@misc{eprints88957,
           month = {Mei},
           title = {
 
IDENTIFIKASI FAKTOR RISIKO PENYEBAB KEGAGALAN TERAPI
ANTIRETROVIRAL PADA PASIEN ANAK PENGIDAP HIV DI RSUD  
Dr. H. ABDUL MOELOEK BANDAR LAMPUNG TAHUN 2024
 },
          author = {FADHLI JONIS MOHAMAD},
         address = {UNIVERSITAS LAMPUNG},
       publisher = {FAKULTAS KEDOKTERAN},
            year = {2025},
             url = {http://digilib.unila.ac.id/88957/},
        abstract = {Background: Human Immunodeficiency Virus (HIV) is an infection that causes a 
decline in the immune system, making the body more vulnerable to diseases. The
World Health Organization (WHO) recommends viral load (VL) testing using a
cutoff point of 1000 copiesRNA/ml to assess the effectiveness of antiretroviral
(ARV) therapy. The aim of this study is to identify the risk factors for ARV therapy
failure in children diagnosed with HIV at Dr. H. Abdul Moeloek General Hospital,
Bandar Lampung, in 2024.
Methods: This study used a cross-sectional design with data collected from medical
records and a medication adherence questionnaire. The study was conducted at Dr.
H. Abdul Moeloek Regional General Hospital from July to December 2024. The
research sample consisted of all children living with HIV who received treatment
at the VCT clinic of Dr. H. Abdul Moeloek Regional General Hospital in 2024,
totaling 50 samples. Bivariate statistical analysis was performed using the ChiSquare
test
with
Fisher's
alternative,
and
multivariate
analysis
was
conducted
using

logistic
regression.

Results:

In this study, 6 (12\%) out of 50 samples experienced virological therapy
failure. There was a significant association with medication adherence (p-value=
0.000), while no association was found with the clinical stage of HIV at diagnosis
(p-value= 0.575), age at diagnosis (p-value= 0.069), and nutritional status (p-value=
0.201). Multivariate analysis showed that medication adherence was the most
significant factor (p-value = 0.003; OR = 20.000).
Conclusion: Noncompliance with medication is a risk factor for antiretroviral
therapy failure in children with HIV.

Keywords: Viral load, HIV, Children

 Latar Belakang: Human Immunodeficiency Virus (HIV) merupakan infeksi yang 
menyebabkan sistem kekebalan tubuh menurun sehingga rentan terhadap penyakit.
World Health Organization (WHO) merekomendasikan pemeriksaan viral load
(VL) menggunakan cut off point 1000 copiesRNA/ml untuk melihat keberhasilan
terapi antiretroviral (ARV). Penelitian ini bertujuan untuk mengidentifikasi faktor
risiko kegagalan terapi ARV pada anak yang terdiagnosis HIV di RSUD Dr. H.
Abdul Moeloek Bandar Lampung pada tahun 2024. 
Metode: Penelitian ini menggunakan desain cross sectional dengan pengambilan
data mengunakan rekam medis dan kuesioner kepatuhan minum obat. Penelitian ini
dilakukan di RSUD Dr. H. Abdul Moeloek pada bulan Juli ? Desember 2024.
Sampel penelitian terdiri dari seluruh anak pengidap HIV yang berobat di poli VCT
RSUD Dr. H. Abdul Moeloek pada tahun 2024 berjumlah 50 sampel. Uji statistik
bivariat mengunakan Chi-Square dengan alternatif fisher dan uji statistik
multivariat dengan uji regresi logistik
Hasil dan Pembahasan: Pada penelitian ini, 6 (12\%) dari 50 sampel mengalami
gagal terapi virologi. Terdapat hubungan antara kepatuhan minum obat (pvalue=0,000)
sedangkan
stadium
klinis
HIV
saat
terdiagnosis
(p-value=0,575),
usia

saat

terdiagnosis (p-value=0,069), dan status gizi (p-value=0,201) tidak terdapat
hubungan. Hasil multivariat didapatkan kepatuhan minum obat merupakan faktor
terbesar (p-value= 0,003; OR= 20,000)
Simpulan: Ketidakpatuhan minum obat merupakan faktor risiko kejadian gagal
terapi antiretroviral pada pasien anak pengidap HIV.

Kata Kunci: Viral load, HIV, Anak

 }
}