DEWI FAUZI, ISAURA (2025) UJI DAYA HAMBAT EKSTRAK DAUN PEPAYA (Carica papaya L.) TERHADAP PERTUMBUHAN BAKTERI Staphylococcus aureus DAN Escherichia coli. FAKULTAS KEDOKTERAN, UNIVERSITAS LAMPUNG.
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Abstrak (Berisi Bastraknya saja, Judul dan Nama Tidak Boleh di Masukan)
Background: Bacterial infections such as Staphylococcus aureus (S. aureus) and Escherichia coli (E. coli) are the main causes of infectious diseases that lead to increased morbidity and mortality. The utilization of natural materials such as papaya leaves (Carica papaya L.) which contain active compounds with the potential to be developed into antibiotics. Objective: To determine the inhibitory effect of papaya leaf extract (Carica papaya L.) and to understand the inhibitory effect of each concentration on the growth of S. aureus and E. coli bacteria. Methods: This study uses a true experimental post-test only control group design. The samples consisted of ethanol extracts of papaya leaves with concentrations of 20%, 40%, 60%, 80%, 100%, as well as a positive control (ciprofloxacin) and a negative control (aquadest). Antibacterial test was conducted using the well diffusion method against S. aureus and E. coli. Statistical analysis was performed using One Way ANOVA test and the Post Hoc LSD test. Results: The highest average at a 100% concentration against S. aureus was 16.68 mm and E. coli was 15.7 mm. Positive control (ciprofloxacin) measured 38.1 mm for S. aureus and 40.17 mm for E. coli, while the negative control (aqua dest) showed no inhibitory effect. The results of the One Way ANOVA test on S. aureus p = <0,001 and E. coli p = <0,001. The Post hoc LSD test for both bacteria showed significant differences between several treatment groups. Conclusion: There is an inhibitory effect of papaya leaf extract (Carica papaya L.) at concentrations of 20%, 40%, 60%, 80%, and 100% against the positive control in inhibiting the growth of S. aureus and E. coli. Keyword: Carica papaya L., Staphylococcus aureus, Escherichia coli, Antibacterial, Well Diffusion Latar Belakang: Infeksi bakteri seperti Staphylococcus aureus (S. aureus) dan Escherichia coli (E. coli) merupakan penyebab utama penyakit infeksi yang berdampak pada peningkatan morbiditas dan mortalitas. Pemanfaatan bahan alami seperti daun pepaya (Carica papaya L.) yang mengandung senyawa aktif dapat dikembangkan menjadi antibiotik. Tujuan Penelitian: Untuk mengetahui daya hambat ekstrak daun pepaya (Carica papaya L.) dan mengetahui daya hambat setiap konsentrasi terhadap pertumbuhan bakteri S. aureus dan E. coli. Metode Penelitian: Penelitian ini menggunakan rancangan true experimental post-test only control group. Sampel berupa ekstrak etanol daun pepaya (Carica papaya L.) dengan konsentrasi 20%, 40%, 60%, 80%, 100%, serta kontrol positif (ciprofloxacin) dan kontrol negatif (akuades). Uji antibakteri dilakukan dengan metode difusi sumuran terhadap S. aureus dan E. coli. Uji analisis statistik menggunakan uji One Way ANOVA serta uji Post Hoc LSD. Hasil Penelitian: Rerata tertinggi pada konsentrasi 100% terhadap S. aureus 16,68 mm dan E. coli 15,7 mm. Kontrol positif (ciprofloxacin) senilai 38,1 mm terhadap S. aureus, E. coli 40,17 mm, dan kontrol negatif (akuades) tidak menunjukkan daya hambat. Hasil uji One Way ANOVA pada S. aureus p = <0,001 dan E. coli p = <0,001. Uji Post hoc LSD kedua bakteri menunjukkan perbedaan signifikan antar beberapa kelompok perlakuan. Kesimpulan: Terdapat daya hambat ekstrak daun pepaya (Carica papaya L.) pada konsentrasi 20%, 40%, 60%, 80% dan 100% terhadap kontrol positif dalam menghambat pertumbuhan S. aureus dan E. coli. Kata Kunci: Carica papaya L., Staphylococcus aureus, Escherichia coli, Antibakteri, Difusi Sumuran
| Jenis Karya Akhir: | Skripsi |
|---|---|
| Subyek: | 600 Teknologi (ilmu terapan) 600 Teknologi (ilmu terapan) > 607 Pendidikan, riset, topik terkait 600 Teknologi (ilmu terapan) > 610 Ilmu kedokteran, ilmu pengobatan dan ilmu kesehatan |
| Program Studi: | FAKULTAS KEDOKTERAN (FK) > Prodi S1-Pendidikan Dokter |
| Pengguna Deposit: | 2506862289 Digilib |
| Date Deposited: | 17 Jun 2025 08:41 |
| Terakhir diubah: | 17 Jun 2025 08:41 |
| URI: | http://digilib.unila.ac.id/id/eprint/88909 |
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