEL+SALIVA+SEBAGAI+BIOMARKER+POTENSIAL+UNTUK+DETEKSI+DINI+KANKER+NASOFARING&rft.creator=GHINA+AUFA+%2C+FATHINA+AZHAR&rft.subject=500+ilmu+pengetahuan+alam+dan+matematika&rft.subject=570+Biologi&rft.description=Kanker+nasofaring+(NPC)+yang+berhubungan+dengan+infeksi+Epstein-Barr+Virus+(EBV)+sering+terdiagnosis+pada+stadium+lanjut+karena+lokasi+nasofaring+yang+sulit+dijangkau.+Oleh+karena+itu%2C+deteksi+dini+berbasis+metode+non-invasif+menjadi+sangat+penting.+Penelitian+ini+bertujuan+menganalisis+status+metilasi+gen+SEPTIN9+dan+ZNF671+dalam+saliva+sebagai+biomarker+potensial+untuk+deteksi+dini+NPC.+Sampel+terdiri+dari+20+subjek+sehat+(10+EBV+positif%2C+10+EBV+negatif)%2C+10+pasien+NPC+EBV+positif%2C+serta+sel+RAJI+sebagai+kontrol+positif.+Deteksi+metilasi+dilakukan+menggunakan+metode+Methylation+Sensitive+Restriction+Enzyme+PCR+(PCR-MSRE)+dengan+enzim+HpaII+dan+MspI.+Uji+normalitas+dilakukan+dengan+Shapiro-Wilk%2C+sedangkan+perbandingan+antar+kelompok+dianalisis+menggunakan+uji+Mann-Whitney.+Hasil+menunjukkan+tidak+ada+perbedaan+signifikan+pada+status+metilasi+antar+kelompok+(p%3E0%2C05).+Meskipun+demikian%2C+penelitian+ini+menunjukkan+bahwa+saliva+berpotensi+digunakan+sebagai+sampel+non-invasif+untuk+mendeteksi+metilasi+DNA+pada+gen+target+terkait+NPC.%0D%0A%0D%0AKata+Kunci%3A+Epstein-Barr+Virus%2C+Metilasi+DNA%2C+PCR+MSRE%0D%0A%0D%0A%0D%0A%0D%0A%0D%0A%0D%0A%0D%0Aabstract%0D%0A%0D%0ANasopharyngeal+carcinoma+(NPC)%2C+commonly+associated+with+Epstein-Barr+Virus+(EBV)+infection%2C+is+often+diagnosed+at+an+advanced+stage+due+to+the+anatomically+inaccessible+location+of+the+nasopharynx.+Therefore%2C+early+detection+through+non-invasive+methods+is+crucial.+This+study+aimed+to+evaluate+the+methylation+status+of+the+SEPTIN9+and+ZNF671+genes+in+saliva+as+potential+biomarkers+for+early+NPC+detection.+Samples+were+collected+from+20+healthy+individuals+(10+EBV-positive+and+10+EBV-negative)%2C+10+EBV-positive+NPC+patients%2C+and+RAJI+cells+as+a+positive+control.+DNA+methylation+was+assessed+using+the+Methylation+Sensitive+Restriction+Enzyme+PCR+(MSRE+PCR)+method+with+HpaII+and+MspI+enzymes.+Normality+was+tested+using+the+Shapiro-Wilk+test%2C+and+group+comparisons+were+performed+using+the+Mann-Whitney+U+test.+The+results+showed+no+statistically+significant+differences+in+methylation+status+between+groups+(p+%3E+0.05).+Although+not+statistically+significant%2C+the+findings+suggest+that+saliva+is+a+feasible+non-invasive+sample+for+detecting+DNA+methylation+in+target+genes+associated+with+NPC.%0D%0A%0D%0AKeywords%3A+Epstein-Barr+Virus%2C+DNA+Methylation%2C+MSRE-PCR&rft.publisher=FAKULTAS+MATEMATIKA+DAN+ILMU+PENGETAHUAN+ALAM&rft.date=2025-06-12&rft.type=Skripsi&rft.type=NonPeerReviewed&rft.format=text&rft.identifier=http%3A%2F%2Fdigilib.unila.ac.id%2F88948%2F1%2FABSTRAK.pdf&rft.format=text&rft.identifier=http%3A%2F%2Fdigilib.unila.ac.id%2F88948%2F2%2FSKRIPSI%2520FULL.pdf&rft.format=text&rft.identifier=http%3A%2F%2Fdigilib.unila.ac.id%2F88948%2F3%2FSKRIPSI%2520TANPA%2520BAB%2520PEMBAHASAN.pdf&rft.identifier=++GHINA+AUFA+%2C+FATHINA+AZHAR++(2025)+ANALISIS+STATUS+METILASI+GEN+SEPTIN9+DAN+ZNF671+DALAM+SAMPEL+SALIVA+SEBAGAI+BIOMARKER+POTENSIAL+UNTUK+DETEKSI+DINI+KANKER+NASOFARING.++FAKULTAS+MATEMATIKA+DAN+ILMU+PENGETAHUAN+ALAM%2C+UNIVERITAS+LAMPUNG.+++++&rft.relation=http%3A%2F%2Fdigilib.unila.ac.id%2F88948%2F