?url_ver=Z39.88-2004&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Adc&rft.title=SINTESIS+DAN+KARAKTERISASI+SERTA+UJI+PENDAHULUAN%0D%0AAKTIVITAS+ANTIKANKER+BEBERAPA+SENYAWA%0D%0AORGANOTIMAH(IV)+4-NITROBENZOAT%0D%0ATERHADAP+SEL+LEUKEMIA+L-1210+(SYNTHESIS%2C+CHARACTERIZATION+AND+PRELIMINARY%0D%0AANTICANCER+ACTIVITY+TEST+OF+SOME%0D%0AORGANOTIN(IV)+4-NITROBENZOATES%0D%0AAGAINST+LEUKEMIA+CELLS+L-1210)&rft.creator=Arpan%2C+Sherly+Nurimani&rft.subject=Q+Science+(General)&rft.subject=QD+Chemistry&rft.description=Pada+penelitian+ini%2C+telah+dilakukan+sintesis+senyawa+dibutiltimah(IV)+di-4-%0D%0Anitrobenzoat%2C+difeniltimah(IV)+di-4-nitrobenzoat+dan+trifeniltimah(IV)+4-%0D%0Anitrobenzoat+melalui+dua+tahap.+Tahap+pertama+yaitu+pembentukan+senyawa%0D%0Aantara+organotimah(IV)+hidroksida+atau+oksida+dari+organotimah(IV)+klorida+dan%0D%0ANaOH%2C+kemudian+direaksikan+dengan+asam+4-nitrobenzoat+untuk+menghasilkan%0D%0Asenyawa+akhir.+Dari+hasil+sintesis+diperoleh+produk+berupa+padatan+berwarna%0D%0Aputih+dengan+rendemen+87%2C27%3B+88%2C33%2C+dan+86%2C53+%25+untuk+masing-masing+senyawa%0D%0Adibutiltimah(IV)+di-4-nitrobenzoat%2C+difeniltimah(IV)+di-4-nitrobebzoat+dan%0D%0Atrifeniltimah(IV)+4-nitrobenzoat+dengan+waktu+refluks+optimum+4+jam.%0D%0ASenyawa+awal+dan+senyawa+hasil+sintesis+dikarakterisasi+dengan+menggunakan%0D%0Aspektrofotometer+IR+dan+UV+untuk+melihat+gugus+fungsi+dan+%CE%BBmax+yang+terdapat%0D%0Apada+senyawa.+Selain+itu+dilakukan+juga+analisis+unsur+dengan+menggunakan%0D%0Amicroelemental+analyzer+terhadap+senyawa+hasil+sintesis.+Berdasarkan+data+hasil%0D%0Amikroanalisis%2C+senyawa+yang+diperoleh+telah+murni+karena+perbedaan+data+yang%0D%0Adiperoleh+dengan+perhitungan+secara+teori+masih+berkisar+1-5%25.+Uji+pendahuluan%0D%0Aaktivitas+antikanker+terhadap+sel+leukemia+L-1210+diperoleh+nilai+IC50+untuk%0D%0Asenyawa+dibutiltimah(IV)+di-4-nitrobenzoat%2C+difeniltimah(IV)+di-4-nitrobenzoat%0D%0Adan+trifeniltimah(IV)+4-nitrobenzoat+beturut-turut+adalah+18%2C8%3B+8%2C8%3B+dan+2%2C27%0D%0A%CE%BCg%2FmL.+(In+this+study%2C+it+was+performed+the+synthesis+of+dibutyltin(IV)+di-4-nitrobenzoate%2C%0D%0Adiphenyltin(IV)+di-4-nitrobenzoate+and+triphenyltin(IV)+4-nitrobenzoate%0D%0Acompounds+through+two-step+reactions.+The+first+step+was+the+formation+of+the%0D%0Aorganotin(IV)+hydroxide+or+oxide+by+reacting+the+organotin(IV)+chloride+and%0D%0ANaOH%2C+then+reacting+the+organotin(IV)+hydroxide+or+oxide+with+4-nitrobenzoic%0D%0Aacid+to+produce+the+final+compound.+The+results+of+synthesis+were+in+the+form+of%0D%0Awhite+solid+with+percent+yield+for+dibutyltin(IV)+di-4-nitrobenzoate%2C%0D%0Adiphenyltin(IV)+di-4-nitrobenzoate+and+triphenyltin(IV)+4-nitrobenzoate+of+87.27%3B%0D%0A88.33%2C+and+86.53%25%2C+respectively+with+optimum+reflux+time+of+4+hours.%0D%0AThe+initial+compounds+and+the+compounds+synthesized+were+characterized+using%0D%0AIR+and+UV+spectrophotometer+to+identify+the+functional+group+and+%CE%BBmax+contained%0D%0Ain+the+compound.+Furthermore%2C+microelemental+analysis+was+also+done+using+the%0D%0Amicroelemental+analyzer+to+compounds+synthesized.+Based+on+the+data+from%0D%0Amicroanalysis%2C+the+compounds+obtained+were+quite+pure+as+the+differences+in+data%0D%0Aobtained+compared+to+the+theoretical+calculations+of+in+the+range+of+1-5%25.+The%0D%0AIC50+values+obtained+from+preliminary+anticancer+activity+against+leukemia+cells%0D%0AL-1210+for+dibutyltin(IV)+di-4-nitrobenzoate%2C+diphenyltin(IV)+di-4-nitrobenzoate%0D%0Aand+triphenyltin(IV)+4-nitrobenzoate+were+18.8%3B+8.8%2C+and+2.27+%CE%BCg%2FmL%2C%0D%0Arespectively.)&rft.publisher=Fakultas+MIPA&rft.date=2013-09-23&rft.type=Skripsi&rft.type=NonPeerReviewed&rft.format=text&rft.identifier=http%3A%2F%2Fdigilib.unila.ac.id%2F911%2F1%2FCover%2520Dalam.pdf&rft.format=text&rft.identifier=http%3A%2F%2Fdigilib.unila.ac.id%2F911%2F2%2FAbstract.pdf&rft.format=text&rft.identifier=http%3A%2F%2Fdigilib.unila.ac.id%2F911%2F3%2FAbstrak.pdf&rft.format=text&rft.identifier=http%3A%2F%2Fdigilib.unila.ac.id%2F911%2F4%2FHal.%2520Pengesahan.pdf&rft.format=text&rft.identifier=http%3A%2F%2Fdigilib.unila.ac.id%2F911%2F5%2FHal.%2520Persetujuan.pdf&rft.format=text&rft.identifier=http%3A%2F%2Fdigilib.unila.ac.id%2F911%2F6%2FDaftar%2520isi.pdf&rft.format=text&rft.identifier=http%3A%2F%2Fdigilib.unila.ac.id%2F911%2F7%2FBab%25201.pdf&rft.format=text&rft.identifier=http%3A%2F%2Fdigilib.unila.ac.id%2F911%2F8%2FBab%25202.pdf&rft.format=text&rft.identifier=http%3A%2F%2Fdigilib.unila.ac.id%2F911%2F9%2FBab%25203.pdf&rft.format=text&rft.identifier=http%3A%2F%2Fdigilib.unila.ac.id%2F911%2F10%2FBab%25204.pdf&rft.format=text&rft.identifier=http%3A%2F%2Fdigilib.unila.ac.id%2F911%2F11%2FBab%25205.pdf&rft.format=text&rft.identifier=http%3A%2F%2Fdigilib.unila.ac.id%2F911%2F12%2FDaftar%2520Pustaka.pdf&rft.format=archive&rft.identifier=http%3A%2F%2Fdigilib.unila.ac.id%2F911%2F13%2FLAMPIRAN.zip&rft.identifier=++Arpan%2C+Sherly+Nurimani++(2013)+SINTESIS+DAN+KARAKTERISASI+SERTA+UJI+PENDAHULUAN+AKTIVITAS+ANTIKANKER+BEBERAPA+SENYAWA+ORGAN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