Prianggara Rostu Prayoga, 1118011100 (2015) PENGARUH PAPARAN GELOMBANG ELEKTROMAGNETIK KRONIK TERHADAP MEMORI KERJA DAN PERUBAHAN PERILAKU PADA TIKUS PUTIH (Rattus novergicus) GALUR Sprague dawley. Fakultas Kedokteran, Universitas Lampung.
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Abstrak (Berisi Bastraknya saja, Judul dan Nama Tidak Boleh di Masukan)
ABSTRACT THE EFFECT OF CHRONIC ELECTROMAGNETICS WAVE EXPOSURES TO WORKING MEMORY AND BEHAVIORAL CHANGES IN WHITE RATS (Rattus novergicus) Sprague dawley STRAIN BY PRIANGGARA ROSTU PRAYOGA The high rate of mobile phone use in the community will increase the exposure to electromagnetic waves. Exposure to electromagnetic waves can increase the activity of oxidation and free radicals that can alter the body's physiology. This is due to the presence of reactive oxygen species (ROS) and the induction of oxidative stress that has an effect on cell damage, especially in brain tissue. The stress induction also affect on memory, chronic stress will cause a deficit in working memory which indicates damage on the hippocampus. Damage to the hippocampus as a result of chronic stress can also can lead to changes in behavior. The purpose of this study is to determine the effect of mobile phone electromagnetic exposure to working memory and sucrose intake. The sample of this research are 18 rats (Rattus norvegicus) 2-3 week-old Sprague dawley strain were divided into 3 different groups: control group (K), 1 hour exposure per day group (P1) and 3 hours exposure per day (P2) which exposed to mobile phone’s electromagnetic waves for 21 days. Pre-test and post-test of working memory are done with Radial Arm Maze. Pre-test was performed 1 day before treatment and post-test performed on the day 22. Sucrose intake measurements performed daily until day 21 of exposure. The average values of working memory’s pre-test are K:3,83%, P1:3,67%, P2:3,83% and for the post-test are K:1,83%, P1:1,67%, P2:1,33% with Wilcoxon bivariate analysis test in K p=0,026, P1 p=0,026, P2 p= 0,026 (p< 0,05). The average of sucrose intake are K:181,19ml, P1:159,05ml, P2:171,19ml with p=0,311 (p> 0,05) in Kruskal-Wallis bivariate analysis test. Chronic exposure to phone’s electromagnetic waves for 21 days impressed the working memory and not affected sucrose intake in rats (Rattus norvegicus). Keywords: electromagnetic waves, mobile phones, sucrose intake, working memory, reactive oxygen species. ABSTRAK PENGARUH PAPARAN GELOMBANG ELEKTROMAGNETIK KRONIK TERHADAP MEMORI KERJA DAN PERUBAHAN PERILAKU PADA TIKUS PUTIH (Rattus novergicus) GALUR Sprague dawley OLEH PRIANGGARA ROSTU PRAYOGA Semakin tingginya tingkat penggunaan handphone di masyarakat akan meningkatkan paparan terhadap gelombang elektromagnetik. Paparan gelombang elektromagnetik dapat menyebabkan gangguan fisiologi tubuh. Hal ini akibat adanya reactive oxygen species (ROS) dan induksi stres oksidatif memiliki efek pada kerusakan sel terutama di jaringan otak. Induksi stres ini berpengaruh pada memori, yaitu defisit dalam memori kerja yang menandakan kerusakan dari hippocampus. Kerusakan hippocampus akibat stres kronik juga dapat menyebabkan perubahan perilaku. Untuk mengetahui pengaruh paparan elektromagnetik handphone terhadap memori kerja dan intake sukrosa. Pada penelitian ini 18 ekor tikus putih (Rattus norvegicus) galur Sprague dawley berusia 2-3 minggu dibagi ke dalam 3 kelompok, yaitu kelompok kontrol (K), kelompok perlakuan 1 jam/hari (P1) dan kelompok perlakuan 3 jam/hari (P2) dipaparkan dengan gelombang elektromagnetik handphone selama 21 hari. Pengujian memori kerja pre-test dan post-test menggunakan radial arm maze. Pre-test dilakukan 1 hari sebelum perlakuan dan post-test dilakukan dihari ke-22. Pengukuran intake sukrosa dilakukan setiap hari sampai paparan hari ke-21. Hasil rerata pre-test memori kerja pada K:3,83%, P1:3,67%, P2:3,83% dan post-test memori kerja pada K:1,83%, P1:1,67%, P2:1,33% dengan hasil analisis bivariat Wilcoxon untuk K p= 0,026, P1 p= 0,026 dan P2 p= 0,024 (p< 0,05). Hasil rerata intake sukrosa pada K:181,19ml, P1:159,05ml, P2:171,19ml dengan hasil analisis bivariat Kruskal-Wallis p=0,311 (p> 0,05). Paparan gelombang elektromagnetik handphone dalam periode kronik selama 21 hari berpengaruh terhadap memori kerja dan tidak berpengaruh terhadap intake sukrosa pada tikus putih (Rattus norvegicus). Kata kunci: Gelombang elektromagnetik, handphone, intake sukrosa, memori kerja, reactive oxygen species.
| Jenis Karya Akhir: | Skripsi |
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| Subyek: | |
| Program Studi: | Fakultas Kedokteran > Prodi Pendidikan Dokter |
| Pengguna Deposit: | 7929087 . Digilib |
| Date Deposited: | 04 Feb 2015 08:04 |
| Terakhir diubah: | 04 Feb 2015 08:04 |
| URI: | http://digilib.unila.ac.id/id/eprint/6845 |
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