SINTESIS DAN KARAKTERISASI SERTA UJI PENDAHULUAN AKTIVITAS ANTIKANKER BEBERAPA SENYAWA ORGANOTIMAH(IV) 4-NITROBENZOAT TERHADAP SEL LEUKEMIA L-1210 (SYNTHESIS, CHARACTERIZATION AND PRELIMINARY ANTICANCER ACTIVITY TEST OF SOME ORGANOTIN(IV) 4-NITROBENZOATES AGAINST LEUKEMIA CELLS L-1210)

Arpan, Sherly Nurimani (2013) SINTESIS DAN KARAKTERISASI SERTA UJI PENDAHULUAN AKTIVITAS ANTIKANKER BEBERAPA SENYAWA ORGANOTIMAH(IV) 4-NITROBENZOAT TERHADAP SEL LEUKEMIA L-1210 (SYNTHESIS, CHARACTERIZATION AND PRELIMINARY ANTICANCER ACTIVITY TEST OF SOME ORGANOTIN(IV) 4-NITROBENZOATES AGAINST LEUKEMIA CELLS L-1210). Fakultas MIPA, Universitas Lampung.

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Abstrak

Pada penelitian ini, telah dilakukan sintesis senyawa dibutiltimah(IV) di-4- nitrobenzoat, difeniltimah(IV) di-4-nitrobenzoat dan trifeniltimah(IV) 4- nitrobenzoat melalui dua tahap. Tahap pertama yaitu pembentukan senyawa antara organotimah(IV) hidroksida atau oksida dari organotimah(IV) klorida dan NaOH, kemudian direaksikan dengan asam 4-nitrobenzoat untuk menghasilkan senyawa akhir. Dari hasil sintesis diperoleh produk berupa padatan berwarna putih dengan rendemen 87,27; 88,33, dan 86,53 % untuk masing-masing senyawa dibutiltimah(IV) di-4-nitrobenzoat, difeniltimah(IV) di-4-nitrobebzoat dan trifeniltimah(IV) 4-nitrobenzoat dengan waktu refluks optimum 4 jam. Senyawa awal dan senyawa hasil sintesis dikarakterisasi dengan menggunakan spektrofotometer IR dan UV untuk melihat gugus fungsi dan λmax yang terdapat pada senyawa. Selain itu dilakukan juga analisis unsur dengan menggunakan microelemental analyzer terhadap senyawa hasil sintesis. Berdasarkan data hasil mikroanalisis, senyawa yang diperoleh telah murni karena perbedaan data yang diperoleh dengan perhitungan secara teori masih berkisar 1-5%. Uji pendahuluan aktivitas antikanker terhadap sel leukemia L-1210 diperoleh nilai IC50 untuk senyawa dibutiltimah(IV) di-4-nitrobenzoat, difeniltimah(IV) di-4-nitrobenzoat dan trifeniltimah(IV) 4-nitrobenzoat beturut-turut adalah 18,8; 8,8; dan 2,27 μg/mL. (In this study, it was performed the synthesis of dibutyltin(IV) di-4-nitrobenzoate, diphenyltin(IV) di-4-nitrobenzoate and triphenyltin(IV) 4-nitrobenzoate compounds through two-step reactions. The first step was the formation of the organotin(IV) hydroxide or oxide by reacting the organotin(IV) chloride and NaOH, then reacting the organotin(IV) hydroxide or oxide with 4-nitrobenzoic acid to produce the final compound. The results of synthesis were in the form of white solid with percent yield for dibutyltin(IV) di-4-nitrobenzoate, diphenyltin(IV) di-4-nitrobenzoate and triphenyltin(IV) 4-nitrobenzoate of 87.27; 88.33, and 86.53%, respectively with optimum reflux time of 4 hours. The initial compounds and the compounds synthesized were characterized using IR and UV spectrophotometer to identify the functional group and λmax contained in the compound. Furthermore, microelemental analysis was also done using the microelemental analyzer to compounds synthesized. Based on the data from microanalysis, the compounds obtained were quite pure as the differences in data obtained compared to the theoretical calculations of in the range of 1-5%. The IC50 values obtained from preliminary anticancer activity against leukemia cells L-1210 for dibutyltin(IV) di-4-nitrobenzoate, diphenyltin(IV) di-4-nitrobenzoate and triphenyltin(IV) 4-nitrobenzoate were 18.8; 8.8, and 2.27 μg/mL, respectively.)

Tipe Karya Ilmiah: Skripsi
Subyek: Q Science (General) > Q Science (General)
Q Science (General) > QD Chemistry
Program Studi: Fakultas MIPA > Prodi Kimia
Depositing User: Farid Hambali Prihantoro, A.Md.
Date Deposited: 03 Feb 2014 07:09
Last Modified: 03 Feb 2014 07:09
URI: http://digilib.unila.ac.id/id/eprint/911

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