SINTESIS DAN KARAKTERISASI SERTA UJI PENDAHULUAN AKTIVITAS ANTIKANKER BEBERAPA SENYAWA ORGANOTIMAH(IV) 3-NITROBENZOAT TERHADAP SEL LEUKEMIA L-1210 (SYNTHESIS, CHARACTERIZATION, AND IN VITRO ANTICANCER ACTIVITY OF SOME ORGANOTIN(IV) 3-NITROBENZOAT COMPOUNDS AGAINST LEUKEMIA CELL L-1210)

Sardimin, Siska Dwi Aryani (2013) SINTESIS DAN KARAKTERISASI SERTA UJI PENDAHULUAN AKTIVITAS ANTIKANKER BEBERAPA SENYAWA ORGANOTIMAH(IV) 3-NITROBENZOAT TERHADAP SEL LEUKEMIA L-1210 (SYNTHESIS, CHARACTERIZATION, AND IN VITRO ANTICANCER ACTIVITY OF SOME ORGANOTIN(IV) 3-NITROBENZOAT COMPOUNDS AGAINST LEUKEMIA CELL L-1210). Fakultas MIPA, Universitas Lampung.

[img]
Preview
FIle PDF
4. COVER DALAM.pdf - Published Version

Download (27Kb) | Preview
[img]
Preview
FIle PDF
3. ABSTRAK.pdf - Published Version

Download (8Kb) | Preview
[img]
Preview
FIle PDF
2. ABSTRACT.pdf - Published Version

Download (40Kb) | Preview
[img]
Preview
FIle PDF
5. HAL PERSETUJUAN.pdf - Published Version

Download (199Kb) | Preview
[img]
Preview
FIle PDF
6. HAL PENGESAHAN.pdf - Published Version

Download (190Kb) | Preview
[img]
Preview
FIle PDF
11. DAFTAR ISI.pdf - Published Version

Download (19Kb) | Preview
[img]
Preview
FIle PDF
BAB I.pdf - Published Version

Download (95Kb) | Preview
[img]
Preview
FIle PDF
BAB II.pdf - Published Version

Download (204Kb) | Preview
[img]
Preview
FIle PDF
BAB III.pdf - Published Version

Download (279Kb) | Preview
[img] FIle PDF
BAB IV.pdf - Published Version
Restricted to Hanya pengguna terdaftar

Download (838Kb)
[img]
Preview
FIle PDF
BAB V.pdf - Published Version

Download (96Kb) | Preview
[img]
Preview
FIle PDF
DAFTAR PUSTAKA.pdf - Published Version

Download (107Kb) | Preview
[img] Archive
LAMPIRAN.zip - Published Version

Download (947Kb)

Abstrak

Pada penelitian ini telah dilakukan sintesis senyawa dibutiltimah(IV) di-3-nitrobenzoat, difeniltimah(IV) di-3-nitrobenzoat, dan trifeniltimah(IV) 3-nitrobenzoat dengan berat padatan putih masing-masing senyawa 87,10%, 84,06%, dan 83,64%, pada waktu refluks optimum empat jam. Hasil karakterisasi spektrofotometer IR menunjukkan adanya serapan C=O untuk senyawa tersebut berturut-turut adalah pada 1591,89 cm-1, 1705,36 cm-1, dan 1597,94 cm-1 yang menandakan terdapatnya gugus karbonil yang berasal dari asam 3-nitrobenzoat. Senyawa hasil sintesis berupa senyawa dibutiltimah(IV) di-3-nitrobenzoat, difeniltimah(IV) di-3-nitrobenzoat, dan trifeniltimah(IV) 3-nitrobenzoat juga dikarakterisasi dengan spektrofotometer UV-Vis untuk melihat pergeseran panjang gelombangnya. Data mikroanalisis menggunakan microelemental analyzer menunjukkan bahwa senyawa hasil sintesis telah murni dengan perbedaan hasil mikroanalisis dengan perhitungan secara teori berkisar 1-5%. Pengujian antikanker menunjukkan nilai IC50 masing-masing senyawa hasil yaitu 20,59; 9,29; dan 3,06, yang menunjukkan bahwa senyawa trifeniltimah(IV) 3-nitrobenzoat memiliki keakftifan terhadap antikanker yang lebih tinggi. (In this research, the synthesis of dibutyltin(IV) di-3-nitrobenzoate, diphenyltin(IV) di-3-nitrobenzoate, and triphenyltin(IV) 3-nitrobenzoate were performed which produced the white solid of 87.10%, 84.06%, and 83.64%, respectively in the optimum reflux time of 4 hours. The result of IR spectrophotometer characterization showed that there were absorption of C=O for those compounds at 1591.89 cm-1, 1705.36 cm-1, and 1597.94 cm-1 which indicated that there was carbonil group from 3-nitrobenzoate acid. The compounds synthesized as dibutyltin(IV) di-3-nitrobenzoate, diphenyltin(IV) di-3-nitrobenzoate, and triphenyltin(IV) 3-nitrobenzoate were also characterizated using UV-Vis spectrophotometer in order to see the shift of their wavelength. The microanalysis data using microelemental analyzer showed that the compound synthesized were quite pure with the difference of microanalysis result and the theoretically calculation was in the range of 1-5%. In vitro activity test showed that the IC50 value of each compound synthesized were 20.59; 9.29; and 3.06, respectively, in which triphenyltin(IV) 3-nitrobenzoate showed the highest activity towards anti-cancer.)

Jenis Karya Akhir: Skripsi
Subyek: > Q Science (General)
> QD Chemistry
Program Studi: Fakultas MIPA > Prodi Kimia
Pengguna Deposit: UPT Perpustakaan Unila
Date Deposited: 08 Jan 2014 05:22
Terakhir diubah: 08 Jan 2014 05:22
URI: http://digilib.unila.ac.id/id/eprint/115

Actions (login required)

Lihat Karya Akhir Lihat Karya Akhir